[Atrophy of the granular layer of the cerebellar cortex in patients with nonlymphoblastic leukemia treated with cytosine arabinoside]. / Zanik warstwy ziarnistej kory mózdzku u chorych na bialaczki nielimfoblastyczne, leczonych arabinozydem cytozyny.

The reported analysis comprised 81 patients dying of acute non-lymphoblastic leukaemia type M1, M2, M4 and blastic crises in chronic myelocytic leukaemia. It was observed that the number of cases of cerebellar granular layer atrophy rose markedly in the years 1984-1990 as compared with 1976-1983 (45.4% vs 16.2%). It is suggested that this was due to the introduction of cytostatic treatment schedules with higher doses of cytosine arabinoside (ARAC), especially TAD (6-thioguanine, ARAC, daunorubicin). Cerebellar granular layer atrophy seems to be dependent rather on the cumulative dose of ARAC and not on a single high dose of that drug.

[Subacute leukoencephalopathy after radio- and chemotherapy of lymphoblastic lymphoma]. / Podostra leukoencefalopatia po radio-i chemioterapii chloniaka limfoblastycznego.

In a patient aged 34 with lymphoblastic lymphoma lymphomatous infiltrations developed in the leptomeninges but were controlled with radiotherapy and chemotherapy. Recurrence of neurological signs after 7 months was recognized as relapse of lymphoma in the central nervous system, but in the brain extensive demyelination and necrotic changes were found. The authors relate the development of leucoencephalopathy to the hypersensitivity of the nervous tissue to chemotherapy after previous radiotherapy.

[Risk factors of leukemic infiltration in patients with acute myeloblastic leukemia]. / Czynniki ryzyka wystepowania nacieków bialaczkowych w mózgowiu u chorych na ostre bialaczki mieloblastyczne.

On the basis of clinical neuropathological evaluation of 48 patients with acute myeloblastic leukaemias the authors analyse the risk factors of leukemic infiltrations developing in the brain. The investigations revealed that the distinct dissemination of leukemic cells in blood is the most important risk factor of such infiltrations. The risk increases significantly in older patients. Survival time and maintenance of high leukocytosis do not intensify the risk of leukemic infiltrations in the brain.

[Neurologic complications in high-grade non-Hodgkin's lymphomas. Clinico-neuropathological correlations]. / Powiklania neurologiczne w chloniakach nieziarniczych o wysokiej zlosliwosci. Korelacje kliniczno-neuropatologiczne.

The neurological and electroneurographic assessment was carried out in 56 patients with high-grade non-Hodgkin lymphomas. In 37 patients the neuropathological examination was also done. Polyneuropathy was the most frequent sign of nervous system involvement, observed in 40% of patients before chemotherapy and markedly enhanced by cytostatics. The signs of the central nervous system involvement were usually caused by lymphomatous infiltrations within leptomeninges, especially in lymphoblastic and immunoblastic lymphomas. The authors stress that cerebro-spinal fluid should be investigated several times for avoiding of false negative results. Signs of lymphomatous infiltrations disappeared after treatment, while signs of polyneuropathy due to chemotherapy increased during cytostatic treatment.

Impairment of peripheral nervous system in patients with non-Hodgkin's lymphomas treated with CBVPM/AVBP and CHOP schedules.

Clinical examination and conduction velocity measurements in peripheral nerves have been done on 56 patients with non-Hodgkin's lymphomas of high malignancy (NHL). It is suggested that: the evaluation of the influence of chemotherapy on peripheral nervous system (PNS) is possible by means of systematic neurological and electroneurographic studies; electroneurographic assessment is most important in the diagnosis of early subclinical stages of peripheral neuropathy; toxic influence of CBVPM/AVBP protocol on PNS is greater than CHOP schedule; impairment of PNS due to chemotherapy is reversible in patients during complete remission (CR).

Impairment of vertebral canal nervous structures after intrathecal prophylaxis in non-Hodgkin's lymphomas.

Neuropathological analysis of spinal cord and spinal roots as well as spinal leptomeninges after intrathecal methotrexate (MTX) therapy was performed in 44 cases of non-Hodgkin's lymphomas of high malignancy. It was showed that MTX applied according to the program applied as a prophylaxis against lymphomatous infiltrations in the central nervous system, caused demyelination of spinal roots and fibrosis of leptomeninges and their blood vessels. However, it does not affect spinal cord structures. Described morphological changes remained clinically mute, therefore they do not seem counterindicate prophylactic intrathecal MTX application.

[Rehabilitation of patients with myeloma and marked locomotor disfunction]. / Rehabilitacja lecznicza chorych na szpiczaka plazmatycznokomórkowego ze znaczna dysfunkcja narzadu ruchu.

Rehabilitation course in two patients with myeloma and marked locomotive system dysfunction is presented. Combination of pharmacotherapy and physical exercise enabled patients' to return to self-dependence and work.

[A case of pulmonary ossification]. / Przypadek kostnienia plucnego.

A case of pulmonary osteogenesis in a 82 year old male is presented. The patient was treated for generalized atherosclerosis, chronic bronchitis, emphysema and obscure gastrointestinal bleeding. Osteogenesis was diagnosed during autopsy. The multiple lesions were not demonstrable by radiological methods. Microscopical examination showed in the osteogenetic lesions bone marrow formation.

[Myeloblastoma of the brain and spinal cord in a patient with acute myelomonocytic leukemia]. / Myeloblastoma mózgu i rdzenia kregowego u chorego na ostra bialaczke mielomonocytowa.

A case of the myeloblastoma involving brain and spinal cord in a patient with acute myelomonocytic leukemia is reported. Numerous mitoses within the tumor provide an evidence for local cell proliferation in the neoplasm. Surgery combined with radiotherapy is suggested as the most efficient modality of the treatment.

[Degenerative changes within the nervous system in non-hodgkin's lymphoma]. / Zmiany zwyrodnieniowe w ukladzie nerwowym w chloniakach zlosliwych nieziarniczych.

The purpose of the paper was an attempt to become better acquainted with the character and incidence rate of degenerative changes within the nervous system in non-Hodgkin's lymphomas. Neuropathological studies were carried out in 30 patients, aged 17-75 years, deceased due to: lymphoblastic lymphoma (15 cases), centrocytic (5 cases), immunoblastic (4 cases), centroblastic (3 cases) and immunocytic lymphoma (3 cases). The investigations revealed that degenerative changes prevail in the peripheral nervous system: within the spinal roots in the form of primary demyelination and within peripheral nerves of axonal degeneration.