RESUMEN
In vitro researches documented that reproterol, as well as salbutamol, is a powerful stimulant of adenyl cyclase activity in the trachea and bronchi but less potent than isoprenaline. The stimulation was antagonized by beta-blockers.
Asunto(s)
Adenilil Ciclasas/metabolismo , Encéfalo/enzimología , Bronquios/enzimología , Broncodilatadores/farmacología , Metaproterenol/análogos & derivados , Miocardio/enzimología , Teofilina/análogos & derivados , Tráquea/enzimología , Adenilil Ciclasas/análisis , Antagonistas Adrenérgicos beta/farmacología , Animales , Broncodilatadores/antagonistas & inhibidores , Pollos , Combinación de Medicamentos , Activación Enzimática , Hipotálamo/enzimología , Técnicas In Vitro , Metaproterenol/antagonistas & inhibidores , Metaproterenol/farmacología , Teofilina/antagonistas & inhibidores , Teofilina/farmacologíaAsunto(s)
6-Cetoprostaglandina F1 alfa/farmacología , Carboprost/farmacología , Epoprostenol/farmacología , Agregación Plaquetaria/efectos de los fármacos , Prostaglandinas F Sintéticas/farmacología , Prostaglandinas F/farmacología , Prostaglandinas/farmacología , Adenosina Difosfato/farmacología , Animales , Conejos , Trombina/farmacologíaRESUMEN
The intracarotidal injection of some bet-adrenergic blocking agents (dl-acebutolol, dl-, l-, d-alprenolol, dl-bunitrolol, dl-buthoxamine, dl-, l-, d-INPEA, dl-Ko 592, dl-metoprolol, dl-oxprenolol, dl-propranolol, dl-tolamolol) in anesthetized and bivagotomized dogs reduced the arterial blood pressure and the baro- and chemoreceptor activity. These effects seem to be mediated by an interaction with central nervous, cardiovascular and respiratory structures dependent on the carotid arteries and by a direct interference of these drugs with the carotid sinus baro- and chemoreceptor structures. Moreover, these effects were not a result of the beta-adrenolytic properties of the drugs.
Asunto(s)
Antagonistas Adrenérgicos beta/farmacología , Seno Carotídeo/efectos de los fármacos , Células Quimiorreceptoras/efectos de los fármacos , Presorreceptores/efectos de los fármacos , Antagonistas Adrenérgicos beta/administración & dosificación , Animales , Presión Sanguínea/efectos de los fármacos , Arterias Carótidas , Desnervación , Perros , Femenino , Inyecciones Intraarteriales , Masculino , Respiración/efectos de los fármacosRESUMEN
In the rat, narcotic doses of Althesin injected intraperitoneally did not modify blood glucose concentration nor plasma insulin concentration. On the contrary, a reduction of blood glucose concentration, associated with an increase of plasma insulin concentration was observed when narcotic doses of thiopental and ketamine were administered. Plasma renin concentrations decreased after injection of Althesin and thiopental but increased after injection of ketamine.
