Tiempo requerido para la administración y evaluación del Cuestionario Prunape Pre-Pesqusia (CPPP) / Time needed for the adminsitration and evaluation of the Prunape Pre- Pesquisia (CPPP) questionnaire

Con el objetivo de evaluar el tiempo que toma la administración de Cuestionario PrunPe Pre-Pesquisa (CPPP), diseñado en Acumar para detectar en forma confiable aquellos niños con alto riesgo de no pasar la Prueba Nacional de Pesquisa (PRUNAPE), se midió en forma ciega a 98 madres con sus niños, el tiempo que lleva su llenado y evaluación de dos formas: autoadministrado (por la madre), y administrado por personal de salud. Se evaluaron dos partes: a) la administración, y b) la evaluación final (pasa / no pasa el cuestionario). El tiempo lo midieron los mismos 11 profesionales de la salud que administraron el cuestionario, con cronómetros de teléfonos celulares, y con la precisión de un segundo. Los cuestionarios son cinco, uno para cada grupo de edad: 6 a 11, 12 a 17, 18 a 29, 30 a 47, 48 a 71 meses. La mediana del tiempo total de toma del cuestionario fue de 7 minutos (´) 33segundos (ô), y 4´47ö y 12¿19ö para los percentiles 10° y 90° respectivamente. Los tiempos no fueron los mismos para los cinco formularios ni para los que pasaron o no pasaron el cuestionario. El análisis de variancia (P 0.01)mostró que las dos variables influyen significativamente en la duración de la toma: si el niño no pasa y el niño es mayor de 30 meses, el tiempo es más largo. El CPPP resulta una herramienta que se administra en poco tiempo, lo que la hace costo-efectiva para seleccionar los niños a quienes es altamente necesario administrarle la Prueba Nacional de Pesquisa en programas de tamizaje en grandes grupos de población

Tiempo requerido para la administración y evaluación del Cuestionario Prunape Pre-Pesqusia (CPPP) / Time needed for the adminsitration and evaluation of the Prunape Pre- Pesquisia (CPPP) questionnaire

Con el objetivo de evaluar el tiempo que toma la administración de Cuestionario PrunPe Pre-Pesquisa (CPPP), diseñado en Acumar para detectar en forma confiable aquellos niños con alto riesgo de no pasar la Prueba Nacional de Pesquisa (PRUNAPE), se midió en forma ciega a 98 madres con sus niños, el tiempo que lleva su llenado y evaluación de dos formas: autoadministrado (por la madre), y administrado por personal de salud. Se evaluaron dos partes: a) la administración, y b) la evaluación final (pasa / no pasa el cuestionario). El tiempo lo midieron los mismos 11 profesionales de la salud que administraron el cuestionario, con cronómetros de teléfonos celulares, y con la precisión de un segundo. Los cuestionarios son cinco, uno para cada grupo de edad: 6 a 11, 12 a 17, 18 a 29, 30 a 47, 48 a 71 meses. La mediana del tiempo total de toma del cuestionario fue de 7 minutos (´) 33segundos (“), y 4´47” y 12¨19” para los percentiles 10° y 90° respectivamente. Los tiempos no fueron los mismos para los cinco formularios ni para los que pasaron o no pasaron el cuestionario. El análisis de variancia (P 0.01)mostró que las dos variables influyen significativamente en la duración de la toma: si el niño no pasa y el niño es mayor de 30 meses, el tiempo es más largo. El CPPP resulta una herramienta que se administra en poco tiempo, lo que la hace costo-efectiva para seleccionar los niños a quienes es altamente necesario administrarle la Prueba Nacional de Pesquisa en programas de tamizaje en grandes grupos de población.

With the aim to evaluate the time to administer the PrunPe Pre-Pesquisa Questionnaire (CPPP), designed in Acumar to reliably identify those children at high risk of not passing the National Screening Test (PRUNAPE)....

Benign adenomyoepithelioma of the breast: imaging findings mimicking malignancy and histopathological features.

Adenomyoepithelioma of the breast is a rare neoplasm. We present a case of a benign adenomyoepithelioma of the breast in an asymptomatic 60-year-old woman. This report illustrates the mammogram, ultrasound, and magnetic resonance appearances of this unusual lesion, with histopathological correlation.

A novel mutation (K317M) in the MAPT gene causes FTDP and motor neuron disease.

BACKGROUND: Frontotemporal dementia with parkinsonism is often linked to chromosome 17 and is related to mutations in the MAPT gene. In some families the genetic basis is still unknown. The authors report two pedigrees with FTDP-17 harboring a novel mutation (K317M) in exon 11 in the MAPT gene. METHODS: The authors identified two apparently unrelated pedigrees with an autosomal dominant neurodegenerative condition. Thirteen patients were examined and eight autopsies were performed. RESULTS: Mean age at onset was 48 years. Mean disease duration was 6 years. Dysarthria often heralded the disease. All cases had parkinsonism and pyramidalism and half of them had amyotrophy. Behavioral or personality changes were not a prominent feature. Cognitive decline appeared late in the evolution. Neuropathologically, a massive degeneration of the substantia nigra without Lewy bodies was a constant finding. A variable degree of frontotemporal atrophy was found. Corticospinal tract degeneration and anterior horn neuron loss were present in six of seven autopsies in which the spinal cord was examined. An extensive deposition of abnormal tau protein in a mixed pattern (neuronal, glial) was observed. Pick's bodies were not seen. Biochemical analysis of tau revealed two bands of 64 and 68 kDa. CONCLUSION: Genetic analysis revealed the same novel mutation (K317M) in exon 11 of the MAPT gene in both pedigrees. A common haplotype between members of the two pedigrees suggests that they belong to the same family.

Adenosarcoma ovárico con componente heterólogo / Ovarian adenosarcoma with a heterologous component

El adenosarcoma mülleriano es un tumor bifásico constituido por un componente glandular benigno, ocasionalmente con atipias, asociado a un componente mesenquimal maligno. El adenosarcoma ovárico tiene un peor pronóstico que su homónimo uterino. En dos tercios de los casos se produce recidiva tumoral y casi siempre en los primeros 5 años tras el diagnóstico. En pacientes en estadio I, la edad menor a 53 años, la rotura tumoral, el alto grado y el sobrecrecimiento estromal se asocian a una alta tasa de recidiva. Presentamos un caso de adenosarcoma ovárico en estadio Ia diagnosticado en nuestro centro, con recidiva precoz, y revisamos la bibliografía (AU)

Mullerian adenosarcoma is a bifasic tumour composed of a benign glandular component, occasionally with atypical cells, associated with a malignant mesenchymal component. The sarcomatous portion of the adenosarcoma may vary from low to very high grade, and its clinical behavior may be inactive or aggressive. Generally they originate in the uterus. Extrauterine sites are infrequent, but may be in the ovaries, fallopian tubes or the peritoneal mesothelium. We describe a case of ovarian adenosarcoma with early pelvic recurrence, and review the literature (AU)

Carcinoma mamario infiltrante tras mastectomía subcutánea / Infiltrating breast cancer alter subcutaneous mastectomy

Aunque la mastectomía subcutánea es una técnica quirúrgica que pretende eliminar todo el tejido mamario macroscópico, conservando el complejo areola-pezón, suele quedar tejido glandular residual en la zona retroareolar, cola de mama y colgajos cutáneos. Por consiguiente, existe la posibilidad de desarrollar carcinoma mamario en este tejido residual. Describimos un caso de carcinoma mamario infiltrante en una paciente en la que previamente se le había realizado una mastectomía subcutánea por presentar un carcinoma intraductal extenso tipo comedo en el seno de un fibroadenoma, que sobrepasaba la cápsula de éste

Although subcutaneous mastectomy aims to remove the entire macroscopic breast gland while conserving the nipple-areola complex, some residual glandular tissue usually remains in the nipple, subareolar region, axillary tail and skin flaps. Consequently, there is a risk of developing breast cancer in the residual tissue. We describe the case of a patient with infiltrating breast cancer who had previously undergone subcutaneous mastectomy for an extensive comedo-type intraductal carcinoma within a fibroadenoma that spread through the fibroadenoma capsule

Tumor phyllodes maligno con estroma liposarcomatoso / Malignant phyllodes tumour with liposarcomatous stroma

No disponible

Carcinoma mamario con células gigantes osteoclast-like / Breast cancer with osteoclast-like giant cells

Presentamos un caso de carcinoma mamario con células gigantes multinucleadas tipo osteoclast-like en el estroma tumoral. Mostramos iconografía y comentamos las características clínicas, anatomopatológicas, inmunohistoquímicas, fisiopatológicas y pronósticas de este tipo de carcinoma mamario poco frecuente (AU)

Gliosarcoma. Case report with immunohistochemical study.

A typical case of gliosarcoma in a 74 year-old woman is reported. The exact origin of sarcomatous areas of this tumor has been a matter of debate. Our immunohistochemical findings, using a panel of antibodies (GFAP), vimentin, keratins, F-VIII related antigen, muscle specific actin, KP-1 and HMB-45), support its undifferentiated nature. The literature concerning this topic is reviewed and briefly discussed.

Extraskeletal myxoid chondrosarcoma. A clinicopathologic and immunohistochemical study of two cases.

Two extraskeletal myxoid chondrosarcomas arising on the left lower extremity of two women, aged 48 and 72 years, respectively, are reported. One case mimicked clinically an organized hematoma. By light microscopy, they showed a lobular architecture. Anastomosing cords of cells lying in a myxoid background were the histologic hallmark. Based on conventional criteria, they were classified as neoplasms of low (G1) and intermediate (G2) grade malignancy. Both cases were strongly positive for S-100 protein and vimentin. Follow-up confirmed the low aggressiveness of this entity.

Frozen section diagnosis in a jugulo-tympanic paraganglioma.

The light microscopy and immunohistochemical findings of a jugulo-tympanic paraganglioma occurring in a 29-year-old man are reported. Diagnostic difficulties from frozen sections are stressed and selected literature is briefly commented upon.

Papillary carcinoma of the breast. Fine needle aspiration cytology (FNAC) of two cases.

Cytologic findings of two cases of infiltrating papillary carcinoma of the breast are presented. Both cases showed highly cellular smears, prominent papillary configuration, and cohesive groups of polygonal cells with bland nuclei and scarce mitoses. Bipolar cells were not observed. A clean background with hemorrhage, lymphocytes and hemosiderin-laden macrophages was also found. Histologic sections confirmed the initial diagnosis and proved their infiltrating nature. Literature concerning its cytologic differential diagnosis is briefly reviewed and commented.

Rhabdomyoma of the vagina.

A case of vaginal rhabdomyoma in 35-year-old healthy woman is presented. The lesion, a pedunculated polyp measuring 1.2 cm in diameter, was located in the anterior wall of the vagina. This is an extremely rare entity that pursues a benign course. Light and immunohistochemical features are commented and selected literature briefly reviewed.

Inflammatory pseudotumor of the liver. Report of a case and literature review.

The radiologic and histologic features of an inflammatory pseudotumor of the liver in a 62-year-old man are presented. The lesion was coincidentally discovered during clinical work-up of an acute pancreatitis caused by choledocholithiasis. Malignancy was suspected in the light of the radiologic presentation. To our knowledge, only 23 cases of inflammatory pseudotumor of the liver have appeared in the international literature. Its etiology remains unknown, although reactive-inflammatory or infectious mechanisms have been suggested. The present case seemed to be associated with bile flow obstruction, as the mass partially regressed following cholecystectomy and Vaterian sphincterotomy. Therefore, a hypothetical obstructive pathogenetic mechanism is considered. We conclude that this tumor-like condition must be considered in the differential diagnosis of solid masses in the liver.

Intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. A clinicopathologic study of 6 cases.

The clinical and pathologic features of 6 cases of intestinal-type adenocarcinoma of the sinonasal region are presented. These cases were collected in a 17 year period (1972-1988) and account for less than 4% of malignancies of this region in our records for this period. All of the patients were men aged 48 to 82 years (mean, 54 years). Previous exposure to wood dust was reported in 1 case. Radiographic studies, especially computerized tomography, were of critical importance to delineate the extent of tumors. Nasal obstruction was the most common complaint. Duration of symptoms prior to diagnosis is available in 5 cases and ranged from 5 to 36 months (mean 18 months). Surgical treatment was performed in 4 patients (of palliative type in 2) followed by radiotherapy in 3. Histopathology revealed tubulo-papillary (5 cases) and mucinous (1 case) patterns. Follow-up is available in all patients (range 0 to 108 months), 50% of whom are still alive. In our series, only 1 patient has survived more than 5 years. Data pooled from the literature reveal that 53% of patients have experienced local recurrences following therapy, and 60% have died of their disease. Of these deaths, 80% occurred within 5 years of diagnosis.