RESUMEN
None.
Asunto(s)
Transportadoras de Casetes de Unión a ATP , Neoplasias Colorrectales , Humanos , Transportadoras de Casetes de Unión a ATP/efectos de los fármacos , Transportadoras de Casetes de Unión a ATP/metabolismo , Neoplasias Colorrectales/tratamiento farmacológico , Terapia Molecular DirigidaRESUMEN
BACKGROUND: This current systematic review aimed to evaluate the role of surgical management and risk factors by pooled cases from all identified patients with colonic leiomyosarcomas. METHODS: The authors searched the Ovid MEDLINE, Embase, PubMed, and Cochrane databases using the keywords "colonic," "colon," and "leiomyosarcoma." Risk factors of colonic leiomyosarcoma in the pooled cohort were also evaluated. RESULTS: Between 1923 and 2019, 41 cases of colonic leiomyosarcoma were identified in 22 (53.7%) males and 19 (46.3%) females, with a mean and median age of 58.7 ± 2.2 years and 56.0 years. According to univariate analysis, smaller tumor size < 8 cm was significantly associated with longer progression-free survival (HR = 6.957, 95% CI 1.405-34.442; p = 0.017), and younger age < 60 years was trending toward better overall survival (HR = 2.765, 95% CI 0.924-8.272; p = 0.069). CONCLUSIONS: Colonic leiomyosarcomas are rare neoplasms with aggressive clinical behaviors. Age < 60 years and tumor size < 8 cm were favorable factors for patients' better survival.
Asunto(s)
Neoplasias del Colon/cirugía , Leiomiosarcoma/cirugía , Colon/patología , Colon/cirugía , Neoplasias del Colon/mortalidad , Neoplasias del Colon/patología , Humanos , Leiomiosarcoma/mortalidad , Leiomiosarcoma/patología , Pronóstico , Supervivencia sin Progresión , Factores de Riesgo , Tasa de Supervivencia , Resultado del TratamientoRESUMEN
A laboratory simulation test was conducted to study the microbial remediation of soils contaminated by medium and low concentration polycyclic aromatic hydrocarbons (PAHs), and the relationships between the degradation of PAHs and the inoculated and indigenous microbes. The addition of high-effective PAHs-degrading bacteria promoted the biodegradation of soil PAHs, and the effect was remarkable in the first two weeks. The biodegradation of test PAHs was phenanthrene < anthracene < pyrene < benzo [a] pyrene < chrysene, and negatively correlated with the diversity/abundance of soil bacterial population. In the same treatments, soil bacterial population structure varied less with time, and hence, to increase the activity of indigenous microbes would be an effective way to remediate the farmland soils contaminated by medium and low concentration PAHs.
Asunto(s)
Bacterias/clasificación , Biodiversidad , Hidrocarburos Policíclicos Aromáticos/metabolismo , Microbiología del Suelo , Contaminantes del Suelo/metabolismo , Biodegradación AmbientalRESUMEN
Tributyltin (TBT) compound is one of the main components of antifouling paint for boats and ships. The interaction of TBT compound and bovine serum albumin (BSA) was investigated by ultraviolet, fluorescence and circular dichroism (CD) spectra. The influences of concentration, acidity and organic solvent were also studied. The results showed that the interaction of TBT and BSA was dual, showing not only the hydrophobic actions of butyl groups but also the coordination action of tin cation with BSA molecule, which resulted in the exposures of aromatic amino acids residues of tryptophane and tyrosine in BSA molecule, the destruction of BSA secondary structure, the decrease in alpha-helix content, and the transformation of the conformation.
