Impacto del tiempo entre la extracción y el análisis de la gasometría arterial en la práctica clínica / The Effect Of Time Between Sample Extraction And Arterial Blood Gas Analysis In Clinical Practice

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Vulnerabilidades de pescadores de comunidades ribeirinhas às Infecções Sexualmente Transmissíveis / Vulnerabilidad de los pescadores de las comunidades costeras a las infecciones de transmisión sexual / Vulnerability of fishermen from coastal communities to sexually transmitted infections

RESUMO Introdução: as Infecções Sexualmente Transmissíveis, especificamente a Síndrome da Imunodeficiência Adquirida são patologias que representam grandes desafios para a saúde no contexto mundial, merecendo destaque devido ao seu alto potencial de disseminação. No universo masculino, verifica-se que vem se intensificando o aumento da incidência dessas patologias, sobretudo nos grupos representados pelos adolescentes e jovens. Objetivo: analisar as vulnerabilidades de pescadores de comunidades ribeirinhas às infecções sexualmente transmissíveis. Métodos: trata-se de uma pesquisa exploratória e descritiva de abordagem qualitativa, realizada nas comunidades ribeirinhas do interior piauiense, Brasil. A amostra foi composta por 18 homens que vivem nessas comunidades. Resultados: os resultados foram divididos em duas categorias, a saber: Vulnerabilidades de pescadores relacionadas as infecções sexualmente transmissíveis e práticas preventivas; Políticas públicas de saúde voltadas para a saúde sexual dos homens. Percebeu-se que há uma grande deficiência de conhecimento dos pescadores sobre essas infecções, devido ao baixo grau de escolaridade e a ausência de ações educativas em saúde por parte da Estratégia de Saúde da Família, o que os torna muito vulneráveis às Infecções Sexualmente Transmissíveis. Conclusão: há uma necessidade de realizar ações educativas em saúde para os pescadores, por parte da Estratégia Saúde da Família, visto que as políticas de saúde para os homens contemplam ações para as populações mais vulneráveis(AU)

RESUMEN Introducción: las infecciones de transmisión sexual son enfermedades que constituyen importantes desafíos para la salud en el contexto global, y el síndrome de inmunodeficiencia adquirida merece una mención especial debido a su alto potencial de propagación. En el universo masculino, parece que se está intensificando la creciente incidencia de estas enfermedades, especialmente en los grupos representados por adolescentes y jóvenes. Objetivo: analizar las vulnerabilidades de pescadores de comunidades ribereñas con las infecciones de transmisión sexual. Métodos: estudio con enfoque cualitativo, exploratorio y descriptivo, llevado a cabo en las comunidades ribereñas de Piauí interior. La muestra consistió en 18 hombres que viven en estas comunidades. Resultados: se dividieron en dos categorías, a saber: los pescadores de vulnerabilidad relacionados con las prácticas de prevención de infecciones y las políticas públicas de salud centrados en la salud sexual de los hombres de transmisión sexual. Se observó que existe deficiencia de los conocimientos de los pescadores sobre estas infecciones, debido al bajo nivel de educación y la falta de las acciones en salud en la Estrategia Salud de la Familia, que los hace muy vulnerables a las infecciones de transmisión sexual. Conclusión: se necesitan actividades de educación en la salud de los pescadores, mediante la estrategia de salud de la familia, como las políticas de salud para los hombres que incluyen acciones para las poblaciones más vulnerables(AU)

ABSTRACT Introduction: Sexually transmitted infections, specifically the acquired immunodeficiency syndrome are diseases that pose major challenges for health in the global context deserves special mention because of its high potential for spread. In the male universe, it appears that is intensifying the increasing incidence of these diseases, especially in the groups represented by adolescents and youth. Objective: Analyze the fishing vulnerabilities related to sexuality and sexually transmitted infections prevention practices. Methods: This is an exploratory and descriptive qualitative approach, carried out in the riverine communities of Piaui interior. The sample consisted of 18 men who live in these communities. Results: The results were divided into two categories, namely: Vulnerability fishermen related and prevention practices Sexually Transmitted Infections; health public policies focused on the sexual health of men. It was noticed that there is a big fishermen's knowledge deficiency on these infections, due to the low level of education and lack of educative health actions by the Family Health Strategy, which makes them very vulnerable to sexually transmitted infections. Conclusion: There is a need for educational activities in health for fishermen, by the Family Health Strategy, as health policies for men include actions for the most vulnerable populations(AU)

Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus.

BACKGROUND: To our knowledge there are no studies assessing anti-Ro/SSA and anti-La/SSB autoantibodies in a large population of childhood-systemic lupus erythematosus (cSLE) patients. METHODS: This was a retrospective multicenter cohort study performed in 10 Pediatric Rheumatology services, São Paulo state, Brazil. Anti-Ro/SSA and anti-La/SSB antibodies were measured by enzyme linked immunosorbent assay (ELISA) in 645 cSLE patients. RESULTS: Anti-Ro/SSA and anti-La/SSB antibodies were evidenced in 209/645 (32%) and 102/645 (16%) of cSLE patients, respectively. Analysis of cSLE patients with and without anti-Ro/SSA antibodies revealed higher frequencies of malar rash (79% vs. 71%, p=0.032), photosensitivity (73% vs. 65%, p=0.035), cutaneous vasculitis (43% vs. 35%, p=0.046) and musculoskeletal involvement (82% vs. 75%, p=0.046) in spite of long and comparable disease duration in both groups (4.25 vs. 4.58years, p=0.973). Secondary Sjögren syndrome was observed in only five patients with this antibody (2.5% vs. 0%, p=0.0035), two of them with concomitant anti-La/SSB. The presence of associated autoantibodies: anti-Sm (50% vs. 30%, p<0.0001), anti-RNP (39% vs. 21%, p<0.0001) and anti-ribossomal P protein (46% vs. 21%, p=0.002) was also significantly higher in patients with anti-Ro/SAA antibodies. Further evaluation of cSLE patients with the presence of anti-La/SSB antibodies compared to those without these autoantibodies showed that the frequency of alopecia (70% vs. 51%, p=0.0005), anti-Sm (59% vs. 31%, p<0.0001) and anti-RNP (42% vs. 23%, p<0.0001) were significantly higher in the former group. CONCLUSIONS: Our large multicenter cohort study provided novel evidence in cSLE that anti-Ro/SSA and/or anti-La/SSB antibodies were associated with mild manifestations, particularly cutaneous and musculoskeletal. Secondary Sjögren syndrome was rarely observed in these patients, in spite of comparable frequencies of anti-Ro/SSA and/or anti-La/SSB reported for adult SLE.

Safety and efficacy of wavefront-guided myopic laser in situ keratomileusis using a new wavefront sensor technology: first 100 cases.

PURPOSE: To evaluate the safety and efficacy of wavefront-guided laser in situ keratomileusis (LASIK) for the correction of low to high myopia and myopic astigmatism using data derived from a new-generation Hartmann-Shack aberrometer. SETTING: Refractive Surgery Unit, Bordeaux Hospital University, France. DESIGN: Retrospective case series. METHODS: This retrospective study analyzed the initial group of eyes treated with wavefront-guided LASIK for myopia and myopic astigmatism using the Visx S4IR excimer laser and wavefront data derived from a new Hartmann-Shack aberrometer (iDesign Advanced Wavescan aberrometer). Refractive (refraction and refractive accuracy) and visual outcomes (uncorrected [UDVA] and corrected [CDVA] distance visual acuities) were recorded 3 months postoperatively. RESULTS: The study included 100 eyes of 50 consecutively treated patients. The mean decimal UDVA improved from 0.1 ± 0.1 (SD) preoperatively to 1.1 ± 0.15 postoperatively (P < .01). A monocular UDVA of 20/16, 20/20, and 20/25 were achieved in 76.6%, 94.4%, and 96.6% of eyes, respectively. The postoperative manifest spherical equivalent was within ±0.5 diopter in all eyes. No eye lost 2 or more lines of CDVA, and 29.2% of the eyes gained 1 or more lines of CDVA. CONCLUSION: Wavefront-guided LASIK performed using data derived from the new Hartmann-Shack aberrometer was safe, effective, and predictable for treating myopia and myopic astigmatism. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus.

BACKGROUND: Data regarding the prevalence of chronic spontaneous urticaria (CSU) in childhood-onset systemic lupus erythematosus (cSLE) patients and possible associated factors are limited to a few case reports. The objectives of this study were to assess CSU in a large cSLE population, in order to evaluate the demographic data, clinical manifestations, disease activity/damage, laboratory abnormalities and treatment. METHODS: A retrospective multicenter cohort study (Brazilian cSLE group) was performed in 10 Pediatric Rheumatology services and included 852 cSLE patients. CSU was diagnosed according to the guidelines of the European Academy of Allergy and Clinical Immunology, the Global Allergy and Asthma European Network, the European Dermatology Forum and the World Allergy Organization. Patients with CSU (evaluated at urticaria diagnosis) and patients without CSU (evaluated at the last visit) were assessed for lupus clinical/laboratory features and treatment. RESULTS: CSU was observed in 10/852 cSLE patients (1.17%). The median of cSLE duration at urticaria diagnosis was 0 (-3 to 5) years. Comparison of cSLE patients with and without CSU revealed a greater frequency of constitutional symptoms (40 vs. 8%, p = 0.006), reticuloendothelial system involvement (30 vs. 3%, p = 0.003), mucocutaneous (90 vs. 28%, p < 0.0001) and musculoskeletal manifestations (50 vs. 6%, p < 0.0001) and methylprednisolone pulse therapy use (60 vs. 9%, p < 0.0001) in the former group. The frequency of immunosuppressive treatment was lower in patients with CSU (p = 0.018). The median SLE Disease Activity Index 2000 (12 vs. 2, p < 0.0001) and erythrocyte sedimentation rate (40 vs. 19 mm/1st hour, p = 0.024), was higher in patients with CSU. CONCLUSIONS: To our knowledge, this is the first study with evidence that CSU may be linked to cSLE. We also demonstrated that this particular skin manifestation occurs predominantly at disease onset and is associated with lupus moderate/high disease activity without major organ involvement.

Wavefront analysis after wavefront-guided myopic LASIK using a new generation aberrometer.

PURPOSE: To evaluate the short-term aberrometric outcomes of wavefront-guided LASIK for the correction of low to moderate myopia and myopic astigmatism using a new generation aberrometer (iDesign System; Abbott Medical Optics, Inc., Santa Ana, CA). METHODS: Charts of 92 eyes of 46 patients successively treated by wavefront-guided LASIK for myopia and/or myopic astigmatism were retrospectively reviewed at 3 months postoperatively. Aberrometric analysis of the wavefront errors was performed for a 6-mm pupil diameter to investigate the surgical induction of the total higher-order aberrations (HOAs), spherical aberrations Z41, and coma-like aberrations Z3 . Additionally, correlations between the magnitude of aberrations induced with the level of achieved correction and the preoperative amount of aberrations were tested. RESULTS: A minimal but statistically significant induction in all of the aberrations tested was observed at 3 months postoperatively (P < .01), with an increase (calculated for a 6-mm pupil) of +0.12 + 0.2, +0.06 + 0.1, and 0.05 + 0.1 pm in the root mean square (RMS) total HOA, RMS spherical aberration Z41, and RMS coma Z31, respectively. The postoperative change in aberrations was poorly correlated with both the level of achieved myopic correction for all of the aberrations tested (r < 0.3; P < .001) and the preoperative level of spherical aberrations (r = 0.3; P < .05) and coma (r = 0.46; P < .05). CONCLUSIONS: Wavefront-guided LASIK using the new generation Hartmann-Shack aberrometer allows a minimal induction of HOAs regardless of the level of myopic correction achieved or the preoperative magnitude of aberrations.

"Milk of calcium": a rare presentation of calcinosis.

Rheumatic diseases such as juvenile dermatomyositis (JDM), juvenile sistemic lupus erythematosus (JSLE) and sistemic sclerosis may have calcium deposits in the subcutaneous and muscle tissues known as calcinosis. Extensive calcium-laden fluid collections referred as "milk of calcium" are rare forms of calcinosis in JDM. We describe a 15-year old patient with overlap syndrome (sclerodermatomyositis and JSLE), whose magnetic resonance imaging (MRI) showed perimusculares fluid collections in the lower limbs. During surgery, we observed the presence of whitish fluid collection suggestive of "milk of calcium".

Sclerotic metaphyseal lines in children and adolescents treated with alendronate.

INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radiographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients (52.3%) had sclerotic lines in the metaphysis of long bones. The most frequent site was the tibia (8/11 patients), followed by the femur (7/11), humerus (6/11), radius (4/11), ulna (3/11), and fibula (2/11). Regression of radiographic changes during the study period (up to 1.1 years after discontinuation of alendronate) was not observed. CONCLUSION: If used carefully, alendronate is safe and radiographic changes have not been shown to be clinically relevant.

[Technical nursing course at PROFAE-Ceará: an analysis from the graduates' perspective]. / Curso Técnico de Enfermagem do PROFAE--Ceará: uma análise sob a óptica dos egressos.

This study aimed to analyze PROFAE's technical Nursing course from the perspective of the students that had completed the course regarding the identification of strengths and weaknesses they identified during the program. This exploratory, qualitative-based descriptive study was carried out with graduates of the Public Healthcare School of Ceará, who had completed the course. Two focal groups composed of 21 graduates were organized in the months of May and June 2007. The content analysis was used forthe comprehension of the discourses. Results indicated that the course provided the graduates with a great deal of knowledge, thus positively affecting their lives and transforming them into agents of change in their work contexts. The study analyzed the curriculum, the methodology, the textbooks and other available materials, as well as the professors. The reported weaknesses were training field limitations, the length of the course, and the sponsorship management. The present assessment represents an important tool for the development of the course, generating an opportunity for the improvement of the proposal.

Treatment of refractory juvenile idiopathic arthritis via pulse therapy using methylprednisolone and cyclophosphamide.

CONTEXT: Patients with refractory juvenile idiopathic arthritis can benefit from aggressive therapy. CASE REPORT: We followed the clinical course of 4 patients (2 male, 2 female) aged 9.1-17.8 years (mean of 14.5 years) with polyarticular onset of juvenile rheumatoid arthritis and one 16-year-old boy with juvenile spondyloarthropathy associated with inflammatory bowel disease. All the juvenile rheumatoid arthritis patients fulfilled the diagnostic criteria established by the American College of Rheumatology. All patients had unremitting arthritis despite maximum therapy. All patients began receiving treatment using intravenous cyclophosphamide at 500-750 mg/m and intravenous methylprednisolone at 30 mg/kg, for 3 days monthly (1 g maximum). The patients received between 3 and 11 monthly treatments, and/or 3-5 treatments every two months for 12 months, according to the severity of the disease and/or response to the therapy. All but one patient were evaluated retrospectively at the start (time 0) and 6 months (time 1), and 12 months (time 2) after the beginning of the treatment. A rapid and clinically significant suppression of systemic and articular manifestations was seen in all patients. Our results showed the favorable effect of this treatment on the clinical and some laboratory manifestations of juvenile idiopathic arthritis.