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Ann Oncol ; 8 Suppl 1: 37-42, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9187427

RESUMEN

BACKGROUND: Anaplastic lymphoma kinase (ALK) is a tyrosine kinase inappropriately expressed in lymphoid tissue involved by CD30+ anaplastic large-cell lymphoma (ALCL) with the translocation t(2;5)(p23;q35)(, which juxtaposes the nucleophosmin gene (NPM) with that encoding ALK, resulting in a hybrid (NPM-ALK) message. PATIENTS AND METHODS: A polyclonal antibody against residues of the kinase portion of NPM-ALK (designated anti-ALK 11) was tested for clinical utility in paraffin sections of 44 cases of pediatric large-cell lymphoma (LCL) and 17 additional lymphoma cases, by streptavidin-biotin-alkaline phosphatase method. RESULTS: Nineteen of 20 CD30+ cases (the majority exhibiting anaplastic morphology) labeled with anti-ALK 11, and 5/28 CD30- cases were also ALK+ (3 T cells, 1 null cell, and 1 B cell). Sixteen of 17 B-cell pediatric LCLs were negative, as were 6/6 cases of Hodgkin's disease and 7/7 cases of adult B-cell lymphoma. In pediatric LCLs with adequate follow-up (24/44 ALK+), there was no significant association between ALK expression and two-year event-free survival, similar to the finding reported previously for CD30 expression in these cases. CONCLUSION: We conclude that the majority of pediatric CD30+ ALCLs show ALK overexpression, consistent with the presence of the t(2;5)-encoded NPM-ALK fusion, but that the clinical significance of this entity remains unproven.


Asunto(s)
Anticuerpos , Linfoma de Células B Grandes Difuso/enzimología , Proteínas de Neoplasias/análisis , Proteínas Tirosina Quinasas/análisis , Adulto , Quinasa de Linfoma Anaplásico , Niño , Humanos , Antígeno Ki-1/análisis , Linfoma de Células B Grandes Difuso/patología , Proteínas de Neoplasias/inmunología , Adhesión en Parafina , Proteínas Tirosina Quinasas/inmunología , Proteínas Tirosina Quinasas Receptoras
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