[The protease inhibitor treatment of the disseminated intravascular coagulation syndrome in patients with liver cirrhosis]. / Lechenie s proteazni inkhibitori na sindroma na diseminirana intravazalna koagulatsiia pri bolni s chernodrobna tsiroza.

The results of the treatment of the syndrome of disseminated intravascular coagulopathy (DIC) in 41 patients with liver cirrhosis are reported. A relation between the severity of the liver impairment and the degree of the increase of the fibrin split products (FSP) was established. FSP above 100 micrograms/ml were found in patients with III class liver failure according to Child-Turcotte-Pugh and rating above 6.5 according to Z. Krustev. The administration of 30,000-60,000 U of the protease inhibitor contrykal led to mastering of the hemorrhagic diathesis in 19 of 21 patients (group A). The increased FSP in the serum fell (chi 2 = 5.79; p less than 0.001). In contrast, the administration of PAMBA and styptanon did not affect the hemorrhagic diathesis and DIC syndrome in 16 of 20 other patients (group B--chi 3 = 20.54; p less than 0.001). The authors recommend protease inhibitors as the treatment of choice of DIC syndrome in liver cirrhosis. Only in case of lack of effect should heparin be added.

[Automatic and manual methods for counting the thrombocytes in the blood]. / Avtomatichen i manualen metod za izbroiavane na trombotsitite v kruvta.

The results are compared from the platelet count in blood via chamber method with phase contrast and via electronic method with "Thrombocounter C". The reproducibility was studied in a series in the low, referent and high region. The electronic-automatic method gives a better reproducibility than the chamber method in all three regions. The poorest is the reproducibility in the low region where VC of both methods were the closest. The results from the two methods are in a high positive correlation (r = 0.9145, n = 61), the arithmetical mean from the electronic method being insignificantly higher than the mean of the chamber method, p greater than 0.05. In the low region, with platelets under 80 X 10(9)/l, the reliability of the electronic-automatic method is decreased. The results from the chamber and electronic-automatic method have a normal distribution. The electronic-automatic method is several times faster and less tiresome than the chamber one.

[Comparative studies of the analytical reliability of the results of various hematologic tests]. / Sravnitelni prouchvaniia vurkhu analitichnata nadezhnost na rezultatite ot niakoi khematologichni izsledvaniia.

In connection with the implementation of new methods and apparatuses for the determination of hemoglobin, hematocrit, erythrocytes, MCV, MCH, MCHC and leukocytes, the reproducibility was studied in series, compared with the arithmetical means and standard deviations and correlation analysis of the results was performed. Manual and automated, to various degrees, investigation methods were used. The reproducibility in hemoglobin determination was very good, with no significant differences between the means of the different methodical variants. The microhematocrit method provided a very good reproducibility for hematocrit, with significant differences in the means of the three methods used. The reproducibility of erythrocytes was between 1,09% and 2,34%. VK of leukocytes ranged from 2,0% to 5,73%. The differences between the means of the different methods for erythrocyte count and, in the majority of the cases, for leukocytes, allow the statistically significant comparability of the results. The best reproducibility from the mathematical indices of erythrocytes was obtained for MCHC. The correlation analysis showed a positive correlation between the methods compared in all parameters studied.