Asunto(s)
Leiomioma/diagnóstico , Neoplasias Gástricas/diagnóstico , Diagnóstico Diferencial , Femenino , Humanos , Leiomioma/diagnóstico por imagen , Leiomioma/cirugía , Persona de Mediana Edad , Neoplasias Gástricas/diagnóstico por imagen , Neoplasias Gástricas/cirugía , Tomografía Computarizada por Rayos X , UltrasonografíaRESUMEN
A series of omega-amino-2-hydroxy-p-fluorobutyrophenones have been synthesized to evaluate the influence exerted by a hydroxyl group in alpha-position to the carbonyl on the persistence of their neuroleptic and collateral properties. The new compounds generally did not show any neuroleptic activity while some of them were still hypotensive; this last effect, however, did not seem to be related to their alpha-adrenolytic properties.
Asunto(s)
Antipsicóticos/síntesis química , Animales , Antipsicóticos/toxicidad , Presión Sanguínea/efectos de los fármacos , Butirofenonas , Catalepsia/inducido químicamente , Fenómenos Químicos , Química , Interacciones Farmacológicas , Femenino , Humanos , Dosificación Letal Mediana , Masculino , Ratones , Actividad Motora/efectos de los fármacos , Norepinefrina/toxicidad , Ratas , Conducta Estereotipada/efectos de los fármacosRESUMEN
A series of new butyrophenones was synthesized, the aim being to reduce neuroleptic activity and enhance the hypotensive effects of this class of drugs. The compounds were screened for toxicity according to the Irwin scheme and tested in anaesthetized cats for their effects on systemic arterial pressure. The most interesting compound, i.e. 1-(4'-fluorobenzoyl)-3-pyrrolidinyl-propane, was tested also in anaesthetized rabbits, cats, and dogs and in concious dogs. Moreover its central nervous system effects were tested in rats and mice. The compound proved practically devoid of neurological effects and showed interesting hypotensive activity.