RESUMEN
In this paper, nano-hybrid particles of Ag@Fe2O3 based on O-carboxymethylchitosan were successfully synthesized using different reducing agents (NaBH4, sucrose) and without reducing agent. The smallest silver nanoparticles were those prepared without reducing agent (â¼5±3nm). The average size of silver particles prepared with NaBH4 is around 5-15nm, and for samples prepared with sucrose, the average particle size is 10-25nm. The magnetization curves are roughly reversible, indicating that γ-Fe2O3 nanoparticles transit to a superparamagnetic state. Nanocomposites subjected to antimicrobial tests showed great antimicrobial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria, and good activity against the yeast Candida albicans and resistant strains of Staphylococcus aureus. The antibacterial behavior as a function of time was investigated in microbial growth kinetics, and the best nanocomposite was the one without reducing agent, which completely inhibited microbial growth for 48h.
Asunto(s)
Antiinfecciosos/síntesis química , Quitosano/análogos & derivados , Nanopartículas del Metal/química , Antiinfecciosos/química , Antiinfecciosos/farmacología , Candida albicans/efectos de los fármacos , Candida albicans/crecimiento & desarrollo , Quitosano/síntesis química , Quitosano/química , Quitosano/farmacología , Escherichia coli/efectos de los fármacos , Escherichia coli/crecimiento & desarrollo , Compuestos Férricos/síntesis química , Compuestos Férricos/química , Compuestos Férricos/farmacología , Pruebas de Sensibilidad Microbiana , Nanocompuestos/química , Staphylococcus aureus/efectos de los fármacos , Staphylococcus aureus/crecimiento & desarrolloRESUMEN
This paper studied the synthesis, characterization and use of the magnetic chitosan nanogel for carrying meleimidic compounds. The hydrogel polymer was prepared using O-carboxymethylchitosan, which was crosslinked with epichlorohydrin for subsequent incorporation of iron oxide magnetic nanoparticles. The characterization revealed that the magnetic material comprises about 10% of the hydrogel. This material is comprised of magnetite and maghemite and exhibits ferro-ferrimagnetic behavior. The average particle size is 4.2 nm. There was high incorporation efficiency of maleimides in the magnetic nanogel. The release was of sustained character and there was a greater release when an external magnetic field was applied. The mathematical model that best explained the process of drug release by the magnetic hydrogel was that of Peppas-Sahlin. The magnetic nanogel proved to be an excellent candidate for use in drug-delivery systems.