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Purpose@#This study was conducted to develop a measurement scale for the care burden experienced by families of elderly individuals in nursing facilities. @*Methods@#We developed a preliminary tool based on a broad range of past studies, including experiences of care burden for the families of the elderly in nursing facilities. This tool is anchored on Pearlin’s (1990) construct of the stress process model. Data were collected from 208 families of elderly individuals in nursing facilities, and the construct validity and reliability of the preliminary scale were verified. @*Results@#We developed a questionnaire consisting of a four-point Likert-type scale in a self-report form with 30 items divided into 4 factors. The factors were named 'Social burden', 'Economic burden', 'Psychological burden', and 'Physical burden'. The Cronbach’s ⍺ of the total items was .94, and the factors ranged from .65 to .87. @*Conclusion@#The study results will help evaluate the level of caregiving burden for families of the elderly in nursing facilities. Therefore, it is expected to be used in future research on nursing interventions aimed at improving the understanding of caregiving burden and reducing the caregiving burden of elderly family members in nursing facilities.
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Purpose@#This study investigated the effects of nursing unit managers' authentic, transformational, and transactional leadership styles on positive psychological capital and turnover intention in advanced beginner-stage nurses (ABNs). @*Methods@#The study included 157 nurses with clinical experience ranging form more than one year to less than 3 years in three general hospitals. Data analysis was conducted using the SPSS/WINdows software version 26.0. @*Results@#Authentic, transformational, and transactional leadership styles of nursing unit managers increased the positive psychological capital of ABNs, thereby lowering their turnover intention. Additionally, the turnover intention of ABNs was negatively correlated with the authentic, transformational, and transactional leadership styles of a nursing unit manager and positive psychological capital. Positive psychological capital showed a mediating effect in the relationship between authentic, transformational, and transactional leadership styles of nursing unit manager and turnover intention of ABNs. @*Conclusion@#To reduce ABNs turnover, medical institutions and nursing organizations should focus on enhancing nursing unit managers’ transformational and authentic leadership styles. Moreover, as transactional leadership has been found to decrease the turnover intention among ABNs, nursing unit managers should carefully consider their responsibilities and resources allocation to provide conditional compensation support to nurses.
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Purpose@#The objectives of this study were to categorize the conflict management types of preceptor nurses and determine the effects of these types on preceptors’ role perception and core competencies. @*Methods@#Data was collected from 192 preceptor nurses with at least two years experiences in general hospitals, from July 1 to July 31, 2022. Conflict management type, preceptor role perception, and core competency were investigated using structured instruments. The data was analyzed using K-means cluster analysis, Independent samples t-test, One-way ANOVA with Scheffé‘s test, and multiple regression analysis. @*Results@#The conflict management types were categorized into four types; comprehensive type (cluster 1), integrating, obliging, compromising type (cluster 2), undifferentiated type (cluster 3) and obliging, avoiding type (cluster 4). The effect of conflict management types on preceptors’ role recognition occurred in the following order of cluster 2 (integrating/obliging/compromising type), cluster 1 (comprehensive type), and cluster 4 (obliging/avoiding type). Next, cluster 1 (comprehensive type), cluster 2 (integrating/obliging/compromising type), and cluster 4 (obliging/avoiding type) were shown in the order of the impact on the core competencies of the preceptor. @*Conclusion@#When preceptor nurses use a mixture of various attributes of conflict management evenly, they have been shown to demonstrate effective preceptor role recognition and core competencies. Therefore, it is proposed that future development of conflict management training programs for preceptor nurses should begin with identifying their conflict management type, followed by creating a program that addresses any deficiencies.
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Purpose@#This study investigated the impact of nurse practice environment and organizational justice on nurses’job satisfaction. @*Methods@#We identified the factors between nursing work environment and organizational justice to job satisfaction for 189 nurses working at a general hospital in city C. Data were collected from June 1st to 15th, 2023, and analyzed using descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficients, and multiple stepwise regression, using IBM/SPSS 27.0 for the Windows program. @*Results@#The mean job satisfaction was 3.24±0.55 points on a 5-point scale. Multiple stepwise regression revealed that the factors affecting nurses’job satisfaction included nursing foundations for quality of care (β=.26, p=.005), staffing and resource adequacy (β=.40, p<.001), collegial nurse-physician relations (β=-.24, p=.007), and distributive justice(β =.27, p<.001).These variables explained 55.0% of job satisfaction. @*Conclusion@#The research findings indicate that higher job satisfaction is associated with a better nurse practice environment and positive perceptions of organization justice. These findings indicate that it is necessary to enhance the nurse practice environment and improve organizational justice to enhance job satisfaction among nurses.
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Recurrent spillovers of - and {beta}-coronaviruses (CoV) such as acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome (MERS)-CoV, SARS-CoV-2, and possibly human CoV (NL63, 229E, OC43, and HKU1) have caused serious morbidity and mortality worldwide. Six receptor binding domains (RBDs) derived from - and {beta}-CoV that are considered to have originated from animals and cross-infected humans were linked to proliferating cell nuclear antigen (PCNA) heterotrimeric subunits, PCNA1, PCNA2, and PCNA3. These were used to form a scaffold-based mosaic multivalent antigen, 6RBD-np. Electron microscopic and atomic force microscopic images show a ring-shaped disk with six protruding RBDs, like jewels in a crown, with a size of 40 nm. Prime-boost immunizations with 6RBD-np in BALB/c mice elicited strong, dose-dependent antibody responses. In human angiotensin converting enzyme 2-transgenic mice, the same immunization induced full-protection against SARS-CoV-2 wild type and Delta challenges, resulting in a 100% survival rate. The mosaic 6RBD-np provides a potential platform for developing a pan-CoV vaccine against newly emerging SARS-CoV-2 variants and future CoV spillovers. SignificanceDespite the arsenal of COVID-19 vaccines, hospitalization and mortality associated with SARS-CoV-2 (acute respiratory syndrome coronavirus 2) variants remain high. There is an urgent need to develop next-generation COVID vaccines that provide broad protection against diseases by current and newly emerging SARS-CoV-2 variants. In this study, six receptor binding domains (RBDs) derived from - and {beta}-CoV were linked to proliferating cell nuclear antigen (PCNA) heterotrimeric scaffolds. They assemble to create a stable mosaic multivalent nanoparticle, 6RBD-np, displaying a ring-shaped disk with six protruding antigens. The prime-boost immunization in BALB/c and human angiotensin converting enzyme 2-transgenic mice with the 6RBD-np elicited strong, dose-dependent antibody responses and induced full-protection against both the SARS-CoV-2 wild type (WT) and Delta challenges. This study provides proof-of-concept that the mosaic 6RBD-np induces 100% protection against SARS-CoV-2 WT and Delta. It provides the potential of co-displaying heterologous antigens for novel vaccine designs, which can be deployed countering future pandemics.
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BACKGROUND/OBJECTIVES@#Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal production of estrogen and progesterone, leading to PMS symptoms. Thus, we judged that the inhibition of prolactin hypersecretion could mitigate PMS symptoms.MATERIALS/METHODS: Hordeum vulgare L. extract (HVE), Chrysanthemum zawadskii var. latilobum extract (CZE), and Lomens-P0 the mixture of these extracts were tested in subsequent experiments. The effect of extracts on prolactin secretion at the in vitro level was measured in GH3 cells. Nitric oxide and pro-inflammatory mediator expression were measured in RAW 264.7 cells to confirm the anti-inflammatory effect. Also, the hyperprolactinemic Institute for Cancer Research (ICR) mice model was used to measure extract effects on prolactin and hormone secretion and uterine inflammation. @*RESULTS@#Anti-inflammatory effects of and prolactin secretion suppress by HVE and CZE were confirmed through in vitro experiments (P < 0.05). Treatment with Lomens-P0 inhibited prolactin secretion (P < 0.05) and restored normal sex hormone secretion in the hyperprolactinemia mice model. In addition, extracts significantly inhibited the expression of pro-inflammatory biomarkers, including interleukin-1β, and -6, tumor necrosis factor-α, inducible nitric oxide synthase, and cyclooxygenase-2 (P < 0.01). We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. The Lomens-P0, which includes tricin and chlorogenic acid, is expected to be effective in improving PMS symptoms in the human body. @*CONCLUSIONS@#The Lomens-P0 suppressed the prolactin secretion in hyperprolactinemia mice, normalized the sex hormone imbalance, and significantly suppressed the expression of inflammatory markers in uterine tissue. This study suggests that Lomens-P0 may have the potential to prevent or remedy materials to PMS symptoms.
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Background@#This study explored the clinical variables related to public workers' stress and anxiety regarding the viral epidemic, and the mediating effect of resilience on the relationship between their depression and anxiety in response to coronavirus disease 2019 (COVID-19) pandemic. @*Methods@#A total of 938 public workers answered anonymous questionnaires in May 2020.The survey included rating scales such as the Stress and Anxiety to Viral Epidemics-9 (SAVE-9), Patients Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Connor-Davidson Resilience Scale 2 items (CD-RISC 2), and subjects also answered whether they were employed in COVID-19 related fields. @*Results@#Married, female, junior, public workers reported a higher level of stress and anxiety in response to the viral epidemic. Furthermore, high levels of stress and anxiety toward the epidemic are defined by high PHQ-9, high GAD-7, and low CD-RISC 2 scores. It could also be seen that resilience mediated the effect of depression in public workers and their stress and anxiety levels toward the epidemic. @*Conclusion@#It is important to reduce the psychological burden of public workers and manage their mental health to help them cope with the epidemic wisely and efficiently. Among many mental health factors, psychological resilience represents an essential target for psychological intervention among public workers.
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Background@#This study explored the clinical variables related to public workers' stress and anxiety regarding the viral epidemic, and the mediating effect of resilience on the relationship between their depression and anxiety in response to coronavirus disease 2019 (COVID-19) pandemic. @*Methods@#A total of 938 public workers answered anonymous questionnaires in May 2020.The survey included rating scales such as the Stress and Anxiety to Viral Epidemics-9 (SAVE-9), Patients Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Connor-Davidson Resilience Scale 2 items (CD-RISC 2), and subjects also answered whether they were employed in COVID-19 related fields. @*Results@#Married, female, junior, public workers reported a higher level of stress and anxiety in response to the viral epidemic. Furthermore, high levels of stress and anxiety toward the epidemic are defined by high PHQ-9, high GAD-7, and low CD-RISC 2 scores. It could also be seen that resilience mediated the effect of depression in public workers and their stress and anxiety levels toward the epidemic. @*Conclusion@#It is important to reduce the psychological burden of public workers and manage their mental health to help them cope with the epidemic wisely and efficiently. Among many mental health factors, psychological resilience represents an essential target for psychological intervention among public workers.
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Purpose@#Cancer-related fatigue (CRF) is an important health concern among breast cancer survivors. However, CRF is apt to be dismissed as a minor discomfort by medical professionals. This study aimed to understand the experience of CRF in breast cancer survivors. @*Methods@#We conducted a qualitative study using in-depth interviews and thematic analysis. The 14 participants were over the age of 40, complained of fatigue, and had been battling breast cancer for at least eight months to up to 16 years. @*Results@#The analysis revealed four themes: traces of fighting cancer, inseparable part of the self, difficulty in daily life, and the body’s signals for care.Chronic fatigue initially disrupted the daily lives of the participants. As time passed, fatigue made it difficult for patients to fulfill their roles within their families, and gradually alienated friends and neighbors. Nevertheless, they tried to overcome the symptoms of fatigue by responding sensitively to the warning signs or changes in their bodies. @*Conclusion@#Breast cancer survivors often worry about relapse due to persistent fatigue after treatment completion. Therefore, the results of this study may be useful in developing strategies tailored for managing CRF using a multifaceted approach.
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Purpose@#Many home care treatments can be used to promote the health and longevity of dental implants; however, few studies are available to support the concept that selfperformed oral hygiene behaviors are an essential tool for improving and maintaining oral health. We investigated age-stratified associations between dental health behaviors related to tooth brushing (TB) and oral hygiene product use in Korean adults with implants. @*Methods@#A total of 1,911 subjects over 19 years of age who had 1 or more implants and who participated in the 2013 to 2015 Korea National Health and Nutrition Examination Survey were reviewed. Periodontal status was assessed using Community Periodontal Index (CPI) scores, and periodontitis was defined as a CPI greater than or equal to 3. The complex sampling design of the survey was utilized to obtain the variance and individual weight of each analyzed factor. A high CPI was the outcome variable, and the main explanatory variables were oral hygiene behaviors, such as TB, dental floss (DF), interproximal brushing, and mouth rinsing. @*Results@#Almost all individuals with a lower CPI brushed their teeth twice or more per day, in contrast to those with a higher CPI, and were likely to use DF. The adjusted odds ratio of not using DF for a higher CPI was 1.83 (95% confidence interval, 1.35–2.49). @*Conclusions@#TB was implemented more than twice a day by patients with good oral health, and the combination of TB and DF significantly reduced the prevalence of a higher CPI. Selfperformed oral hygiene practices combining TB and DF were significantly related to a low prevalence of periodontitis in implant patients.
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OBJECTIVES@#Galla chinensis inhibited the adherence of planktonic oral bacteria and acid production by cariogenic bacteria. However, little is known about the relevant conditions of Galla Chinensis extract (GCE) exposure time and concentration and the effect of GCE on the structural and functional activity of cariogenic bacteria. The antibacterial effects of natural G. Chinensis extract on S. mutans , S. sanguinis, and S. oralis biofilms were evaluated in vitro.@*METHODS@#Biofilms formed on glass surfaces were treated with different concentrations of GCE at different exposure times. The effects were assessed by examining the bactericidal activity, acidogenesis, minimum inhibitory concentration, and morphology.@*RESULTS@#There was a statistically significant difference in the bacterial growth inhibition depending on the concentration of the GCE, with bacterial growth being inhibited as the concentration of GCE increased. A concentration of 1.0 mg/ml GCE had similar bactericidal effects against S. mutans and S. oralis biofilms to those produced by 2.0 mg/ml CHX. In the 1.0 mg/ml GCE group, incomplete septa were also observed in the outline of the cell wall, together with disruption of the cell membrane. In addition, there was also a slight exudation of the intracellular content from the bacteria in the 1.0 mg/ml GCE and 2 mg/ml CHX groups.@*CONCLUSIONS@#These results indicate that GCE inhibits the growth of S. mutans, S. sanguinis, and S. oralis with increasing concentrations. It alters the microstructure of S. mutans biofilms. These results suggest that GCE might be a useful anti-bacterial agent for preventing dental caries.
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Purpose@#Many home care treatments can be used to promote the health and longevity of dental implants; however, few studies are available to support the concept that selfperformed oral hygiene behaviors are an essential tool for improving and maintaining oral health. We investigated age-stratified associations between dental health behaviors related to tooth brushing (TB) and oral hygiene product use in Korean adults with implants. @*Methods@#A total of 1,911 subjects over 19 years of age who had 1 or more implants and who participated in the 2013 to 2015 Korea National Health and Nutrition Examination Survey were reviewed. Periodontal status was assessed using Community Periodontal Index (CPI) scores, and periodontitis was defined as a CPI greater than or equal to 3. The complex sampling design of the survey was utilized to obtain the variance and individual weight of each analyzed factor. A high CPI was the outcome variable, and the main explanatory variables were oral hygiene behaviors, such as TB, dental floss (DF), interproximal brushing, and mouth rinsing. @*Results@#Almost all individuals with a lower CPI brushed their teeth twice or more per day, in contrast to those with a higher CPI, and were likely to use DF. The adjusted odds ratio of not using DF for a higher CPI was 1.83 (95% confidence interval, 1.35–2.49). @*Conclusions@#TB was implemented more than twice a day by patients with good oral health, and the combination of TB and DF significantly reduced the prevalence of a higher CPI. Selfperformed oral hygiene practices combining TB and DF were significantly related to a low prevalence of periodontitis in implant patients.
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Purpose@#Cancer-related fatigue (CRF) is an important health concern among breast cancer survivors. However, CRF is apt to be dismissed as a minor discomfort by medical professionals. This study aimed to understand the experience of CRF in breast cancer survivors. @*Methods@#We conducted a qualitative study using in-depth interviews and thematic analysis. The 14 participants were over the age of 40, complained of fatigue, and had been battling breast cancer for at least eight months to up to 16 years. @*Results@#The analysis revealed four themes: traces of fighting cancer, inseparable part of the self, difficulty in daily life, and the body’s signals for care.Chronic fatigue initially disrupted the daily lives of the participants. As time passed, fatigue made it difficult for patients to fulfill their roles within their families, and gradually alienated friends and neighbors. Nevertheless, they tried to overcome the symptoms of fatigue by responding sensitively to the warning signs or changes in their bodies. @*Conclusion@#Breast cancer survivors often worry about relapse due to persistent fatigue after treatment completion. Therefore, the results of this study may be useful in developing strategies tailored for managing CRF using a multifaceted approach.
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BACKGROUND: Dementia is a condition in which a person who has been living a normal life suffers from various cognitive impairments in memory, words, and judgment that considerably disrupt daily life. The oral care ability and subjective oral status of elderly individuals with dementia are lower than those of a healthy person. The oral health care of individuals admitted to nursing homes inevitably falls to nursing assistants and nursing care staff. This study aimed to investigate the need for oral health management items of and to provide basic direction for the future of the Dementia National Responsibility System. METHODS: Elders aged 65 years and over were selected from a comprehensive welfare center. A total of 155 questionnaires were analyzed. The questionnaire consisted of 15 items about general status, 9 items about recognition of the Dementia National Responsibility System, 5 items of the subjective recognition of oral health, and 6 items of the correlation between oral health and dementia. RESULTS: Among our subjects, 71.0% answered that they did not know about the Dementia National Responsibility System, 78.7% answered that they think they need the system, and 81.9% think that they should add dental health items to the Dementia National Responsibility System. The response to the need for dementia national responsibility, oral health items in the Dementia National Responsibility System, and oral specialists all showed scores of >4 points. The need for the Dementia National Responsibility System, oral health items, and specialists were found. CONCLUSION: It is necessary to include oral health care items in the Dementia National Responsibility System so that elderly individuals with dementia can receive the needed oral health care.
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Anciano , Humanos , Accidentes por Caídas , Trastornos del Conocimiento , Demencia , Atención Odontológica , Juicio , Memoria , Enfermería , Atención de Enfermería , Casas de Salud , Salud Bucal , EspecializaciónRESUMEN
BACKGROUND: Erosion is a gradual process that occurs fairly quickly, and the full extent of the erosive effects of acidic beverages is not yet clear. The present study aimed to determine the differences in the erosive potentials among four naturally acidic fruit nectars within the same range of titratable acidity and to determine the influence of the components of organic acids on tooth erosion. METHODS: Diluted fruit nectars (mandarin 1:1.1, orange 1:1.7, lemon 1:15, grapefruit 1:20) with the same range of titratable acidity (7.9 ml) and their corresponding organic acids (0.05%, 0.1%, 0.3%, and 0.5% citric acid, malic acid, and a citric and malic acid mixture [pH 2.8], respectively) were used. Specimens were placed in conical tubes with 50 ml of each of the test solutions for 1 hour. A microhardness test and scanning electron microscopy were used to measure enamel erosion. Acid separation was carried out using high-performance liquid chromatography to analyze the composition of each test solution. RESULTS: Similar decreases in the Vickers hardness number (VHN) were observed among the groups treated with the following diluted fruit nectars: diluted mandarin nectar (75.9 ΔVHN), diluted lemon nectar (89.1 ΔVHN), diluted grapefruit nectar (91.7 ΔVHN), and diluted orange nectar (92.5 ΔVHN). No statistically significant differences were found in the enamel surface hardness after erosion (p>0.05). Citric and malic acids were the major organic acids in the test fruits. The lemon and orange groups had the highest malic acid concentrations, and the mandarin group had the lowest malic acid concentration. CONCLUSION: The titratable acidity and the citric and malic acid contents of the fruits could be crucial factors responsible for enamel erosion. Therefore, fruit-based drinks should be regarded as potentially erosive.
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Bebidas , Cromatografía Liquida , Ácido Cítrico , Citrus paradisi , Citrus sinensis , Esmalte Dental , Frutas , Dureza , Técnicas In Vitro , Microscopía , Microscopía Electrónica de Rastreo , Néctar de las Plantas , Erosión de los DientesRESUMEN
BACKGROUND: Edentulism is associated with socioeconomic status, rural residence, and chronic disease, but no studies have investigated edentulism and residence factors together. All information that drives a better understanding of the factors related to edentulism plays an important role in the planning and delivery of appropriate dental services for the elderly by national and oral health professionals. This study was designed to investigate the prevalence of edentulism in adults aged over 60 years in Korea and to examine whether there are differences in dentate status between people living in urban and rural areas after controlling for sociodemographic and other related factors. METHODS: The data for this study were collected from 2013 to 2015 as part of the Korea National Health and Nutrition Examination Survey VI, those individuals aged over 60 years and who had complete datasets were included (5,071). The number of teeth and residence status were categorized into two groups: edentate and dentate (1 or more); urban and rural. Multiple multivariate logistic regression analyses were sequentially applied to assess the association between dentate status and residence status after adjusting for potential confounders. RESULTS: Rural areas, lower household income, and lower education levels were associated with a higher edentate rate. The number of teeth was lower in rural areas than in urban areas. After adjusting for various factors, statistically significant associations were present for women, low household income, low education level, poor perceived health status, and alcohol consumption in participants. CONCLUSION: Elders living in rural areas had poorer oral health than elders living in urban areas. The government will need to provide effective systems for promoting oral health for elders living in rural areas.
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Adulto , Anciano , Femenino , Humanos , Consumo de Bebidas Alcohólicas , Enfermedad Crónica , Conjunto de Datos , Educación , Composición Familiar , Corea (Geográfico) , Modelos Logísticos , Encuestas Nutricionales , Salud Bucal , Prevalencia , Características de la Residencia , Clase Social , Diente , Población UrbanaRESUMEN
PURPOSE: Obesity is risk factor for nonalcoholic fatty liver disease (NAFLD). However, nonobese patients are also increasingly susceptible to NAFLD. The aim of this study was to compare the clinical characteristics of obese and nonobese pediatric patients with NAFLD. METHODS: We retrospectively studied 68 patients who were diagnosed with NAFLD between January 2010 and October 2016 at 10–18 years of age. Body mass index ≥95th percentile for age and sex was defined as obesity. Abdominal ultrasonography and laboratory, anthropometrics measurements were evaluated. RESULTS: Among the 68, 26 (38.2%) were nonobese patients. The ratio of male to female was 5.8:1, and the median age at diagnosis was 13 years (range, 10–17 years). Significant higher triglyceride (223.0 mg/dL vs. 145.9 mg/dL, P=0.047) and total cholesterol levels (211.6 mg/dL vs. 173.2 mg/dL, P=0.011) were shown in nonobese than obese patients. High-density lipoprotein cholesterol level 200mg/dL (HR, 5.6; 95% CI, 1.23–15.31; P=0.038) and abdominal obesity (HR, 2.53; 95% CI, 1.22–4.68; P=0.013) were significant risk factors for NAFLD in nonobese patients. CONCLUSION: Nonobese patients present a substantial proportion of pediatric NAFLD cases. Significant abnormal lipid concentrations were found in nonobese and abdominal obesity was important risk factor for nonobese NAFLD.
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Femenino , Humanos , Masculino , Índice de Masa Corporal , Colesterol , Diagnóstico , Lipoproteínas , Enfermedades Metabólicas , Enfermedad del Hígado Graso no Alcohólico , Obesidad , Obesidad Abdominal , Obesidad Infantil , Estudios Retrospectivos , Factores de Riesgo , Triglicéridos , UltrasonografíaRESUMEN
BACKGROUND: The purpose of this study was to investigate the relationship between sleep patterns and health in Korea, using data from the Korea National Health and Nutrition Examination Survey 2016–2017.METHODS: In total, 12,646 individuals were divided into those who sleep more than 5 hours and less than 5 hours per day during the week. In addition, 512 people who slept less than 5 hours a day on weekdays were further classified into those sleeping on average less than 5 hours a day and those sleeping more than 5 hours a day on weekends.RESULTS: People who slept on average for more than 5 hours on weekdays were taller, had lower body mass index, and lower fasting blood sugar and glycated hemoglobin levels than those who slept less than 5 hours on weekdays. In addition, the percentage of people with osteoporosis, cervical cancer, and depression was lower in the group that slept on average 5 hours or more on weekdays than in the group that slept less than 5 hours on weekdays. Among those who slept on average less than 5 hours a day on weekdays, individuals who slept more than 5 hours a day on weekends were taller and had lower fasting blood glucose and glycated hemoglobin than those who slept less than 5 hours a day on weekends. The prevalence of patients with angina, arthritis, osteoporosis, colon cancer, and depression was higher in the group who slept less than 5 hours a day on weekends.CONCLUSION: There are differences in height, body mass index, fasting blood sugar level and glycated hemoglobin level and in the prevalence of angina, arthritis, osteoporosis, colon cancer, and depression according to weekday and weekend sleep times.
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Adulto , Humanos , Artritis , Glucemia , Estatura , Índice de Masa Corporal , Neoplasias del Colon , Depresión , Ayuno , Hemoglobina Glucada , Corea (Geográfico) , Encuestas Nutricionales , Osteoporosis , Prevalencia , Neoplasias del Cuello UterinoRESUMEN
Spontaneous intracranial hypotension in childhood is rare, and a few cases have been reported as a cause of headache in children. A 9-year-old boy was admitted to our hospital with a 3-day history of new-onset headache that worsened upon standing or walking, and aggravating low back pain. No medical history of injury, connective tissue disorder or migraine was detected. A neurological examination revealed neck stiffness. His initial blood tests suggested acute kidney injury by increased blood urea nitrogen (BUN) and creatinine. Brain computed tomography (CT) and cerebral spinal fluid (CSF) analysis were normal: however, opening pressure was low (< 60 mm H₂O). Magnetic resonance imaging (MRI) of the spine showed a collection of cerebral spinal fluid in the dorsal extradural space throughout the entire thoracic and lumbar spine level. The patient was diagnosed as having spontaneous intracranial hypotension accompanied by acute kidney injury. Magnetic resonance myelography and spinal MRI performed 14 days later did not show any cerebrospinal fluid leak. The headache and back pain were alleviated with strict bed rest and hydration. He remained free of headache and back pain at the 2-month follow-up. Here, we report a case of a 9-year-old boy with spontaneous intracranial hypotension.
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Niño , Humanos , Masculino , Lesión Renal Aguda , Dolor de Espalda , Reposo en Cama , Nitrógeno de la Urea Sanguínea , Encéfalo , Pérdida de Líquido Cefalorraquídeo , Tejido Conectivo , Creatinina , Estudios de Seguimiento , Cefalea , Pruebas Hematológicas , Hipotensión Intracraneal , Dolor de la Región Lumbar , Imagen por Resonancia Magnética , Trastornos Migrañosos , Mielografía , Cuello , Examen Neurológico , Columna Vertebral , CaminataRESUMEN
OBJECTIVES: The purpose of this study was to investigate the combined effects of Galla chinensis extract (GCE) and calcium (CA) on enamel remineralization. The antibacterial effect of G. chinensis on Streptococcus mutans biofilm was also evaluated by examining the bacterial growth, acidogenesis, and morphology of the biofilm in vitro. METHODS: S. mutans biofilm was formed on bovine enamel specimens over a 72-h period and treated for 10 min with 1.0 mol CA, 4,000 ppm aqueous solution of GCE, or a combination of the two (GCE+CA). The enamel specimens were analyzed for enamel surface microhardness after remineralization. We tested the anti-cariogenic effects of GCE based on the inhibition of acid production, antibacterial activity, and morphological changes in S. mutans. The differences between the groups and antibacterial effects were analyzed using one-way analysis of variance. RESULTS: GCE+CA group showed the highest efficacy in enhancing remineralization. The GCE group showed the highest antibacterial activity against S. mutans biofilm. Although the GCE+CA group showed significant antibacterial activity, it was less than that of the GCE group (P < 0.05). Both GCE and GCE+CA groups maintained a pH of approximately 7.0 for 1 h whereas the pH of the control group decreased rapidly from pH 7.3 to pH 6.1. SEM imaging revealed that S. mutans treated with GCE and GCE+CA showed irregular cell wall structure and showed fewer cells in the chain than the typical long chains observed in the control group. CONCLUSIONS: This study found that natural G. chinensis significantly enhances enamel remineralization, and exerts synergistic effects with calcium. It also exerts strong bactericidal activity and inhibits acid production and changes in the microstructure of S. mutans biofilm.