[Experimental Lassa fever in hamadryas baboons]. / Eksperimental'naia likhoradka Lassa u pavianov gamadrilov.

Intramuscular or aerogenic inoculation of baboons with Lassa virus reproduced a severe form of the disease which clinically, pathoanatomically and virologically resembles the severe form of human Lassa fever reported in the literature. The severity of monkey infection is demonstrated by rapid development of symptoms of general toxicity in the presence of fever, manifestations of hemorrhagic diathesis, high level of viremia and isolation of the causative agent from nasopharyngeal washings.

[The therapeutic efficacy of ribamidil and virazole in experimental Lassa fever in monkeys]. / Terapevticheskaia éffektivnost' ribamidila i virazola pri éksperimental'noi likhoradke Lassa u obez'ian.

The therapeutic efficacy of ribamydil and virasol was evaluated in experimental Lassa fever in monkeys which received these drugs at various intervals after the onset of the clinical illness. Ribamydil or virasol administered in the first day of fever protected from death 60% to 66% of the infected animals, but when the drugs were given 2 days after the onset of fever the number of survivors declined to 0.20%. When the treatment was started 4 days after the onset of fever none of the drugs prevented deaths of Lassa virus-infected baboons.

[Comparative evaluation of the antiviral efficacy of virazole and ribamidil in experimental Lassa fever in monkeys]. / Sravnitel'naia otsenka protivovirusnoi éffektivnosti virazola i ribamidila pri éksperimental'noi likhoradke Lassa u obez'ian.

Lassa virus administered to monkeys aerogenically induced in these laboratory animals a fatal disease modelling the severe course of human Lassa fever. It was demonstrated experimentally that ribamydil, a Soviet analogue of virasol, as well as foreign commercial virasol was therapeutically effective in experimental Lassa fever in aerogenically infected monkeys.