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J Biomed Mater Res A ; 96(1): 230-8, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21105172

RESUMEN

We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials.


Asunto(s)
Regeneración Ósea/fisiología , Sustitutos de Huesos/química , Implantes Experimentales , Cráneo/patología , Cráneo/cirugía , Animales , Materiales Biocompatibles/química , Cerámica/química , Humanos , Masculino , Ensayo de Materiales , Ratas , Ratas Wistar , Cicatrización de Heridas
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