Differentiating Stages of Bipolar and Unipolar Depression-The Possible Role of sICAM-1 and sVCAM-1.

Increased immune-inflammatory activation has been repeatedly linked to etiopathogenesis and the progression of both major depressive disorder (MDD) and bipolar depression (BD). We explore the role of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in diagnostic differentiation and disorder progression in patients with MDD and BD. Serum levels of sICAM-1 and sVCAM-1 were measured in 137 patients (MDD = 93 and BD = 44) and compared with 73 healthy controls. The severity of psychopathology was assessed using the Hamilton Depression Rating Scale and Clinical Global Impression Scale. After adjustment for multiple confounders, we noticed significant downregulation of sVCAM-1 and upregulation of sICAM-1 levels in both patient groups. Decreased sVCAM-1 levels were detected in patients with acute episodes of BD when compared to MDD. Immune mediators were related to indicators of progression in both mood disorders. They also followed different post-treatment normalization patterns in MDD and BD and in relation to the stage of each disorder. Adhesion molecules could potentially be useful in discriminating between patients with MDD and BD and determining the possible progression of the disorders. Future nosological methods should include time-dependent pathoplasticity and biological correlates, at least for affective disorders.

Hopelessness and Fighting Spirit Relation with Illness Perception in Breast Cancer Patients / Relación de la Desesperanza y el Espíritu de Lucha con la Percepción de Enfermedad en Pacientes con Cáncer de Mama

Objective: Breast cancer is related to numerous psychological challenges, so the way of coping with the illness and its consequences may influence the outcome of treatment. Also, while confronting the diagnosis individuals will use their own illness perception in order to evaluate the possibility of healing and that can affect different areas of their functioning. The aim was to examine the degree to which women with breast cancer perceived their illness as threatening, as well as to examine potential predictive power of illness perception on strategies of coping with illness (hopelessness and fighting spirit). Method: 102 patients (Mage = 58.64, SDage = 10.143), who were hospitalized at the Center for Oncology and Radiology, for treatment of previously diagnosed breast cancer (Mmonths= 19.07, SDmonths = 23.49), were included in the study. The instruments included sociodemographic questionnaire, medical records, Brief Illness Perception Questionnaire and the Mini-Mental Adjustment to Cancer scale. Results: Patients declared to use fighting spirit more than hopeless style of coping the illness. Model that included Illness perception, Metastasis and Treatment length predicted 16% of Fighting Spirit variance. Model that included Illness perception and Age predicted 39% of Hopelessness variance. Conclusion: Illness perception can predict the tendency to resort to hopelessness and there is a correlation between certain sociodemographic and clinical characteristics with hopelessness and fighting spirit coping styles (AU)

Objetivo: El cáncer de mama se asocia a una serie de cambios psicológicos, el modo de afrontamiento la enfermedad y sus consecuencias puede influir en el resultado del tratamiento. Además, al afrontar el diagnóstico las personas utilizarán su propia percepción de la enfermedad para evaluar la posibilidad de curación, lo que puede afectar diferentes aspectos de su funcionamiento. El objetivo del presente estudio es examinar el nivel en el que las mujeres con cáncer de mama perciben su enfermedad como amenaza, además de examinar el posible valor predictivo de la percepción de la enfermedad en las estrategias del afrontamiento con la enfermedad (desesperanza y espíritu de lucha). Método:102 pacientes (Medad = 58,64; SDedad= 10,143) incluídos en la investigación, todos internados en el Centros de Oncología y Radioradio, para tratamiento (Mmonths = 19,07, SDmonths = 23,49) del cáncer mamario previamente diagnosticado. Los instrumentos incluyeron un cuestionario sociográfico, registros médicos, El Cuestionario Breve de Percepción de la Enfermedad y La Escala-Mini de Ajuste Mental al Cáncer. Resultados: Las pacientes afirmaron que utilizan más el espíritu combativo que la desesperación para afrontar la enfermedad. El modelo que incluía la percepción de la enfermedad, metástasis y duración del tratamiento pronosticó 16% de la divergencia del Espíritu Combativo. El modelo que incluía la percepción de la enfermedad y la edad pronosticó 39% de la divergencia de la desesperación. Conclusión:La percepción de la enfermedad puede pronosticar la tendencia hacia la desesperación; además, existe la relación entre ciertas características sociodemográficas y clínicas y ciertos mecanismos de afrontar la enfermedad, como son la desesperación o el espíritu combativo (AU)