[Indices of iron metabolism in liver homogenates and leukocytes]. / Opredelenie pokazatelei obmena zheleza v gomogenatakh pecheni i leikotsitov.

Iron metabolites were measured in liver homogenates and leukocytes of patients with hereditary hemochromatosis (HHC), chronic viral hepatitis, and secondary iron overloading. Iron and ferritin levels in the liver are increased HHC, while in hepatitis only ferritin level is increased. In the leukocytes ferritin concentrations are increased both in HHC and secondary iron loading and less so in viral hepatitis. The leukocytic ferritin level decreased after a course of bleeding sessions and during maintenance therapy for HHC, which can serve as a diagnostically significant sign for evaluating the treatment efficiency.

[Regulation of erythropoiesis in patients with iron deficiency anemia]. / Reguliatsiia éritropoéza u bol'nykh zhelezodefitsitnoi anemiei.

Erythropoietin level in the blood plasma, iron metabolism, and some erythron parameters characterizing anemia expression, erythropoiesis effectiveness and processes of hemoglobin synthesis were studied in patients with iron-deficiency anemia (IDA). The results of the investigation helped the authors to establish that hormone production in IDA patients is under the control of a feedback mechanism that is functioning at a lower level as compared to other non-renal anemias. It has been suggested that optimum possible erythron functioning in IDA patients is achieved under these conditions.

[The dependence of hemoglobin and iron reserve indices on habitat conditions (sampling research in Osh Province, the Kirghiz SSR)]. / Zavisimost' pokazatelei gemoglobina i zapasov zheleza ot uslovii obitaniia (vyborochnoe issledovanie v Oshskoi oblasti Kirgizskoi SSR).

Sampling investigation of female population (896 subjects) was conducted in five regions with opposite environmental conditions. A relatively low incidence of iron deficiency anemia and high incidence of exhausted iron reserves in the women living in the high mountains indicates the participation of the adaptive-compensatory mechanisms in the development of iron-deficiency. A high rate of iron deficiency incidence in the regions of intensive tobacco growing and association of iron-deficiency anemia in women engaged in tobacco growing with their occupation suggests a possible role of this factor in the development of iron-deficiency. The analysis of cumulative probability of hemoglobin level has evidenced manifest differences in standard borderlines of this parameter for women living in high mountains, middle mountains and in valleys.