RESUMEN
Anti-2,4-dinitrophenyl (DNP) IgE producing hybridoma B 53 when injected subcutaneously is established equally well in syngeneic BALB/c (heavy-chain allotype a) and congenic CB20 (heavy-chain allotype b) mice. However, secretion of anti-DNP IgE monoclonal antibody is greatly suppressed in CB20 mice. B 53 cells taken from the subcutaneous tumors of CB20 mice produce anti-DNP IgE in vivo in BALB/c mice and in vitro. No difference was observed in IgE production between these cells and the controls taken from BALB/c mice. The suppression of IgE production was due to T cells and/or their product(s) of CB20 mice.
Asunto(s)
Hibridomas/metabolismo , Alotipos de Inmunoglobulinas/inmunología , Inmunoglobulina E/metabolismo , Linfocitos T/inmunología , Animales , Antígenos de Superficie/inmunología , Dinitrofenoles/inmunología , Tolerancia Inmunológica , Ratones , Ratones Endogámicos , Bazo/inmunología , Antígenos Thy-1RESUMEN
The inheritance of responsiveness to histamine-sensitizing factor of pertussis bacilli was examined in (SWR/J x CBA/J)F(1) x CBA/J backcross mice. We found that about half of the backcross mice inherited this responsiveness in both sexes. There was no linkage between the inheritance of responsiveness to histamine-sensitizing factor and the H-2(q) locus from the sensitive SW/J progenitor.