The origin of climate changes.

Investigation on climate change is coordinated by the Intergovernmental Panel on Climate Change (IPCC), which has the delicate task of collecting recent knowledge on climate change and the related impacts of the observed changes, and then developing a consensus statement from these findings. The IPCC's last review, published at the end of 2007, summarised major findings on the present climate situation. The observations show a clear increase in the temperature of the Earth's surface and the oceans, a reduction in the land snow cover, and melting of the sea ice and glaciers. Numerical modelling combined with statistical analysis has shown that this warming trend is very likely the signature of increasing emissions of greenhouse gases linked with human activities. Given the continuing social and economic development around the world, the IPCC emission scenarios forecast an increasing greenhouse effect, at least until 2050 according to the most optimistic models. The model ensemble predicts a rising temperature that will reach dangerous levels for the biosphere and ecosystems within this century. Hydrological systems and the potential significant impacts of these systems on the environment are also discussed. Facing this challenging future, societies must take measures to reduce emissions and work on adapting to an inexorably changing environment. Present knowledge is sufficientto start taking action, but a stronger foundation is needed to ensure that pertinent long-term choices are made that will meet the demands of an interactive and rapidly evolving world.

Allergic rhinitis due to house dust mites: evaluation of the efficacy of specific sublingual immunotherapy.

BACKGROUND: The efficacy and safety of sublingual immunotherapy (SLIT) in patients with chronic rhinitis related to sensitization to house dust mites are still controversial. METHODS: After application of an anti-mite mattress cover, patients were only included in the study when the cumulative symptom score over a fortnight was greater than 70 out of a possible total of 168. Thirty-two of the 120 patients selected were randomized to receive SLIT for 2 years: 17 received placebo and 15 received the Dermatophagoides pteronyssinus and D. farinae 50/50 allergen extract. RESULTS: Significant between-group differences were observed after 1 year and persisted at the end of the second year for the rhinitis total score (P < 0.02), blocked nose score (P < 0.01) and nasal itching score (P < 0.01). Skin reactivity to house dust mites was significantly reduced in the group receiving house dust mite extract (P < 0.03). No statistical difference was observed between the two groups for medication scores, but a low medication consumption was observed in all patients. No serious and no systemic adverse reactions were reported. CONCLUSION: This study indicates the superiority of active treatment vs. placebo, evaluated on efficacy criteria (rhinitis score) or objective criteria (skin reactivity). The availability of a solid form (tablet) could represent a progress in terms of patient acceptability.

Pulmonary sequestration treated by video-assisted thoracoscopic resection.

An undiagnosed pulmonary sequestration showed abnormal vessels at video-assisted thoracoscopy. Mediastinal or lung masses which are situated at the base of the thorax must be dissected with great caution because of the possible existence of vascular malformations.