The electrocardiogram in ST elevation acute myocardial infarction: correlation with coronary anatomy and prognosis.

The electrocardiogram is considered an essential part of the diagnosis and initial evaluation of patients with chest pain. This review summarises the information that can be obtained from the admission electrocardiogram in patients with ST elevation acute myocardial infarction, with emphasis on: (1) prediction of infarct size, (2) estimation of prognosis, and (3) the correlations between various electrocardiographic patterns and the localisation of the infarct and the underlying coronary anatomy.

Frequency, characteristics, and clinical significance of transient ST segment elevation in patients with acute coronary syndromes.

BACKGROUND: Prior investigations of transient myocardial ischaemia have focused on ST depression events. Therefore, the purpose of this analysis was to determine the frequency, characteristics, and clinical significance of transient ST segment elevation in patients with acute coronary syndromes. METHODS: A secondary analysis from two prospective studies utilizing 12-lead ST segment monitoring was used to compare ST elevation vs ST depression events. RESULTS: Of 868 patients, 177 (20%) had 574 events (242, ST elevation; 332, ST depression). Patients with ST elevation were more likely to have single vessel coronary artery disease, whereas patients with ST depression were more likely to have triple vessel coronary artery disease. ST elevation events were of shorter duration, more often associated with chest pain, and had greater ST changes than ST depression events. There was no difference in clinical outcome between patients with ST elevation vs depression; however, those with ST events were more likely to have adverse hospital outcomes (OR, 3.67) or death (OR, 2.03) than patients without ST events. After controlling for clinical prognostic factors, transient ST events observed with continuous ST monitoring predicted hospital death independently from signs of ischaemia on the initial standard 12-lead ECG. CONCLUSIONS: Transient ST elevation is nearly as prevalent as transient ST depression in patients with acute coronary syndromes. Since the vast majority of ST events are brief and otherwise clinically silent, ST segment monitoring is more efficacious in detecting ischaemic events and in predicting adverse clinical outcomes than patients' symptoms or the initial standard 12-lead ECG.

Clinical consequences of ST-segment changes caused by body position mimicking transient myocardial ischemia: hazards of ST-segment monitoring?

A case is described in which an acute ST-segment change, presumably due to a change in body position, is erroneously interpreted as an acute ischemic event. Positional ST-segment changes during continuous, multi-lead electrocardiographic (ECG) monitoring are particularly challenging to distinguish from transient myocardial ischemia because 1) positional ECG templates are often not feasible to record at the beginning of monitoring in unstable patients; 2) positional ECG templates, if recorded, are often not readily accessible to clinicians for later comparison; 3) body position cannot be correlated with ST events because patients are out of the direct view of nurses during the event or clinicians review ST trends at a later time; 4) ST monitors typically do not store ECGs frequently enough to be able to observe on the ST trend the gradual ("ramp-like") onset of ST changes that is characteristic of transient ischemia; and 5) absence of chest pain with a ST event does not help clinicians identify false alarms because it is well understood that the majority of ischemic events are clinically silent.

New electrocardiographic criteria for posterior wall acute myocardial ischemia validated by a percutaneous transluminal coronary angioplasty model of acute myocardial infarction.

The standard 12-lead electrocardiogram (ECG) fails to detect ST-segment elevation in patients with posterior wall acute myocardial ischemia. However, additional posterior leads V(7-9) provide limited additional diagnostic information to the standard 12-lead ECG when an ischemic criterion of 1-mm ST elevation is used. No study is available to delineate the ischemic criteria in the posterior electrocardiographic leads. Continuous 15-lead ECGs (standard 12 lead + V(7-9)) were recorded in 53 subjects undergoing elective left circumflex coronary angioplasty (posterior ischemia model). ST amplitudes (J + 60 ms) at preangioplasty baseline were subtracted from maximal ST amplitudes during balloon occlusion to create a positive or negative change score (DeltaST) for each of the 15 leads. During 53 left circumflex occlusions, 26 subjects (49%) had DeltaST elevation of > or = 1 mm and 24 subjects (45%) had DeltaST elevation ranging from 0.5 to 0.95 mm in > or = 1 posterior leads. Five subjects (9%) had DeltaST elevation of > or = 1 mm in the posterior leads without DeltaST elevation anywhere in any of the 12 leads. The sensitivity in detecting myocardial ischemia using 15-lead ECGs (58%) was not statistically different from the standard 12-lead ECG (49%) (p = 0.06). Adjusting the ischemic criterion from 1 to 0.5 mm in V(7-9) significantly improved the sensitivity from 49% in the 12-lead ECG to 94% in the 15-lead ECG (p = 0.000). In addition, 12 subjects (23%) had posterior ST-segment elevation without anterior ST-segment depression. Thus, posterior leads V(7-9) contribute significant additional diagnostic information above and beyond the standard 12-lead ECG only when a new ischemic criterion of 0.5 mm instead of 1 mm ST elevation is applied to the posterior leads.

Prehospital delay time in acute myocardial infarction: an exploratory study on relation to hospital outcomes and cost.

BACKGROUND: Short prehospital delay is associated with improved outcomes in myocardial infarction, but the impact on cost has not been tested. Shortening delay time could reduce health care expenditures. METHODS AND RESULTS: Two hundred ninety-eight patients were examined with the use of a historic prospective design at 2 hospital sites. A secondary analysis was performed that used patients with confirmed myocardial infarction from the National Register of Myocardial Infarction and direct and indirect costs from the accounting system at the hospitals. Chi-square, Mann Whitney U, and Fisher exact tests were used for comparisons. Delay and 4 sets of variables were regressed on cost with the significant predictors used to construct a final model. The mean age was 71 +/- 14 years old; 62% were men. There were no major differences in demographics, cardiac history, risk factors, and admission characteristics between short and long delayers. Resource utilization and clinical outcomes were similar between the 2 groups; there was no difference in cost. Additional diagnostic procedures (odds ratio 2.92; 95% confidence interval 1.65-5.15) and complications (odds ratio 3.43; 95% confidence interval 2.03-5.82) were significant predictors of cost. Delay was not a predictor of high cost. CONCLUSIONS: Short prehospital delay was not associated with improved clinical outcomes, nor did it predict cost. Explanations include (1) the low utilization of early reperfusion therapy in the short delay group, (2) the study lacked sufficient power to detect a difference in cost between short and long delayers, and (3) the severity of illness could not be adequately measured. This issue warrants further study because of the potential impacts on health care expenditures.

Thoracic location of the lead with maximal ST-segment deviation during posterior and right ventricular ischemia: comparison of 18-lead ECG with 192 estimated body surface leads.

By using our database of continuous 18-lead electrocardiographic (ECG) recordings (standard + V3-5R + V7-9) during coronary angioplasty, we selected 68 patients with left circumflex balloon occlusions (posterior ischemia model) or proximal right coronary artery balloon occlusions (right ventricular IRV] ischemia model). ST-segment amplitudes (J + 60 ms) at preangioplasty baseline were subtracted from maximal ST amplitudes during balloon inflation to create a positive or negative change score (deltaST) for each of the 18 leads. DeltaST elevation was used to describe a change in the ST level in the positive direction from baseline, whether or not actual ST elevation from the isoelectric line was present. DeltaST depression was used to describe a change in the ST level in the negative direction from baseline, whether or not actual ST depression from the isoelectric line was present. ST amplitudes from 8 of the 12 standard leads were then used to estimate ST amplitudes at 192 body surface sites spanning the entire anterior and posterior thorax using the transformation technique of Lux. Thoracic distributions of the DeltaST values were displayed on a torso figure, including locations of the 18 lead locations and points of maximal ST elevation and depression. The 192 estimated body surface unipolar leads were compared with 18-lead ECGs (bipolar and unipolar). During 53 left circumflex occlusions, the maximal deltaST elevation was always located in the 18-lead ECG, with the most frequent locations at leads III, II (41%), V7-8 (34%), and V5-6 (25%). The maximal deltaST depression was located outside the 18-lead ECG (89%), with the most frequent locations above standard lead V2 (67%) and V3 (14%). During 16 proximal right coronary artery occlusions, the maximal deltaST elevation was always located in the 18-lead ECG, with the most frequent locations at leads III (81%) and V2-3R (13%). The maximal deltaST depression was located outside the 18-lead ECG (93%), with the most frequent locations above standard lead V2 (50%), V3 (14%), and V4 (14%). We conclude that maximal deltaST elevation is always located in the 18-lead ECG and maximal deltaST depression is frequently located outside of 18-lead ECG during left circumflex and proximal right coronary artery occlusions. Future studies are required to determine the bipolar leads for the 192 estimated body surface potential mapping leads.

Multilead ST-segment monitoring in patients with acute coronary syndromes: a consensus statement for healthcare professionals. ST- Segment Monitoring Practice Guideline International Working Group.

BACKGROUND: ST-segment monitoring is underused by healthcare professionals for patients with acute coronary syndromes treated in emergency departments and intensive care units. OBJECTIVE: To provide clinically practical consensus guidelines for optimal ST-segment monitoring. METHODS: A working group of key nurses and physicians met in Dallas, Tex, in November 1998. RESULTS: Consensus was reached on who should and should not have ST monitoring, goals and time frames for ST monitoring in various diagnostic categories, what electrocardiographic leads should be monitored, what equipment requirements are needed, what strategies improve accuracy and clinical usefulness of ST monitoring, and what knowledge and skills are required for safe and effective ST monitoring. CONCLUSIONS: Because changes in the ST segment can shift among various electrocardiographic leads in the same person over time owing to different ischemic mechanisms, 12-lead ST monitoring is recommended. Recommended monitoring times are as follows: myocardial infarction or unstable angina, 24 to 48 hours or until patient is event-free for 12 to 24 hours; chest pain prompting a visit to an emergency department, 8 to 12 hours; catheter-based interventions with less definitive interventional outcomes requiring monitoring in an intensive unit, 6 to 12 hours; and cardiac surgery or noncardiac surgery in patients with coronary disease or risk factors, 24 to 48 hours. An ST measurement point of J + 60 ms makes it unlikely that measurement will coincide with the upslope of the T wave, even in patients with sinus tachycardia. Accurate and consistent lead placement and careful electrode and skin preparation are imperative to improve the clinical usefulness of ST monitoring.

Frequency of silent myocardial ischemia with 12-lead ST segment monitoring in the coronary care unit: are there sex-related differences?

BACKGROUND: Ischemia that occurs in the coronary care unit (CCU), whether symptomatic or silent, is associated with significant in-hospital and out-of-hospital complications. Studies have reported that more than 90% of ischemic episodes are silent in patients with unstable angina who are treated in the CCU with maximal medical therapy. Prior reports indicate that women complained more frequently of chest pain than men did. PURPOSE: The aim of this study was to compare the frequency of silent myocardial ischemia in men versus women with use of continuous 12-lead ST segment monitoring in the CCU. A secondary goal was to determine whether silent ischemia was associated with less ST segment deviation as compared with symptomatic ischemia. METHOD: Patients admitted for treatment of acute coronary syndrome in the CCU and who subsequently had 1 or more ischemic events during their monitoring period were selected for this analysis. All patients were continuously monitored (42.5 hours +/- 37.6) in the CCU with the EASI (Zymed Medical Instruments, Camarillo, Calif) 12-lead electrocardiogram (ECG) system that derives 12 leads with use of 3 information channels and 5 electrodes. RESULTS: Of 491 patients, 128 (91 men and 37 women) had at least 1 episode of transient myocardial ischemia. Men and women did not differ in their proportion of chest pain during ischemia (men 27% and women 21%, NS). For both men and women, ST segment deviation was significantly greater during symptomatic ischemia compared with silent ischemia. CONCLUSION: There are no sex-related differences in ischemic events in the CCU in regards to the variables of chest pain and ST magnitude. Therefore, because chest pain is not a reliable indicator of myocardial ischemia in the CCU, regardless of sex, patients should be adequately monitored for ischemic events.

Accuracy of the EASI 12-lead electrocardiogram compared to the standard 12-lead electrocardiogram for diagnosing multiple cardiac abnormalities.

This study was performed to compare a derived 12-lead electrocardiogram (ECG) using a simple 5-electrode lead configuration (EASI 12-lead) with the standard ECG for multiple cardiac diagnoses. Accurate diagnosis of arrhythmias and ischemia often require analysis of multiple (ideally, 12) ECG leads; however, continuous 12-lead monitoring is impractical in hospital settings. EASI and standard ECGs were compared in 540 patients, 426 of whom also had continuous 12-lead ST segment monitoring with both lead methods. Independent standards relative to a correct diagnosis were used whenever possible, for example, echocardiographic data for chamber enlargement-hypertrophy, and troponin levels for acute infarction. Percent agreement between the 2 methods were: cardiac rhythm, 100%; chamber enlargement-hypertrophy, 84%-99%; right and left bundle branch block, 95% and 97%, respectively; left anterior and posterior fascicular block, 97% and 99%, respectively; prior anterior and inferior infarction, 95% and 92%, respectively. There was very little variation between the 2 lead methods in cardiac interval measurements; however, there was more variation in P, QRS, and T-wave axes. Of the 426 patients with ST monitoring, 138 patients had a total of 238 ST events (26, acute infarction; 62, angioplasty-induced ischemia; 150, spontaneous transient ischemia). There was 100% agreement between the 2 methods for acute infarction, 95% agreement for angioplasty-induced ischemia, and 89% agreement for transient ischemia. EASI and standard 12-lead ECGs are comparable for multiple cardiac diagnoses; however, serial ECG changes (eg, T-wave changes) should be assessed using one consistent 12-lead method.

Frequency of ischemia during intracoronary ultrasound in women with and without coronary artery disease.

Myocardial ischemia is common during ICUS imaging in women with and without CAD. Although no long-term adverse effects occurred in our small sample, a larger sample of women is required to confirm our observations and to determine the precise mechanisms of ischemia. Such studies may determine whether the smaller diameter of coronary vessels in women makes the women more vulnerable than men to the occurrence of chest pain and ischemia during ICUS. Although ICUS is valuable in guiding coronary interventions, disposable catheters are costly. Studies are required to assess the cost-benefit ratio of incorporating ICUS with coronary interventional procedures. Until more is known, we recommend that nurses educate patients about ICUS, monitor them closely for ischemia and arrhythmias during the procedure, and consider obtaining 12-lead ECGs when patients undergo and ICUS procedure.

Peak time of occurrence of myocardial ischemia in the coronary care unit.

BACKGROUND: The onset of acute myocardial infarction and sudden cardiac death has a circadian variation, with the peak occurrence between 6 AM and 12 noon. OBJECTIVES: To determine if a circadian variation exists for transient myocardial ischemia in patients admitted to the coronary care unit with unstable coronary syndromes. METHODS: The sample was selected from patients enrolled in a prospective clinical trial who had had ST-segment monitoring for at least 24 hours and had had at least one episode of transient ischemia. The 24-hour day was divided into 6-hour periods, and comparisons were made between the 4 periods. RESULTS: In 99 patients, 61 with acute myocardial infarction and 38 with unstable angina, a total of 264 (mean +/- SD, 3 +/- 2) ischemic events occurred. Patients were more likely to have ischemic events between 6 AM and noon than at other times. A greater proportion of patients complained of chest pain between 6 AM and noon than during the other 3 periods. However, more than half the patients never complained of chest pain during ischemia between 6 AM and noon. CONCLUSION: Transient ischemia occurs throughout the 24-hour day; however, ischemia occurs more often between 6 AM and noon. An important nursing intervention for detecting ischemia is continuous electrocardiographic monitoring of the ST segment, even during routine nursing care activities, which are often at a peak during the vulnerable morning hours.