RESUMEN
BACKGROUND AND OBJECTIVE: Cognitive-behavioural treatments (CBT) and physical group exercise (PE) have both shown promising effects in reducing disability and increasing work participation among chronic low back pain (CLBP) patients. A brief cognitive intervention (BI) has previously been demonstrated to reduce work disability in CLBP. The aim of this study was to test if the effect of BI could be further increased by adding either group CBT or group PE. METHODS: A total of 214 patients, all sick listed 2-10 months due to CLBP, were randomized to BI (n = 99), BI + group CBT (n = 55) or BI + group PE (n = 60). Primary outcome was increased work participation at 12 months, whereas secondary outcomes included pain-related disability, subjective health complaints, anxiety, depression, coping and fear avoidance. RESULTS: There were no significant differences between the groups in work participation at 12 months follow-up (χ2 = 1.15, p = 0.56). No significant differences were found on the secondary outcomes either, except for a statistically significant reduction (time by group) in pseudoneurology one domain of subjective health complaints (sleep problems, tiredness, dizziness, anxiety, depression, palpitation, heat flushes) (F2,136 = 3.109, p = 0.048) and anxiety (F2,143 = 4.899, p = 0.009) for the groups BI + group CBT and BI + group PE, compared to BI alone. However, these differences were not significant in post hoc analyses (Scheffé adjusted). CONCLUSION: There was no support for an effect of the added group CBT or group PE treatments to a brief cognitive intervention in this study of patients on sick leave due to low back pain. SIGNIFICANCE: Our study demonstrates that treatments that previously were found to be effective and are included in most treatment guidelines, such as group cognitive-behavior therapy and exercise, were not effective in this given context compared to a brief, cognitive intervention. This implies that an optimized brief intervention is difficult to outperform in patients on sick leave due to low back pain.
Asunto(s)
Dolor Crónico/terapia , Terapia Cognitivo-Conductual , Terapia por Ejercicio , Dolor de la Región Lumbar/terapia , Psicoterapia Breve , Psicoterapia de Grupo , Adaptación Psicológica , Adulto , Evaluación de la Discapacidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Ausencia por Enfermedad , Resultado del TratamientoRESUMEN
BACKGROUND: The workplace is used as a setting for interventions to prevent and reduce sickness absence, regardless of the specific medical conditions and diagnoses. AIMS: To give an overview of the general effectiveness of active workplace interventions aimed at preventing and reducing sickness absence. METHODS: We systematically searched PubMed, Embase, Psych-info, and ISI web of knowledge on 27 December 2011. Inclusion criteria were (i) participants over 18 years old with an active role in the intervention, (ii) intervention done partly or fully at the workplace or at the initiative of the workplace and (iii) sickness absence reported. Two reviewers independently screened articles, extracted data and assessed risk of bias. A narrative synthesis was used. RESULTS: We identified 2036 articles of which, 93 were assessed in full text. Seventeen articles were included (2 with low and 15 with medium risk of bias), with a total of 24 comparisons. Five interventions from four articles significantly reduced sickness absence. We found moderate evidence that graded activity reduced sickness absence and limited evidence that the Sheerbrooke model (a comprehensive multidisciplinary intervention) and cognitive behavioural therapy (CBT) reduced sickness absence. There was moderate evidence that workplace education and physical exercise did not reduce sickness absence. For other interventions, the evidence was insufficient to draw conclusions. CONCLUSIONS: The review found limited evidence that active workplace interventions were not generally effective in reducing sickness absence, but there was moderate evidence of effect for graded activity and limited evidence for the effectiveness of the Sheerbrooke model and CBT.
Asunto(s)
Absentismo , Terapia Cognitivo-Conductual , Servicios de Salud del Trabajador , Salud Laboral , Reinserción al Trabajo , Ausencia por Enfermedad , Lugar de Trabajo , Ejercicio Físico , Educación en Salud , HumanosRESUMEN
Psychological distress may be causally related to multiple, unexplained somatic symptoms. We have investigated job stress, coping strategies and subjective health complaints in patients with subjective food hypersensitivity. Sixty-four patients were compared with 65 controls. All participants filled in questionnaires focusing on job stress, job demands and control, work environment, coping strategies and subjective health complaints. Compared with controls, patients scored significantly lower on job stress and job demands, and significantly higher on authority over job decisions. Coping strategies and satisfaction with work environment did not differ significantly between the two groups, but the patients reported significantly more subjective health complaints than the controls. Scores on job stress and job demands were generally low in patients with subjective food hypersensitivity. It is unlikely, therefore, that the patients' high scores on subjective health complaints are causally related to the work situation.
Asunto(s)
Hipersensibilidad a los Alimentos/psicología , Satisfacción en el Trabajo , Enfermedades Profesionales/psicología , Trastornos Somatomorfos/psicología , Estrés Psicológico/complicaciones , Adaptación Psicológica , Adulto , Medicina Familiar y Comunitaria , Femenino , Hipersensibilidad a los Alimentos/diagnóstico , Hipersensibilidad a los Alimentos/inmunología , Humanos , Conducta de Enfermedad , Inmunoglobulina E/sangre , Control Interno-Externo , Pruebas Intradérmicas , Masculino , Persona de Mediana Edad , Inventario de Personalidad/estadística & datos numéricos , Psicometría , Medio Social , Carga de Trabajo/psicologíaRESUMEN
BACKGROUND: Seven previous systematic reviews (SRs) have evaluated back schools, and one has evaluated brief education, with the latest SR including studies until November 2004. The effectiveness of fear-avoidance training has not been assessed. PURPOSE: To assess the effectiveness of back schools, brief education, and fear-avoidance training for chronic low back pain (CLBP). STUDY DESIGN: A SR. METHODS: We searched the MEDLINE database of randomized controlled trials (RCT) until August 2006 for relevant trials reported in English. Assessment of effectiveness was based on pain, disability, and sick leave. RCTs that reported back schools, or brief education as the main intervention, were included. For fear-avoidance training, evaluation of domain-specific outcome was required. Two reviewers independently reviewed the studies. RESULTS: Eight RCTs including 1,002 patients evaluated back schools, three studies were of high quality. We found conflicting evidence for back schools compared with waiting list, placebo, usual care, and exercises, and a cognitive behavioral back school. Twelve trials including 3,583 patients evaluated brief education. Seven trials, six of high quality, evaluated brief education in the clinical setting. We found strong evidence of effectiveness on sick leave and short-term disability compared with usual care. We found conflicting or limited evidence for back book or Internet discussion (five trials, two of high quality) compared with waiting list, no intervention, massage, yoga, or exercises. Three RCTs of high quality, including 364 patients, evaluated fear-avoidance training. We found moderate evidence that there is no difference between rehabilitation including fear-avoidance training and spinal fusion. CONCLUSIONS: Consistent recommendations are given for brief education in the clinical setting, and fear-avoidance training should be considered as an alternative to spinal fusion, and back schools may be considered in the occupational setting. The discordance between reviews can be attributed differences in inclusion criteria and application of evidence rules.
Asunto(s)
Terapia Cognitivo-Conductual/métodos , Dolor de la Región Lumbar/psicología , Dolor de la Región Lumbar/terapia , Educación del Paciente como Asunto/métodos , Reacción de Prevención , Enfermedad Crónica , Miedo , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Instituciones AcadémicasRESUMEN
This chapter summarizes the European Guidelines for Prevention in Low Back Pain, which consider the evidence in respect of the general population, workers and children. There is limited scope for preventing the incidence (first-time onset) of back pain and, overall, there is limited robust evidence for numerous aspects of prevention in back pain. Nevertheless, there is evidence suggesting that prevention of various consequences of back pain is feasible. However, for those interventions where there is acceptable evidence, the effect sizes are rather modest. The most promising approaches seem to involve physical activity/exercise and appropriate (biopsychosocial) education, at least for adults. Owing to its multidimensional nature, no single intervention is likely to be effective at preventing the overall problem of back pain, although there is likely to be benefit from getting all the players onside. However, innovative studies are required to better understand the mechanisms and delivery of prevention in low back pain.
Asunto(s)
Terapia por Ejercicio , Dolor de la Región Lumbar/prevención & control , Humanos , Aparatos Ortopédicos , Educación del Paciente como Asunto , Guías de Práctica Clínica como Asunto , Equipos de SeguridadRESUMEN
INTRODUCTION: This review argues that "subjective health complaints" is a better and neutral term for "unexplained medical symptoms." The most common complaints are musculoskeletal pain, gastrointestinal complaints and "pseudoneurology" (tiredness, sleep problems, fatigue, and mood changes). These complaints are common in the general population, but for some these complaints reach a level that requires care and assistance. THEORETICAL ASSUMPTIONS: We suggest that these complaints are based on sensations from what in most people are normal physiological processes. In some individuals these sensations become intolerable. In some cases it may signal somatic disease, in most cases not. Cases without somatic disease, or with minimal somatic findings, occur under diagnoses like burnout, epidemic fatigue, multiple chemical sensitivity, chronic musculoskeletal pain, chronic low back pain, chronic fatigue syndrome, and fibromyalgia. These complaints are particularly common in individuals with low coping and high levels of helplessness and hopelessness. CONCLUSION: The psychobiological mechanisms for this is suggested to be sensitization in neural loops maintained by sustained attention and arousal.
Asunto(s)
Cognición , Rol del Enfermo , Trastornos Somatomorfos/epidemiología , Estrés Psicológico/psicología , Fatiga/epidemiología , Enfermedades Gastrointestinales/epidemiología , Humanos , Trastornos del Humor/epidemiología , Enfermedades Musculoesqueléticas/epidemiología , Dolor/epidemiología , Teoría Psicológica , Trastornos del Sueño-Vigilia/epidemiologíaRESUMEN
The association between low socioeconomic status and poor health is well established. Empirical studies suggest that psychosocial factors are important mediators for these effects, and that the effects are mediated by psychobiological mechanisms related to stress physiology. The objective of this paper is to explore these psychobiological mechanisms. Psychobiological responses to environmental challenges depend on acquired expectancies (learning) of the relations between responses and stimuli. The stress response occurs whenever an individual is faced with a challenge. It is an essential element in the total adaptive system of the body, and necessary for adaptation, performance and survival. However, a period of recovery is necessary to rebalance and to manage new demands. Individuals with low social status report more environmental challenges and less psychosocial resources. This may lead to vicious circles of learning to expect negative outcomes, loss of coping ability, strain, hopelessness and chronic stress. This type of learning may interfere with the recovery processes, leading to sustained psychobiological activation and loss of dynamic capacity to respond to new challenges. Psychobiological responses and health effects in humans and animals depend on combinations of demands and expected outcomes (coping, control). In studies of humans with chronic psychosocial stress, and low SES, cortisol baseline levels were raised, and the cortisol response to acute stress attenuated. Low job control was associated with insufficient recovery of catecholamines and cortisol, and a range of negative health effects. Biological effects of choice of lifestyle, which also depends on the acquired outcome expectancies, reinforce these direct psychobiological effects on health. The paper concludes that sustained activation and loss of capacity to respond to a novel stressor could be a cause of the higher risk of illness and disease found among people with lower SES.
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Adaptación Psicológica/fisiología , Indicadores de Salud , Clase Social , Estrés Psicológico/fisiopatología , Humanos , Estilo de Vida , Factores Socioeconómicos , TiempoRESUMEN
Our objective was to evaluate the effect of 12 weeks of stress management training (SMT), physical exercise (PE) and an integrated health programme (IHP) in a worksite setting on subjective health complaints. To do this, we randomly split 860 employees into the following groups: control (n = 344), PE (n = 189), IHP (comprising physical exercise and health information) (n = 165) and SMT (n = 162). There were no significant effects on subjective health complaints, sick leave or job stress. However, strong and specific positive effects were experienced for the particular goal areas defined for each intervention. The PE group showed improved general health, physical fitness and muscle pain, while the SMT group showed improved stress management. The IHP group showed the strongest effects, affecting most goals set for treatment.
Asunto(s)
Terapia por Ejercicio/métodos , Estrés Psicológico/prevención & control , Adaptación Fisiológica , Adulto , Femenino , Humanos , Masculino , Noruega , Servicios de Salud del Trabajador/normas , Educación del Paciente como Asunto , Ausencia por Enfermedad , Diseño de Software , Lugar de TrabajoRESUMEN
OBJECTIVE: There is now greater public concern about how features of modern life pose threats to personal health. In two studies, we investigated the relationship between individuals' worries about modernity affecting health to symptom reports, perceptions of health and health care utilization. METHODS: In the first study, 526 University students completed a questionnaire measuring modern health worries (MHW), symptom reports and health perceptions. A second study utilized an existing national survey database of 7869 New Zealanders. Part of the survey examined people's concerns of modernity affecting their health in the past 12 months, as well as the use of conventional medical and alternative health care. RESULTS: We found concerns about modernity affecting health were made up of four major components: environmental pollution, toxic interventions, tainted food and radiation. MHW were significantly associated with somatic complaints and ratings of the importance of health to the individual. We also found individuals with high levels of MHW had a higher rate of food intolerance and chronic fatigue syndrome (CFS). In the second study, we found MHW to be associated with medical care utilization, particularly of alternative health practitioners. CONCLUSIONS: The results of these studies suggest concerns about modernity do cause changes in the way individuals interpret somatic information and may play a role in undermining perceptions of health. The area of MHW is worthy of study and may hold importance for understanding aspects of functional disorders.
Asunto(s)
Actitud Frente a la Salud , Servicios de Salud/estadística & datos numéricos , Estado de Salud , Estrés Psicológico , Adolescente , Adulto , Recolección de Datos , Contaminantes Ambientales/efectos adversos , Femenino , Contaminación de Alimentos , Humanos , Masculino , Percepción , Contaminantes Radiactivos/efectos adversos , Trastornos Somatomorfos , Encuestas y CuestionariosRESUMEN
The purpose of this presentation is to discuss the possibility that sensitization is a psychobiological mechanism underlying not only multiple chemical sensitivity (MCS), but a much more general cluster of illness, referred to as "subjective health complaints". Sustained arousal, or sustained "stress" responses, may be an important factor for the development of these conditions. Patients with subjective complaints without objective changes are sometimes referred to as having "fashionable diagnoses" or "unexplained symptoms". They may be given diagnoses like MCS, epidemic fatigue, chronic fatigue syndrome, burnout, stress, a variety of intoxications, environmental illness, radiation, multiple chemical hypersensitivity, food intolerance, functional dyspepsia, irritable bowel, myalgic encephalitis, postviral syndrome, yuppie flu, fibromyalgia, or vital exhaustion. One issue is whether this is one general condition or separate entities. Another issue is whether sensitization may be the psychobiological mechanism for most or all of these conditions. Finally, is it likely that sustained arousal may facilitate the development of sensitization in some or many neural circuits? In this review, the main emphasis will be on musculoskeletal pain. This is the most frequent and most expensive condition for sickness compensation and disability. The comorbidity of other complaints, however, will also be taken into account.
Asunto(s)
Nivel de Alerta/fisiología , Sensibilidad Química Múltiple/psicología , Enfermedades Musculoesqueléticas/psicología , Dolor/psicología , Pacientes/psicología , Trastornos Somatomorfos/psicología , Estrés Fisiológico/psicología , Adaptación Fisiológica , Adaptación Psicológica , Animales , Cultura , Umbral Diferencial/fisiología , Fatiga/etiología , Fatiga/fisiopatología , Fatiga/psicología , Humanos , Hiperalgesia/etiología , Hiperalgesia/fisiopatología , Sistema Hipotálamo-Hipofisario/fisiopatología , Potenciación a Largo Plazo/fisiología , Modelos Neurológicos , Modelos Psicológicos , Sensibilidad Química Múltiple/fisiopatología , Enfermedades Musculoesqueléticas/etiología , Enfermedades Musculoesqueléticas/fisiopatología , Sistema Musculoesquelético/fisiopatología , Dolor/etiología , Dolor/fisiopatología , Umbral del Dolor/fisiología , Sistema Hipófiso-Suprarrenal/fisiopatología , Células del Asta Posterior/fisiología , Ratas , Trastornos Somatomorfos/etiología , Trastornos Somatomorfos/fisiopatología , Estrés Fisiológico/fisiopatología , Síndrome , Tálamo/fisiopatologíaRESUMEN
The Defense Mechanism Test (DMT) is claimed to identify personnel with a high risk for accidents. A new explanation for why the DMT seems to predict performance when survival depends on split second decisions is proposed. Sixteen right-handed, adult male students were tested with the DMT and with an ERP paradigm (two sine wave tones, presented binaurally). Each subject was tested with a one-stimulus paradigm, and a passive and an active oddball paradigm. Under the passive oddball condition, High defensive subjects differed from Low, having significantly smaller N2 amplitudes (low immediate perception), and significantly larger P3 amplitudes (rely on later associative mechanisms). High defensive subjects seem to have less ability to perceive the environment correctly immediately. This slowness may be fatal when life depends on split second decisions. The fundamental neurophysiological difference may also be the basis for the very complex cognitive and perceptual mechanisms involved in psychological defense mechanisms.
Asunto(s)
Toma de Decisiones/fisiología , Mecanismos de Defensa , Discriminación en Psicología/fisiología , Potenciales Evocados , Adulto , Análisis de Varianza , Electroencefalografía , Humanos , Masculino , Noruega , Sobrevida/fisiología , Sobrevida/psicologíaRESUMEN
STUDY DESIGN: A controlled randomized clinical trial was performed. OBJECTIVE: To investigate the effect of a light mobilization program on the duration of sick leave for patients with subacute low back pain. SUMMARY OF BACKGROUND DATA: Early intervention with information, diagnostics, and light mobilization may be a cost-effective method for returning patients quickly to normal activity. In this experiment, patients were referred to a low back pain clinic and given this simple and systematic program as an outpatient treatment. METHODS: In this study, 457 patients sick-listed 8 to 12 weeks for low back pain, as recorded by the National Insurance Offices, were randomized into two groups: an intervention group (n = 237) and a control group (n = 220). The intervention group was examined at a spine clinic and given information and advice to stay active. The control group was not examined at the clinic, but was treated with conventional primary health care. RESULTS: At 12-month follow-up assessment, 68.4% in the intervention group had returned to full-duty work, as compared with 56.4% in the control group. CONCLUSIONS: Early intervention with examination, information, and recommendations to stay active showed significant effects in reducing sick leave for patients with low back pain.
Asunto(s)
Terapia por Ejercicio , Dolor de la Región Lumbar/rehabilitación , Ausencia por Enfermedad , Adolescente , Adulto , Evaluación de la Discapacidad , Femenino , Estudios de Seguimiento , Humanos , Región Lumbosacra/fisiología , Masculino , Persona de Mediana Edad , Pacientes Ambulatorios , Educación del Paciente como Asunto , Evaluación de Capacidad de Trabajo , Indemnización para TrabajadoresAsunto(s)
Terapia por Ejercicio , Ejercicio Físico , Dolor de la Región Lumbar/rehabilitación , Modalidades de Fisioterapia , Enfermedad Crónica , Terapia por Ejercicio/economía , Humanos , Dolor de la Región Lumbar/psicología , Noruega , Modalidades de Fisioterapia/economía , Autocuidado/economía , Ausencia por Enfermedad/estadística & datos numéricosRESUMEN
Within the Cognitive Activation Theory of Stress (CATS), the stress response occurs whenever there is a discrepancy between what the organism is expecting, and what really exists. It affects the biochemistry of the brain, mobilizes resources, affects performance, and endocrine, vegetative, and immune systems. Initial positive feedback and feed-forward mechanisms are gradually changed by homeostatic mechanisms. Slower reactive hormones such as cortisol seem to dampen the initial response. The time course may depend on psychological mechanisms. Subjects with efficient coping show the fast- and short-lasting catecholamine response, while subjects with high defense mechanisms (related to stimulus expectancies) may show more signs of prolonged activation. Non-coping individuals show a sustained general activation which may develop into somatic disease or illness.
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Estado de Salud , Estrés Psicológico/psicología , Sobrevida/fisiología , Adaptación Psicológica/fisiología , Encéfalo/metabolismo , Catecolaminas/metabolismo , Mecanismos de Defensa , Electroencefalografía , Humanos , Hidrocortisona/sangre , Hidrocortisona/metabolismo , Psiconeuroinmunología , Estrés Psicológico/metabolismo , Factores de TiempoRESUMEN
The aim of this study is to present a complete scoring system for subjective health complaints (SHC) as they are experienced by the lay population. The scoring system records the complaints, and does not map attributions or medical diagnoses. In all, 1,219 subjects (323 men, 896 women) from various occupations were tested with a scoring system, the SHC inventory, previously referred to as the Ursin Health Inventory (UHI). The SHC consists of 29 questions concerning severity and duration of subjective somatic and psychological complaints. The SHC inventory yields scores on single items and a total number of health complaints categorized into five factors: musculoskeletal pain (alpha=0.74), pseudoneurology (alpha=0.73), gastrointestinal problems (alpha=0.62), allergy (alpha=0.58) and flu (alpha=0.67). The SHC inventory is a systematic, easy, and reliable way to score subjective health complaints. The prevalence of these complaints is high, and should be considered before conclusions are reached about new diseases and new attributions of environmental hazards.
Asunto(s)
Evaluación de la Discapacidad , Enfermedades Profesionales/diagnóstico , Psicometría/métodos , Encuestas y Cuestionarios , Adulto , Análisis de Varianza , Análisis Factorial , Femenino , Enfermedades Gastrointestinales/diagnóstico , Enfermedades Gastrointestinales/epidemiología , Humanos , Hipersensibilidad/diagnóstico , Hipersensibilidad/epidemiología , Gripe Humana/diagnóstico , Gripe Humana/epidemiología , Modelos Logísticos , Masculino , Enfermedades Musculoesqueléticas/diagnóstico , Enfermedades Musculoesqueléticas/epidemiología , Noruega/epidemiología , Enfermedades Profesionales/epidemiología , Prevalencia , Trastornos Psicofisiológicos/diagnóstico , Trastornos Psicofisiológicos/epidemiología , Reproducibilidad de los Resultados , Índice de Severidad de la Enfermedad , Distribución por SexoRESUMEN
A condensed test battery (the CODE) based on the Utrecht Coping List (UCL) and part of the Defense Mechanisms Inventory (DMI) has been developed to assess coping and defense in large population studies. It was tested for reliability and validity in students and back pain patients. Principal components factor analysis of the subscales of the UCL and DMI in the student sample revealed two coping clusters: "Instrumental mastery-oriented coping" and "Emotion-focused coping" and two defensive clusters: "Cognitive defense" and "Defensive hostility". "Instrumental mastery-oriented coping" was negatively related to subjective health complaints measured with Ursins Health Inventory (UHI). The back pain patients were clearly different from the students, using less coping and more defensive strategies. They had more subjective health complaints that showed negative correlations with "Instrumental mastery-oriented coping". The CODE is a comprehensive battery that may be valid for large population studies of psychological determinants of muscle pain and other subjective health problems.
Asunto(s)
Adaptación Psicológica , Mecanismos de Defensa , Estado de Salud , Pruebas Psicológicas , Psicometría , Adulto , Dolor de Espalda/psicología , Análisis Factorial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Países Bajos , Reproducibilidad de los ResultadosRESUMEN
The aim of this study was to examine the relationship between psychological defense as measured by the Kragh tachistoscopic Defense Mechanisms Test (DMT), and general arousal properties of the individual as measured with electroencephalogram (EEG). The DMT assesses defense by presenting neutral and threatening pictures with very short exposure times. EEG characteristics were measured in the 8-12 Hz EEG frequency band during DMT testing. Twenty-one male subjects participated in the study. All were US Air Force personnel on active duty. Personnel with high defense mechanisms, defined in this connection as slow perception of the threat, tended to have higher cortical arousal after Stimulus exposure than the subjects with low defense mechanisms. The differences occurred mainly with new stimulus material without any threatening content. The differences in arousal response to novel stimuli may contribute to an understanding of the relationships between the Kragh DMT test and performance in life-threatening situations.
Asunto(s)
Nivel de Alerta , Mecanismos de Defensa , Electroencefalografía , Personal Militar/psicología , Adulto , Nivel de Alerta/fisiología , Atención/fisiología , Corteza Cerebral/fisiología , Potenciales Evocados Visuales/fisiología , Humanos , Masculino , Persona de Mediana Edad , Reconocimiento Visual de Modelos/fisiología , Defensa Perceptual , Tiempo de Reacción/fisiologíaRESUMEN
Fifteen women with pharmacologically intractable epilepsy were given physical exercise (aerobic dancing with strength training and stretching) for 60 min, twice weekly, for 15 weeks. Seizure frequency was recorded by the patients for 3-7 months before the intervention, during the intervention period, and for 3 months after the intervention. Medication and other known seizure-influencing factors were kept as constant as possible. Self-reported seizure frequency was significantly reduced during the intervention period. The exercise also led to reduced level of subjective health complaints, such as muscle pains, sleep problems, and fatigue. The exercise reduced plasma cholesterol ratio and increased maximum O2 uptake. Because most of the patients were unable to continue the exercise on their own after the intervention period, the exercise effects were not maintained during the follow-up period. The patients were not unwilling to continue the exercise, but it was not sufficient to offer them the possibility of continuing similar types of exercise. We believe that 15 weeks is too short a time to establish a life-style change and that continued physical exercise for these patients requires a well-organized and supportive program, requiring experienced and dedicated instructors.