1.
J Med Chem
; 48(7): 2258-61, 2005 Apr 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15801816
RESUMEN
A series of fluoroglycosylated fluoroindolocarbazoles was examined with respect to their topoisomerase I activity, cytotoxicity, and selectivity. The lead clinical candidate from this series, BMS-250749, displays broad spectrum antitumor activity superior to CPT-11 against some preclinical xenograft models, including curative antitumor activity against Lewis lung carcinoma.