RESUMEN
Mycobacterium lentiflavum is a nontuberculous, slowly growing mycobacterium usually recognized as a contaminant. Here, we report a case of disseminated M. lentiflavum infection responsible for hemophagocytic lymphohistocytosis in a heart-transplanted man.
Asunto(s)
Trasplante de Corazón , Linfohistiocitosis Hemofagocítica/complicaciones , Linfohistiocitosis Hemofagocítica/diagnóstico , Infecciones por Mycobacterium no Tuberculosas/diagnóstico , Infecciones por Mycobacterium no Tuberculosas/microbiología , Micobacterias no Tuberculosas/aislamiento & purificación , Anciano , Humanos , Masculino , Micobacterias no Tuberculosas/clasificaciónRESUMEN
INTRODUCTION: ANCA vasculitis may involve the skin and develop slowly without specific histology, and without autoantibodies. CASE REPORT: We report a 50-year-old woman who experienced bilateral mastectomy because of ulcero-necrotic, non-specific inflammatory cutaneous lesions of the breasts. First considered by others as a malinger patient, she developed oto-neurological lesions leading to the diagnosis of Wegener's granulomatosis. Five years later, specific antibodies of the disease were present. CONCLUSION: Cutaneous involvement by ANCA vasculitis can be isolated for a long time. Physicians must have a high degree of suspicion to avoid diagnostic delay of ANCA vasculitis.
Asunto(s)
Anticuerpos Anticitoplasma de Neutrófilos/sangre , Granulomatosis con Poliangitis/diagnóstico , Factores Inmunológicos/sangre , Biomarcadores/sangre , Mama/patología , Diagnóstico Tardío , Diagnóstico Diferencial , Quimioterapia Combinada , Femenino , Glucocorticoides/uso terapéutico , Granulomatosis con Poliangitis/sangre , Granulomatosis con Poliangitis/tratamiento farmacológico , Granulomatosis con Poliangitis/cirugía , Humanos , Inmunosupresores/efectos adversos , Inmunosupresores/uso terapéutico , Simulación de Enfermedad , Mastectomía , Persona de Mediana Edad , Insuficiencia del Tratamiento , Resultado del TratamientoRESUMEN
INTRODUCTION: Ischemic cholangitis in intensive care unit is a recently reported liver disease in patients who have had a prolonged mechanical ventilation and vasopressive drug support for multiple organ deficiency. Prognosis is usually poor and the only life-saving therapy is liver transplantation despite ursodesoxycholic acid treatment. CASE REPORT: We report a 63-year-old man who presented with a sclerosis cholangitis after a month in intensive care unit, effectively treated with fenofibrate and ursodesoxycholic acid. Recent reports underline fenofibrate efficacy in the treatment of primary biliary cirrhosis, especially in association with ursodesoxycholic acid. This treatment has prevented liver transplantation for our patient with a correct quality of life. CONCLUSION: The addition of fibrate to ursodesoxycholic acid improves persistent cholestasis in sclerosing cholangitis.
Asunto(s)
Colangitis Esclerosante/tratamiento farmacológico , Colangitis Esclerosante/etiología , Cuidados Críticos , Fenofibrato/administración & dosificación , Ácido Ursodesoxicólico/administración & dosificación , Colagogos y Coleréticos/administración & dosificación , Colagogos y Coleréticos/uso terapéutico , Fenofibrato/uso terapéutico , Humanos , Hipolipemiantes/administración & dosificación , Hipolipemiantes/uso terapéutico , Unidades de Cuidados Intensivos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Ácido Ursodesoxicólico/uso terapéuticoAsunto(s)
Dolor de Espalda/etiología , Diarrea/complicaciones , Arterias Mesentéricas/patología , Placa Aterosclerótica/diagnóstico , Pérdida de Peso , Dolor Abdominal/etiología , Adulto , Angiodisplasia/complicaciones , Angiodisplasia/etiología , Caquexia/etiología , Constricción Patológica/complicaciones , Constricción Patológica/diagnóstico , Diagnóstico Diferencial , Diarrea/etiología , Femenino , Infecciones por Helicobacter/complicaciones , Humanos , Nutrición Parenteral/métodos , Placa Aterosclerótica/complicaciones , Factores de Riesgo , Fumar/efectos adversos , Gastropatías/complicaciones , Úlcera Gástrica/complicaciones , Resultado del TratamientoRESUMEN
Links between Takayasu's arteritis (TA) and tuberculosis are discussed in the literature. We report the case of a Caucasian woman who was first seen for a regressive fever, associated with a normal clinical and chest and abdominal CT-scan examination. A minor granulomatous hepatitis was documented. She had no symptoms for the following four years. A second episode of persisting fever led to the diagnosis of simultaneous occurrence of diffuse TA and severe disseminated tuberculosis. Both affections were treated and the patient was still in good health after three years of follow-up. Simultaneous occurrence of both diseases in our observation supports evidence for a relationship between those two granulomatous diseases.
Asunto(s)
Arteritis de Takayasu/complicaciones , Tuberculosis Miliar/complicaciones , Corticoesteroides/uso terapéutico , Antituberculosos/uso terapéutico , Quimioterapia Combinada , Femenino , Humanos , Persona de Mediana Edad , Mycobacterium tuberculosis/aislamiento & purificación , Inhibidores de Agregación Plaquetaria/uso terapéutico , Índice de Severidad de la Enfermedad , Arteritis de Takayasu/diagnóstico , Arteritis de Takayasu/tratamiento farmacológico , Resultado del Tratamiento , Tuberculosis Miliar/diagnóstico , Tuberculosis Miliar/tratamiento farmacológicoRESUMEN
We report a case of hypocomplementemic urticarial vasculitis heralding a relapsing polychondritis in a 63-year-old woman. The patient, who had suffered in the past from polymyalgia rheumatica, suddenly experienced a generalized urticarial eruption with a dramatic decrease in C4 complement fraction and the presence of anti-C1q antibodies. Two months later, an ear chondritis occurred and the patient rapidly responded to steroids and dapsone. To our knowledge, this association has never been reported.
Asunto(s)
Potenciales de Acción , Marcapaso Artificial , Músculos Pectorales/fisiología , Anciano , Falla de Equipo , Humanos , MasculinoAsunto(s)
Prótesis Vascular/efectos adversos , Endocarditis Bacteriana/diagnóstico , Enterobacter cloacae , Infecciones por Enterobacteriaceae/diagnóstico , Infecciones Relacionadas con Prótesis/diagnóstico , Anciano , Endocarditis Bacteriana/etiología , Infecciones por Enterobacteriaceae/etiología , Humanos , Masculino , Infecciones Relacionadas con Prótesis/etiologíaAsunto(s)
Leucemia Mielomonocítica Aguda/diagnóstico , Leucemia Mielomonocítica Aguda/patología , Infiltración Leucémica , Piel/patología , Úlcera/etiología , Enfermedades de la Vulva/etiología , Adulto , Diagnóstico Diferencial , Femenino , Estudios de Seguimiento , Humanos , Leucemia Mielomonocítica Aguda/complicaciones , Pronóstico , Factores de TiempoRESUMEN
INTRODUCTION: Ictero-hemorrhagic leptospirosis is an endemic disease in France. Weil's disease, a form of leptospirosis, is well known. Fort Bragg fever is characterized by a constant pretibial papular lesion. First described in the USA, this non icteric form of leptospirosis is usually benign. We report the first French case of a mixed form of leptospirosis. EXEGESIS: A 52-year-old man living in South East France suffered from fever and myalgias associated with a pretibial papular lesion. A severe icterus appeared and permitted a diagnosis of leptospirosis. CONCLUSION: Our case recalls the clinical presentation of Fort Bragg fever, which is recognized through its inflammatory pretibial lesion associated or not with icterus.
Asunto(s)
Leptospirosis/diagnóstico , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Bilirrubina/sangre , Diagnóstico Diferencial , Humanos , Ictericia/sangre , Ictericia/complicaciones , Ictericia/diagnóstico , Leptospirosis/sangre , Leptospirosis/complicaciones , Leptospirosis/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Penicilina G/administración & dosificación , Penicilina G/uso terapéutico , Terminología como Asunto , Factores de Tiempo , Resultado del TratamientoRESUMEN
INTRODUCTION: Palpation of soft tissues constitutes part of the physical examination when faced with a patient with fever of unknown origin. Our case highlights the difficulty of diagnosis when the tumor still remains impalpable ten months after onset of fever and severe biological inflammatory process. EXEGESIS: A 49-year-old woman was admitted for fever of unknown origin associated with important biological inflammatory process. In view of her past medical history of breast carcinoma, a search for a relapse was performed and remained negative. Despite multiple investigations and repeated physical examinations, no diagnosis was obtained. Finally, [18F] fluorodoexyglucose positron emission tomography led to a diagnosis showing a high fixation located in the right thigh, related to a myxoid liposarcoma after surgical resection. CONCLUSION: Dramatic regression of fever and biological inflammatory process after surgical treatment illustrates the concept of "small tumor and fever of unknown origin", an exceptional entity but which physicians should be aware of. The role of new technical imaging with [18F] fluorodoexyglucose positron emission tomography has however to be clarified in the evaluation of fever of unknown origin.
Asunto(s)
Fiebre de Origen Desconocido/etiología , Liposarcoma/complicaciones , Neoplasias de los Tejidos Blandos/complicaciones , Neoplasias de la Mama , Femenino , Fiebre de Origen Desconocido/patología , Humanos , Inflamación , Liposarcoma/cirugía , Anamnesis , Persona de Mediana Edad , Neoplasias de los Tejidos Blandos/cirugía , Tomografía Computarizada de Emisión , Resultado del TratamientoAsunto(s)
Corticoesteroides/efectos adversos , Absceso Encefálico/etiología , Trasplante de Corazón , Nocardiosis/etiología , Prednisona/efectos adversos , Arteritis de Células Gigantes/tratamiento farmacológico , Humanos , Huésped Inmunocomprometido , Masculino , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
PURPOSE: Prothrombin gene mutation G20210A (factor II) is, in frequency, the second genetic polymorphism involved in venous thrombosis. We report a retrospective studies on 38 patients issued from our medical department, all heterozygous for the factor II mutation and a literature review. METHODS: We have studied 38 patients, all heterozygous for the factor II mutation, selected through a population of 516 tested patients issued from our medical department from 1997 to 2002. The research was performed face with history of thrombotic or obstetrical events, angiopathy or familial screening. RESULTS: Twenty out of thirty-eight patients have at least one episode of venous thrombosis: superficial thromboses, deep thromboses and/or pulmonary embolism. One case of cerebral thrombophlebitis is observed. Venous thrombotic risk factors are associated in 12 cases (60%). Four out of thirty-eight patients have one episode of arterial thrombosis: cardiovascular, peripheral or cerebral. Arterial thrombotic risk factors are associated in all cases. Median age of the first venous thrombosis is earlier than the one of arterial thrombosis (39.11 versus 49.25 years). CONCLUSION: Our studies confirms the interest to search the prothrombin gene mutation when faced with a venous thrombotic event (deep vein thrombosis and/or pulmonary embolism) with or without acquired risk factors. Its involvement in thrombotic arterial disease is still a matter of debate. Data concerning its involvement in systemic diseases and angiopathies (thromboangeitis obliterans, Raynaud's phenomenon and migraine) are still needed. Mechanisms of thromboses could be an increase of prothrombin plasma level with high thrombin synthesis.
Asunto(s)
Heterocigoto , Mutación/genética , Protrombina/genética , Embolia Pulmonar/genética , Trombosis/genética , Adulto , Anciano , Arterias , Femenino , Francia/epidemiología , Tamización de Portadores Genéticos , Pruebas Genéticas/métodos , Humanos , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Polimorfismo Genético/genética , Protrombina/metabolismo , Embolia Pulmonar/sangre , Embolia Pulmonar/epidemiología , Estudios Retrospectivos , Factores de Riesgo , Trombosis/sangre , Trombosis/epidemiología , VenasRESUMEN
The Muckle-Wells syndrome is a rare autosomal dominant disorder belonging to the group of hereditary fever syndromes. The chronic infantile neurological cutaneous and articular (CINCA) syndrome is a systemic inflammatory disorder of unknown etiology with neonatal onset. They are considered as two different entities. We report the case of a 36-year-old man suffering since birth from a nonpruritic generalized urticaria, with inflammatory flares, joint manifestations and progressive deafness requiring a bilateral hearing aid. An initial diagnosis of Muckle-Wells syndrome was made. However, the patient had an unusual clinical presentation with slightly dysmorphic facial appearance, clubbing of the fingers, mild mental retardation and papilledema. After a genetic advice, a diagnosis of CINCA syndrome was made. Search for mutations in the CIAS1 gene revealed a new mutation in a heterozygous state. This case report really raises the question of a link between these two inflammatory diseases. Further studies are needed to confirm the involvement of mutations of the CIAS1 gene in CINCA syndrome.