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Very tight regulations apply to materials used for pharmaceutical packaging and for administering drugs. In this paper, we describe a simple and reliable procedure involving both gas- and liquid-phase extraction steps followed by an analysis step to identify the low-molar-mass materials in commercial-rubber samples. Representative commercial rubbers, that could be used for pharmaceutical packaging, have been selected and cryogenically powdered. Headspace and Soxhlet extractions have been carried out and the key parameters are discussed. The obtained extracts have been analyzed by gas chromatography (GC)-mass spectrometry (MS). More than 100 compounds have been detected and identified. Headspace allowed to extract the more-volatile compounds, whereas Soxhlet extraction recovered less-volatile compounds, but induced a loss of the volatile ones. Thus, both extraction techniques are required to fully characterize the low-molar-mass compounds present in rubber.
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Goma/química , Cromatografía de Gases y Espectrometría de Masas/métodos , Peso Molecular , Embalaje de Productos , SolventesRESUMEN
The activity concentration of (99)Tc in brown seaweed (Fucus vesiculosus and Fucus serratus) and seawater were analysed in samples collected in 1991, 1995 and 2001 at several stations along the Swedish west coast. In addition to these locations, a well-defined site (Särdal, 56.76 degrees N, 12.63 degrees E) was included with (99)Tc activity concentration data in seaweed from 1967 to 2000. Over the years, the major source of (99)Tc in the coastal waters of western Sweden has been the radioactive liquid discharge from the nuclear fuel reprocessing plant in Sellafield (UK) transported via ocean currents in the North Sea. The (99)Tc activity concentration in seaweed at the Särdal site increased from approximately 30 Bq kg(-1) up to 230 Bq kg(-1) (dry weight) between 1997 and 2000 due to the Sellafield EARP (Enhanced Actinide Removal Plant) discharges in 1995-1996, yielding an approximate transport time of 4-5 years between the Irish Sea and the Kattegat. Due to the very sharp gradient in (99)Tc concentration between the Baltic Sea and the North Sea, (99)Tc is presently one of the best transit tracers for the recent ventilation events in the Baltic Sea.
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Radioisótopos de Cesio/análisis , Residuos Radiactivos/análisis , Agua de Mar/análisis , Algas Marinas/metabolismo , Tecnecio/análisis , Contaminantes Radiactivos del Agua/análisis , Monitoreo del Ambiente , Humanos , SueciaRESUMEN
The radon activity concentration in ground water from drilled and dug wells on the horst Söderåsen in Southern Sweden has been determined with two different methods, gamma activity measurements with a germanium HPGe detector and alpha activity measurements with plastic track detectors. The results are consistent. High activity concentration is connected to granite bedrock. Dug wells have low concentrations and no trivial correlation between concentration and depth of the well is found. Large local variations exist. Activity concentrations > 700 Bq/l appear to be associated with leakage from layers of volcanic origin. The concentration from drilled wells is found to be quite constant over a 3 year period but short time variations appear to be significant. Evaporation from the open surface of a normal cooking vessel is slow with an activity gradient delta A/A of about 0.1-0.2 per hour at room temperature whereas even modest heating of water in e.g. a coffee machine is very efficient and reduces the radon activity concentration by > 90% in one process.
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Radón/análisis , Contaminantes Radiactivos del Agua/análisis , Abastecimiento de Agua/análisis , SueciaRESUMEN
During a 10-year period, 1988-1998, surface soil samples have been collected at Blentarp in southern Sweden and analysed for 137Cs from the Chernobyl accident and from the nuclear weapons tests. The distance between the sampling plots on the different sampling occasions has been no more than 3 m. The results show that the depth distribution of 137Cs is very similar for each of the sampling occasions, indicating that the caesium migration at this site is very small. The total activity measured in the soil cores is in agreement with the calculated activity of 137Cs deposited at the site after nuclear weapons tests and the Chernobyl accident, based on air activity concentration and the amount of precipitation. The calculated deposition of 137Cs originating from the bomb tests amounts to 1.41 kBq m-2 for the period 1962-1986, which is in agreement with the activity of nuclear weapons fallout measured in the soil samples (1.60 kBq m-2 as a mean value of the first four years of sampling). The calculated activity of 137Cs of Chernobyl origin was 0.79 kBq m-2, which agrees well with the value of 0.79 kBq m-2 measured in the soil samples in 1988.
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Radioisótopos de Cesio/análisis , Ceniza Radiactiva , Contaminantes Radiactivos del Suelo/análisis , Guerra Nuclear , Liberación de Radiactividad Peligrosa , Lluvia , Suecia , Factores de Tiempo , UcraniaRESUMEN
Neutrinos are elementary particles that carry no electric charge and have little mass. As they interact only weakly with other particles, they can penetrate enormous amounts of matter, and therefore have the potential to directly convey astrophysical information from the edge of the Universe and from deep inside the most cataclysmic high-energy regions. The neutrino's great penetrating power, however, also makes this particle difficult to detect. Underground detectors have observed low-energy neutrinos from the Sun and a nearby supernova, as well as neutrinos generated in the Earth's atmosphere. But the very low fluxes of high-energy neutrinos from cosmic sources can be observed only by much larger, expandable detectors in, for example, deep water or ice. Here we report the detection of upwardly propagating atmospheric neutrinos by the ice-based Antarctic muon and neutrino detector array (AMANDA). These results establish a technology with which to build a kilometre-scale neutrino observatory necessary for astrophysical observations.
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The long-term biokinetics and dosimetry of carbon-14 were studied in nine adults and eight children undergoing carbon-14 urea breath test for Helicobacter pylori (HP) infection. The elimination of 14C via exhaled air and urine was measured with the liquid scintillation counting technique and with accelerator mass spectrometry. After the subjects had been given 110 kBq 14C-urea (children: 55 kBq) orally, samples of exhaled air were taken up to 180 days after administration and samples of urine were collected up to 40 days. Sixteen of the subjects were found to be HP-negative. In these subjects a total of 91.1%+/-3.9% (mean of adults and children +/- standard error of the mean) of the administered 14C activity was recovered. The majority of the administered activity, 88.3%+/-6.2% in adults and 87.7%+/-5.0% in children, was excreted via the urine within 72 h after administration. A smaller fraction was exhaled. In adults 4.6%+/-0.6% of the activity was exhaled within 20 days and in children 2.6%+/-0.3%. Uncertainties in the biokinetic results are mainly due to assumptions concerning endogenous CO2 production and urinary excretion rate and are estimated to be less than 30%. The absorbed dose to various organs and the effective dose were calculated using the ICRP model for urea and CO2. The urinary bladder received the highest absorbed dose: in adults, 0.15+/-0.01 mGy/MBq and in children of various ages (7-14 years), 0.14-0.36 mGy/MBq. The findings indicate that an investigation with 14C-urea gives an effective dose to adults of 2.1+/-0.1 microSv (for 110 kBq) and to children of 0.9-2.5 microSv (for 55 kBq). From a radiation protection point of view, there is thus no reason for restrictions on even repeated screening investigations with 14C-urea in whole families, including children.
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Pruebas Respiratorias , Infecciones por Helicobacter/diagnóstico , Helicobacter pylori/aislamiento & purificación , Adolescente , Adulto , Anciano , Radioisótopos de Carbono/farmacocinética , Niño , Humanos , Persona de Mediana Edad , Modelos Biológicos , Dosis de Radiación , Protección Radiológica , Urea/farmacocinéticaRESUMEN
We discuss recent measurements of the wavelength-dependent absorption coefficients in deep South Pole ice. The method uses transit-time distributions of pulses from a variable-frequency laser sent between emitters and receivers embedded in the ice. At depths of 800-1000 m scattering is dominated by residual air bubbles, whereas absorption occurs both in ice itself and in insoluble impurities. The absorption coefficient increases approximately exponentially with wavelength in the measured interval 410-610 nm. At the shortest wavelength our value is approximately a factor 20 below previous values obtained for laboratory ice and lake ice; with increasing wavelength the discrepancy with previous measurements decreases. At ~415 to ~500 nm the experimental uncertainties are small enough for us to resolve an extrinsic contribution to absorption in ice: submicrometer dust particles contribute by an amount that increases with depth and corresponds well with the expected increase seen near the Last Glacial Maximum in Vostok and Dome C ice cores. The laser pulse method allows remote mapping of gross structure in dust concentration as a function of depth in glacial ice.
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OBJECTIVE: To compare the heat characteristics of the microwave antennae, the absorbed energy in the target volume and the cooling capacity of the catheters of three common devices for transurethral microwave thermotherapy (TUMT), i.e. the Prostcare, Prostatron and ProstaLund. MATERIALS AND METHODS: The microwave emission from the respective catheters or antennae was measured in a tissue-equivalent 'phantom' prostate. From these measurements the distribution of absorbed energy from the respective catheters and antennae was calculated from the characteristics of the phantom, the absorbed energy and the temperature difference before and after heating. The cooling capacity of the different catheters were measured by submerging each catheter in a thermally isolated water bath at a known temperature and determining the cooling of the water bath caused by the catheter. RESULTS: The design of the microwave antenna influenced the heating profile significantly. The energy absorbed by the prostate model varied among the devices, but was between 13 and 21% of the stated applied energy. The cooling capacity also varied, being least in the Prostcare and greatest in the ProstaLund catheters. CONCLUSIONS: Users of TUMT should be aware of possible back-heating along the catheter, as this limits the microwave power that can be used safely. Furthermore, the 'treatment energy', which is commonly used as an indicator to describe the intensity of TUMT treatments, is ambiguous and not stringent, in that the microwave energy absorbed in the prostate is only a small fraction of this value.
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Hipertermia Inducida/instrumentación , Microondas/uso terapéutico , Ablación por Catéter , Cateterismo , Calor , Humanos , Masculino , Modelos Anatómicos , Enfermedades de la Próstata/cirugíaRESUMEN
Long-term measurements of 14C in CO2 expired after ingestion of 14C-labelled triolein were performed using accelerator mass spectrometry (AMS). About 30% of a given amount of 14C-labelled triolein was catabolized rapidly, while the remaining 70% had a very slow turnover. The study shows the potential of the AMS technique for the study of the long-term biokinetics of 14C-labelled pharmaceuticals. The AMS technique allows the administered activity to be reduced by several orders of magnitude without compromising the study. It may also allow studies of rare drug metabolites.
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Dióxido de Carbono/análisis , Radioisótopos de Carbono , Grasas de la Dieta , Metabolismo de los Lípidos , Trioleína/metabolismo , Adulto , Humanos , Masculino , Espectrometría de Masas/métodos , Persona de Mediana Edad , Factores de TiempoRESUMEN
The optical properties of the ice at the geographical South Pole have been investigated at depths between 0.8 and 1 kilometer. The absorption and scattering lengths of visible light ( approximately 515 nanometers) have been measured in situ with the use of the laser calibration setup of the Antarctic Muon and Neutrino Detector Array (AMANDA) neutrino detector. The ice is intrinsically extremely transparent. The measured absorption length is 59 +/- 3 meters, comparable with the quality of the ultrapure water used in the Irvine-Michigan-Brookhaven and Kamiokande proton-decay and neutrino experiments and more than twice as long as the best value reported for laboratory ice. Because of a residual density of air bubbles at these depths, the trajectories of photons in the medium are randomized. If the bubbles are assumed to be smooth and spherical, the average distance between collisions at a depth of 1 kilometer is about 25 centimeters. The measured inverse scattering length on bubbles decreases linearly with increasing depth in the volume of ice investigated.
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The activity concentrations of radionuclides (60Co, 54Mn, 137Cs, 40K) in whole plants of Fucus vesiculosus of different ages, and also in tissues of different ages from the same plants were investigated in the vicinity of the Barsebäck nuclear power plant in southern Sweden. Activity concentration differed between the tissues of different age of the plants, depending on the radionuclide as well as the time of year. The highest concentrations of 60Co and 54Mn were measured in the older parts of the plants in spring and summer, while the activity concentrations of 137Cs and 40K were highest in receptacles and new vegetative fronds. The discharge of radionuclides from the nuclear power plant was reflected in the measured activity concentration in the algae. For 60Co, the response seemed to be smoothed out when considering the whole plant, while the new vegetative tissue better reflected the discharge during the autumn. Thus, it is important to have knowledge about the autecology of the organism when it is used as an indicator for radionuclides.
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Some patients with hearing impairment cannot use conventional hearing aids. One solution for these patients is the use of bone conduction hearing aids; however, this kind of equipment is associated with several problems related to the necessity for a good contact between the transducer and the temporal bone. Direct bone contact would be an ideal solution provided that safe and reaction-free skin penetration and a safe and permanent bone anchorage could be achieved. Brånemark et al have developed a procedure to furnish edentulous patients with fixed bridges using titanium implants. This report is focused on the clinical status of the soft tissue adjacent to the 67 skin-penetrating devices in 60 patients. The patients have been followed between 3 and 96 months on 313 occasions, which represents a total observation time of 1515 months of clinical performance. Only one implant was extracted due to adverse skin reaction, giving a failure rate of 0.07% per month. This is comparable with the failure rate of cardiac pacemakers 0.02-0.04% per month).
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Conducción Ósea , Audífonos/efectos adversos , Prótesis e Implantes/efectos adversos , Titanio/efectos adversos , Materiales Biocompatibles , Femenino , Humanos , MasculinoRESUMEN
Guinea pigs were exposed to noise in various workshops at a shipyard. The equivalent sound level ranged from 87 to 90 dB(A) and the exposure time was 30 days of 8 hours. The numbers of lost outer hair cells were greater than in control animals, thus establishing a relation between the number of lost hair cells and the total noise dose. A comparison between the results obtained here and results obtained in laboratory experiments shows that although many physical sound parameters may be identical, the effect on the hair cells can be quite different. In particular, the total noise dose is not a parameter which can be directly related to hair cell loss. The most probable explanation for the difference in damage between the laboratory and workshop animals seems to be the rest periods of 16 hours between each of the 8-hour exposure periods.
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Células Ciliadas Auditivas/patología , Ruido en el Ambiente de Trabajo/efectos adversos , Ruido/efectos adversos , Animales , Supervivencia Celular , Femenino , Cobayas , Factores de TiempoAsunto(s)
Oído Externo , Prótesis e Implantes , Fenómenos Fisiológicos de la Piel , Titanio , Adolescente , Adulto , Anciano , Niño , Femenino , Humanos , Masculino , Apófisis Mastoides , Persona de Mediana Edad , Cicatrización de HeridasRESUMEN
Guinea pigs were exposed to noise in various workshops at a shipyard. The equivalent sound level ranged from 87 to 90 dB(A) and the exposure time was 30 days of 8 hours. The numbers of lost outer hair cells were greater than in control animals, thus establishing a relation between the number of lost hair cells and the total noise dose. A comparison between the results obtained here and results obtained in laboratory experiments shows that although many physical sound parameters may be identical, the effect on the hair cells can be quite different. In particular, the total noise dose is not a parameter which can be directly related to hair cell loss. The most probable explanation for the difference in damage between the laboratory and workshop animals seems to be the rest periods of 16 hours between each of the 8-hour exposure periods.
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The response of the perilymphatic fluid to complex pressure waves, composed of low-frequency sine waves superimposed on square-wave pressure pulses of varying amplitude was studied. In cats with a patent cochlear aqueduct a pronounced positive pressure change could be induced in the perilymphatic fluid when complex pressure waves were used. The time constants associated with the stabilization of the perilymphatic pressure after the application of pressure complexes were longer than those associated with square-wave pulses alone. The results indicate that the functional patency of the cochlear aqueduct could be influenced by the transmission of complex pressure waves. The results also indicate that when trying to influence the inner ear hydrodynamic balance in patients with Meniere's disease, the effect of complex pressure waves is far superior to the effect of square-wave pressure pulses in patients with an open cochlear aqueduct.
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Cóclea/fisiología , Acueducto Coclear/fisiología , Líquidos Laberínticos/fisiología , Perilinfa/fisiología , Animales , Gatos , Enfermedad de Meniere/fisiopatología , Presión , Factores de TiempoRESUMEN
The inner ear hydrodynamics have been studied in a series of experiments on cats. A detailed analysis has been made of the perilymphatic pressure response to square wave pressure pulses applied to the ear canal and middle ear. It was found that the initial pressure response was followed by a rebound pressure response of the opposite phase. It was also found that in most cases each phase of the pressure response could be expressed in terms of two time constants. When the cochlear aqueduct was patent, the perilymphatic pressure response showed almost equal positive and negative pressure changes. However, when the cochlear aqueduct was surgically blocked, the perilymphatic pressure response consisted almost exclusively of the first phase of the response, while the rebound phase disappeared almost completely. The possibility of influencing the inner ear fluid balance in Meniere's disease by external pressure changes is discussed in the light of the present experimental results.
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Líquidos Laberínticos/fisiología , Perilinfa/fisiología , Animales , Gatos , Acueducto Coclear/fisiología , Oído Medio/fisiología , Enfermedad de Meniere/fisiopatología , Presión , Factores de TiempoRESUMEN
The hearing threshold levels of a small group of shipyard workers having differing degrees of hearing impairment were measured five times using the following audiometric techniques: fixed-tone Békésy audiometry with MX 41/AR cushions, fixed-tone Békésy audiometry with an ear speculum, and sweep-frequency Békésy audiometry with an ear speculum. From these data the mean standard deviations of the hearing threshold levels for the frequencies 0.5, 1, 2, 3, 4, 5, 6, 7 and 8 kHz were calculated, thus giving a measure of the accuracy of each method. The hearing threshold levels obtained by the three methods are compared, and the merits of data handling, expressing hearing threshold levels in pascals rather than decibels, are also discussed.
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Audiometría de Tonos Puros/métodos , Audiometría/métodos , Audiometría de Tonos Puros/instrumentación , Umbral Auditivo , Trastornos de la Audición/diagnóstico , HumanosRESUMEN
The function of the maxillary ostia (phi 0.22-4.7 mm) has been evaluated in experiments on a nose-sinus model with variable sinusal volumes. A piston-pump producing to-and-fro volumes of 467 cm3 of air per revolution was used at a speed of 10 and 20 revolutions per minute (rpm). Three different techniques were used: simultaneous pressure recording in the sinus and the nose (Method I); simultaneous recording of the differential pressure between nose and sinus and the air-flow through the ostium (Method II); recording of the pressure rise inside the sinus upon the application of a constant artificial air-flow of 16,7 cm3 . s-1 or 2.0 cm3 . s-1 (Method III). All variables were recorded on an ink-jet recorder and onto tape when using methods I and II for later analysis on an x-y recorder. A pressure relationship of 1 : 1 was found between nose and sinus, independently of ostial diameters, sinusal volumes and piston-pump rates. The first method did not permit an isolated determination of the ostial function as the pressure values recorded are affected by ostial diameters, sinusal volumes and piston-pump rates. The pressure-flow relationship recorded with the second method was found to be dependent only on the ostial diameters. Hysteresis was observed at ostial diameters less than or equal to 1.63 mm. This is due to ostial diameter, sinusal volume and the rate of the nasal pressure changes. This method is suitable for an isolated determination of the ostial resistance, from which the equivalent ostial diameter can be calculated. With the third method using static air-flows and pressures the results are independent of the sinusal volume. This method is suitable for estimation of the ostial airway resistance and the equivalent ostial diameter. A striking similarity was observed between the results obtained with the last two methods in estimating equivalent ostial diameters.
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Cateterismo/instrumentación , Seno Maxilar/fisiología , Modelos Biológicos , Nariz/fisiología , Resistencia de las Vías Respiratorias , Cateterismo/métodos , Humanos , Seno Maxilar/anatomía & histología , Modelos Anatómicos , Presión , Ventilación PulmonarRESUMEN
The hearing thresholds of a total of 58 workers aged 20 to 65 years were measured annually over a period of 4 years using Békésy sweep-frequency audiometry. Using these data, accurate values of the yearly rate of change of hearing threshold level were calculated. The rate of change of hearing threshold level due to presbyacusis was obtained from several data sets, and the rate of change of hearing threshold level due to noise was calculated. When the average hearing threshold level over the frequency range 2-8 kHz was considered, it was found to be possible to establish a significant rate of threshold shift caused by exposure to noise for yearly changes as small as approximately 2 dB. In the cases investigated about 30% of the ears showed a significant deterioration in hearing ability due to noise. When comparing the permanent threshold shift caused by noise in groups of younger and older workers, it was found that the younger workers exhibited less threshold shift than expected, whereas the older workers showed a greater threshold shift than expected.