RESUMEN
Acquired Pendular Nystagmus (APN) may cause distressing visual symptoms in patients who are already suffering a severe general disease. Averbuch-Heller et al. conducted the first double-blind controlled study on treatment for APN. They showed that gabapentin substantially reduces pendular nystagmus and significantly increases visual acuity in the majority of patients. We present a patient with APN due to multiple sclerosis who suffered severe oscillopsy and reduction of visual acuity and who substantially benefited from a trial treatment with this agent.
Asunto(s)
Acetatos/uso terapéutico , Aminas , Ácidos Ciclohexanocarboxílicos , Esclerosis Múltiple/complicaciones , Nistagmo Patológico/tratamiento farmacológico , Ácido gamma-Aminobutírico , Administración Oral , Baclofeno/administración & dosificación , Femenino , Gabapentina , Humanos , Persona de Mediana Edad , Nistagmo Patológico/etiología , Resultado del TratamientoRESUMEN
We investigated the effect of 6 commercially available non-steroidal anti-inflammatory drug (NSAID) eye drops on the normal corneal epithelium of rabbits. Each drug was instilled into both eyes of 2 rabbits, 5 times a day, for 5 consecutive days. Two additional corneas of one rabbit, without any treatment, served as control. After treatment, the corneas were excised and processed for scanning electron microscopic evaluation. The epithelial changes induced by the drugs were graded by an empirical score system. All test compounds caused alterations in the cell membranes and surface microvilli, or even exfoliation and necrosis of surface cells. The extent of cell damage appeared to be related to the active ingredient in the eye drops, the pH of the solution, and the constituents of the vehicle, especially the type of preservative used.
Asunto(s)
Antiinflamatorios no Esteroideos/toxicidad , Endotelio Corneal/efectos de los fármacos , Endotelio Corneal/ultraestructura , Animales , Membrana Celular/efectos de los fármacos , Membrana Celular/ultraestructura , Concentración de Iones de Hidrógeno , Microscopía Electrónica de Rastreo , Microvellosidades/efectos de los fármacos , Microvellosidades/ultraestructura , Necrosis , Soluciones Oftálmicas/química , Soluciones Oftálmicas/toxicidad , Conservadores Farmacéuticos/química , Conservadores Farmacéuticos/toxicidad , ConejosRESUMEN
The purpose of this study was to evaluate the efficacy of three screening tests in detecting glaucoma in its early stage: the Tendency Oriented Perimetry (TOP) and Frequency Doubling Perimetry (FDP) visual field tests, and the Glaucoma Diagnostic (GDx) nerve fibre layer analyser. Eighteen patients with glaucoma who showed an early defect on HFA c 24-2 and twenty normals underwent the three tests. TOP showed a sensitivity of 94.4% and a specificity of 75%, FDP showed a sensitivity of 72.2% and a specificity of 100%, and GDx a sensitivity of 77.7% and a specificity of 60%.