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The food industry uses indigo carmine (IC) extensively as a blue colorant to make processed food for young children and the general population more attractive. Given that IC can act as a ligand, this raises concerns about its interactions with essential metal ions in the human body. In view of this interest, in the present investigation, the copper(II)/indigo carmine system was thoroughly investigated in aqueous solution and in the solid state, and the detailed structural characterization of the complexes formed between copper(II) and the ligand was performed using spectroscopic methods, complemented with DFT and TD-DFT calculations. NMR and UV/Vis absorption spectroscopy studies of the ligand in the presence of copper(II) show changes that clearly reveal strong complexation. The results point to the formation of complexes of 1:1, 1:2 and 2:1 Cu(II)/IC stoichiometry in aqueous solution, favored in the pH range 6-10 and stable over time. DFT calculations indicate that the coordination of the ligand to the metal occurs through the adjacent carbonyl and amine groups and that the 1:1 and the 2:1 complexes have distorted tetrahedral metal centers, while the 1:2 structure is five-coordinate with a square pyramidal geometry. FTIR results, together with EDS data and DFT calculations, established that the complex obtained in the solid state likely consists of a polymeric arrangement involving repetition of the 1:2 complex unit. These results are relevant in the context of the study of the toxicity of IC and provide crucial data for future studies of its physiological effects. Although the general population does not normally exceed the maximum recommended daily intake, young children are highly exposed to products containing IC and can easily exceed the recommended dose. It is, therefore, extremely important to understand the interactions between the dye and the various metal ions present in the human body, copper(II) being one of the most relevant due to its essential nature and, as shown in this article, the high stability of the complexes it forms with IC at physiological pH.
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Probing quantum mechanical tunneling (QMT) in chemical reactions is crucial to understanding and developing new transformations. Primary H/D kinetic isotopic effects (KIEs) beyond the semiclassical maximum values of 7-10 (room temperature) are commonly used to assess substantial QMT contributions in one-step hydrogen transfer reactions, because of the much greater QMT probability of protium vs. deuterium. Nevertheless, we report here the discovery of a reaction model occurring exclusively by H-atom QMT with residual primary H/D KIEs. 2-Hydroxyphenylnitrene, generated in N2 matrix, was found to isomerize to an imino-ketone via sequential (domino) QMT involving anti to syn OH-rotamerization (rate determining step) and [1,4]-H shift reactions. These sequential QMT transformations were also observed in the OD-deuterated sample, and unexpected primary H/D KIEs between 3 and 4 were measured at 3 to 20â K. Analogous residual primary H/D KIEs were found in the anti to syn OH-rotamerization QMT of 2-cyanophenol in a N2 matrix. Evidence strongly indicates that these intriguing isotope-insensitive QMT reactivities arise due to the solvation effects of the N2 matrix medium, putatively through coupling with the moving H/D tunneling particle. Should a similar scenario be extrapolated to conventional solution conditions, then QMT may have been overlooked in many chemical reactions.
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In this study, a commercial dental resin was reinforced by SiO2 nanoparticles (NPs) with different concentrations to enhance its mechanical functionality. The material characterization and finite element analysis (FEA) have been performed to evaluate the mechanical properties. Wedge indentation and 3-point bending tests were conducted to assess the mechanical behavior of the prepared nanocomposites. The results revealed that the optimal content of NPs was achieved at 1% SiO2, resulting in a 35% increase in the indentation reaction force. Therefore, the sample containing 1% SiO2 NPs was considered for further tests. The morphology of selected sample was examined using field emission scanning electron microscopy (FE-SEM), revealing the homogeneous dispersion of SiO2 NPs with minimal agglomeration. X-ray diffraction (XRD) was employed to investigate the crystalline structure of the selected sample, indicating no change in the dental resin state upon adding SiO2 NPs. In the second part of the study, a novel approach called iterative FEA, supported by the experiment wedge indentation test, was used to determine the mechanical properties of the 1% SiO2-dental resin. Subsequently, the accurately determined material properties were assigned to a dental crown model to virtually investigate its behavior under oblique loading. The virtual test results demonstrated that most microcracks initiated from the top of the crown and extended through its thickness.
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Nanopartículas , Dióxido de Silicio , Dióxido de Silicio/química , Resinas Compuestas/química , Análisis de Elementos Finitos , Nanopartículas/química , Fenómenos Mecánicos , Ensayo de MaterialesRESUMEN
Two simple nitroxyl radicals, di-tert-butyl nitroxyl (DTBN) and 2,2,6,6-tetramethylpiperidinyloxyl (TEMPO) are solvated by one or two water, methanol, tert-butyl alcohol or phenol molecules. The resulting low temperature IR spectra of the vacuum-isolated microsolvates in the OH stretching range are assigned based on harmonic DFT predictions for closed shell solvent dimers and trimers and their offset from experiment, to minimise theory-guided assignment bias. Systematic conformational preferences for the first and second solvent molecule are observed, depending on the conformational rigidity of the radical. These assignments are collected into an experimental benchmark data set and used to assess the spectral predicting power of different DFT approaches. The goal is to find inexpensive computational methods which provide reliable spectral predictions for this poorly explored class of microsolvates.
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Piezoelectric nanogenerators (PENGs) have attracted great interest owing to their broad range application in environmental mechanical energy harvesting to power small electronic devices. In this study, novel flexible and high-performance double-layer sandwich-type PENGs based on one-dimensional (1-D) and two-dimensional (2-D) zinc oxide (ZnO) nanostructures and Ni foam as the middle layer have been developed. The morphology and structure of 1- and 2-D ZnO nanostructures have been studied by scanning electron microscopy (SEM) and X-ray diffraction (XRD). To investigate the effect of structural design on the piezoelectric performance, single-layer PENGs were also fabricated. The piezoelectric output of all prepared PENGs were evaluated under different human impacts at various forces and frequencies. The double-layer designed PENGs showed a two times larger voltage output compared to the single-layer PENGs, and the use of Ni foam as middle-layer and of 2-D ZnO nanosheets (compared to 1-D nanorods) was also found to increase the performance of the designed PENGs. The working mechanism of the prepared PENGs is also discussed. The design of nanogenerators as double-layer sandwich structures instead of two integrated single-layer devices reduces the overall preparation time and processing steps and enhances their output performance, thus opening the gate for widening their practical applications.
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The molecular structure and photochemistry of dispiro[cyclohexane-1,3'-[1,2,4,5]tetraoxane-6',2''-tricyclo[3.3.1.13,7 ]decan]-4-one (TX), an antiparasitic 1,2,4,5-tetraoxane was investigated using matrix isolation IR and EPR spectroscopies, together with quantum chemical calculations undertaken at the DFT(B3LYP)/6-311++G(3df,3pd) level of theory, with and without Grimme's dispersion correction. Photolysis of the matrix-isolated TX, induced by inâ situ broadband (λ>235â nm) or narrowband (λ in the range 220-263â nm) irradiation, led to new bands in the infrared spectrum that could be ascribed to two distinct photoproducts, oxepane-2,5-dione, and 4-oxohomoadamantan-5-one. Our studies show that these photoproducts result from initial photoinduced cleavage of an O-O bond, with the formation of an oxygen-centered diradical that regioselectivity rearranges to a more stable (secondary carbon-centered)/(oxygen-centered) diradical, yielding the final products. Formation of the diradical species was confirmed by EPR measurements, upon photolysis of the compound at λ=266â nm, in acetonitrile ice (T=10-80â K). Single-crystal X-ray diffraction (XRD) studies demonstrated that the TX molecule adopts nearly the same conformation in the crystal and matrix-isolation conditions, revealing that the intermolecular interactions in the TX crystal are weak. This result is in keeping with observed similarities between the infrared spectrum of the crystalline material and that of matrix-isolated TX. The detailed structural, vibrational, and photochemical data reported here appear relevant to the practical uses of TX in medicinal chemistry, considering its efficient and broad parasiticidal properties.
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Monomers of benzimidazole trapped in an argon matrix at 15 K were characterized by vibrational spectroscopy and identified as 1H-tautomers exclusively. The photochemistry of matrix-isolated 1H-benzimidazole was induced by excitations with a frequency-tunable narrowband UV light and followed spectroscopically. Hitherto unobserved photoproducts were identified as 4H- and 6H-tautomers. Simultaneously, a family of photoproducts bearing the isocyano moiety was identified. Thereby, the photochemistry of benzimidazole was hypothesized to follow two reaction pathways: the fixed-ring and the ring-opening isomerizations. The former reaction channel results in the cleavage of the NH bond and formation of a benzimidazolyl radical and an H-atom. The latter reaction channel involves the cleavage of the five-membered ring and concomitant shift of the H-atom from the CH bond of the imidazole moiety to the neighboring NH group, leading to 2-isocyanoaniline and subsequently to the isocyanoanilinyl radical. The mechanistic analysis of the observed photochemistry suggests that detached H-atoms, in both cases, recombine with the benzimidazolyl or isocyanoanilinyl radicals, predominantly at the positions with the largest spin density (revealed using the natural bond analysis computations). The photochemistry of benzimidazole therefore occupies an intermediate position between the earlier studied prototype cases of indole and benzoxazole, which exhibit exclusively the fixed-ring and the ring-opening photochemistries, respectively.
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6-Bromopyridine-2-carbaldehyde (abbreviated as BPCA) is used both as a building block in supramolecular chemistry and as a ligand for transition metal catalysts and luminescent complexes. In this study, the structure and vibrational spectra of BPCA were investigated in both the room temperature neat crystalline phase and for the compound isolated in cryogenic Ar, Kr and Xe matrices. The experimental studies were complemented by quantum chemical DFT(B3LYP)/6-311++G(d,p) calculations. For the crystalline compound, infrared and Raman spectra were obtained and interpreted. Comparison of the obtained infrared spectrum of the crystal with those obtained for the isolated molecules of BPCA in the studied cryomatrices helped to conclude that the intermolecular interactions in the crystal do not significantly perturb the intramolecular vibrational potential. Structural analysis further supports the existence of weak coupling between the intermolecular interactions and the structure of the constituting molecular units in crystalline state. The intermolecular interactions in the BPCA crystal were also evaluated by means of Hirshfeld analysis, which revealed that the most important interactions are weak and of the H N, H O, H H, H Br and Br Br types. The conformer of BPCA present in the crystal was found to correspond to the most stable form of the isolated molecule (trans), which bears stabilizing C-H O=C and C(=O)H N interactions. This conformer was shown to be the single conformer present in the as-deposited cryogenic matrices prepared from the room temperature gaseous compound. Broadband UV irradiation of matrix-isolated BPCA (λ ≥ 235 nm) resulted in the conversion of the trans conformer into the higher-energy cis conformer, where repulsive C-H H-C(=O) and C=OLP LPN (where LP designates a lone electron pair) interactions are present, and decarbonylation of the compound with formation of 2-bromopyridine (plus CO). The decarbonylation reaction was found to be more efficient in the more polarizable Xe matrix, indicating stabilization of the radicals initially formed upon breaking of the C-C(HO) and C-H (aldehyde) bonds in this medium, and testifying the occurrence of the decarbonylation reaction with involvement of radical species. TD-DFT calculations were used to access the nature of the excited states associated with the observed UV-induced reactions. As a whole, this study provides fundamental data to understand the physicochemical behavior of the compound, bridging the properties of the isolated molecule to those of the neat crystalline com-pound. Such information is of fundamental importance for the understanding of the role of BPCA in supramolecular chemistry and to potentiate its applications in synthesis and as a ligand for transition metal catalysts and luminescent complexes.
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Rayos Ultravioleta , Vibración , Ligandos , Espectroscopía Infrarroja por Transformada de FourierRESUMEN
Water pollution poses a global threat to ecosystems and human health and is driven by the presence of various contaminants in wastewater, including nano- and microplastics. Despite the magnitude of this problem, the majority of global wastewater is released untreated into water bodies. To combat this issue, a multi-strategy approach is needed. This study explores a circular economy-based solution for treating emerging pollutants, particularly wastewater from ophthalmic spectacle lens production. Our approach integrates solid waste materials into polymeric and cement matrices while also utilising wastewater for microalgae cultivation. This innovative strategy focuses on biomass generation and economic valorisation. By adopting a circular economy model, we aim to transform environmental pollutants from wastewater into valuable organic products. A key component of our approach is the utilisation of microalgae, specifically Nannochloropsis sp., known for its high lipid content and resilience. This microalgae species serves as a promising biobased feedstock, supporting the production of innovative biobased products, such as biopolymers, for ophthalmic lens manufacturing. Our interdisciplinary approach combines microalgae technology, analytical chemistry, cement production, and polymer processing to develop a sustainable circular economy model that not only addresses environmental concerns, but also offers economic benefits. This study underscores the potential of harnessing high-value products from waste streams and underscores the importance of circular economy principles in tackling pollution and resource challenges.
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Monomers of meta-fluorophenol (mFP) were trapped from the gas phase into cryogenic argon and nitrogen matrices. The estimated relative energies of the two conformers are very close, and in the gas phase they have nearly equal populations. Due to the similarity of their structures (they only differ in the orientation of the OH group), the two conformers have also similar predicted vibrational signatures, which makes the vibrational characterization of the individual rotamers challenging. In the present work, it has been established that in an argon matrix only the most stable trans conformer of mFP exists (the OH group pointing away from the fluorine atom). On the other hand, the IR spectrum of mFP in a nitrogen matrix testifies to the simultaneous presence in this matrix of both the trans conformer and of the higher-energy cis conformer (the OH group pointing toward the fluorine atom), which is stabilized by interaction with the matrix gas host. We found that the exposition of the cryogenic N2 matrix to the Globar source of the infrared spectrometer affects the conformational populations. By collecting experimental spectra, either in the full mid-infrared range or only in the range below 2200 cm-1, we were able to reliably distinguish two sets of experimental bands originating from individual conformers. A comparison of the two sets of experimental bands with computed infrared spectra of the conformers allowed, for the first time, the unequivocal vibrational identification of each of them. The joint implementation of computational vibrational spectroscopy and matrix-isolation infrared spectroscopy proved to be a very accurate method of structural analysis. Some mechanistic insights into conformational isomerism (the quantum tunneling of hydrogen atom and vibrationally-induced conformational transformations) have been addressed. Finally, we also subjected matrix-isolated mFP to irradiations with UV light, and the phototransformations observed in these experiments are also described.
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Nitrógeno , Rayos Ultravioleta , Argón/química , Nitrógeno/química , Conformación Molecular , Espectrofotometría InfrarrojaRESUMEN
We present here a new example of chemical reactivity governed by quantum tunneling, which also highlights the limitations of the classical theories. The syn and anti conformers of a triplet 2-formylphenylnitrene, generated in a nitrogen matrix, were found to spontaneously rearrange to the corresponding 2,1-benzisoxazole and imino-ketene, respectively. The kinetics of both transformations were measured at 10 and 20 K and found to be temperature-independent, providing clear evidence of concomitant tunneling reactions (heavy-atom and H-atom). Computations confirm the existence of these tunneling reaction pathways. Although the energy barrier between the nitrene conformers is lower than any of the observed reactions, no conformational interconversion was observed. These results demonstrate an unprecedented case of simultaneous tunneling control in conformer-specific reactions of the same chemical species. The product outcome is impossible to be rationalized by the conventional kinetic or thermodynamic control.
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Nitrógeno , Conformación Molecular , Termodinámica , Cinética , TemperaturaRESUMEN
Hydrogen bonding (HB) has been receiving attention from both experimental and theoretical researchers since its discovery in the 1920s due to its impact on many chemical and biological processes. However, despite the large number of investigations conducted on this topic, the nature of the HBs and, in particular, the estimation of intramolecular HB energies are still very active subjects of research. In this context, here we report a matrix isolation infrared spectroscopy study of 2,3-dihydroxybenzaldehyde (2,3-DHBA) and 2,4-dihydroxybenzaldehyde (2,4-DHBA), which contain two [one resonance-assisted HB (RAHB) and one conventional HB] and one (RAHB) intramolecular hydrogen bonds, respectively, in their most stable conformer. After isolation of the compounds in cryogenic (15 K) krypton matrices, ultraviolet irradiation led to the formation of higher-energy conformers (by a 180° rotation of the hydroxyl and aldehyde groups), which implies breaking of the intramolecular HBs initially existing in the isolated species and, in the case of 2,3-DHBA, to the formation of a new intramolecular HB. In this way, we were able to manipulate the structure of the molecules, allowing to characterize a diversity of intramolecular HBs in which the OH groups participate (from strong intramolecular RAHBs to weaker conventional HBs, and also no intramolecular HBs) through the corresponding vibrational signatures. The spectroscopic studies were complemented by natural bond orbital analysis and the molecular tailoring approach method, in order to estimate the relative intramolecular HB energies and explore the substitution effects on HB strength.
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Aldehídos , Vibración , Humanos , Enlace de Hidrógeno , Temperatura , Aldehídos/química , Espectrofotometría InfrarrojaRESUMEN
Quantum mechanical tunneling of heavy-atoms and vibrational excitation chemistry are unconventional and scarcely explored types of reactivity. Once fully understood, they might bring new avenues to conduct chemical transformations, providing access to a new world of molecules or ways of exquisite reaction control. In this context, we present here the discovery of two isomeric benzazirines exhibiting differential tunneling-driven and vibrationally-induced reactivity, which constitute exceptional results for probing into the nature of these phenomena. The isomeric 6-fluoro- and 2-fluoro-4-hydroxy-2H-benzazirines (3-a and 3'-s) were generated in cryogenic krypton matrices by visible-light irradiation of the corresponding triplet nitrene 3 2-a, which was produced by UV-light irradiation of its azide precursor. The 3'-s was found to be stable under matrix dark conditions, whereas 3-a spontaneously rearranges (τ1/2 â¼64â h at 10 and 20â K) by heavy-atom tunneling to 3 2-a. Near-IR-light irradiation at the first OH stretching overtone frequencies (remote vibrational antenna) of the benzazirines induces the 3'-s ring-expansion reaction to a seven-member cyclic ketenimine, but the 3-a undergoes 2H-azirine ring-opening reaction to triplet nitrene 3 2-a. Computations demonstrate that 3-a and 3'-s have distinct reaction energy profiles, which explain the different experimental results. The spectroscopic direct measurement of the tunneling of 3-a to 3 2-a constitutes a unique example of an observation of a species reacting only by nitrogen tunneling. Moreover, the vibrationally-induced sole activation of the most favorable bond-breaking/bond-forming pathway available for 3-a and 3'-s provides pioneer results regarding the selective nature of such processes.
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Anhydrous carbamazepine (CBZ) is an anti-convulsant drug commonly used to treat epilepsy and relieve trigeminal neuralgia. The presence of the dihydrate form in commercial CBZ tablets can change the dissolution rate of the active pharmaceutical ingredient (API), thus decreasing its activity. The hydration transformation can occur during wet granulation or storage, within a few weeks, depending on the ambient conditions. This work aims to investigate the effect of relative humidity (RH) in the transition of pure anhydrous CBZ (CBZ III) into the hydrate form by using confocal Raman microscopy with cluster analysis (CA). Firstly, several tablets of pure CBZ III containing different amounts of CBZ DH (50%, 10%, 1%, 0.5%) were prepared and analyzed by Raman imaging with CA. Our results show that CBZ DH crystals can be detected in the CBZ III tablets, at as low a concentration as 0.5%, giving distinct Raman features for the analysed polymorphs. The stability of pure anhydrous (CBZ III) tablets was then monitored by Raman imaging at room temperature (20-22 °C) and different RH (6%, 60% and 89%). The Raman imaging with CA showed that the anhydrous CBZ tablets start to convert into the hydrate form after 48 h, and it completely changes after 120 hours (5 days) at RH 89%. The tablets exposed to RH 6% and 60% did not demonstrate the presence of CBZ DH after 1 week of exposure. The exposure time was extended for 9 months in the former, and no CBZ DH was observed. A comparative study using IR imaging was also performed, demonstrating the viability of these vibrational imaging techniques as valuable tools to monitor the hydration process of active pharmaceutical ingredients.
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Carbamazepina , Carbamazepina/análisis , Carbamazepina/química , Cristalización , Solubilidad , ComprimidosRESUMEN
Plasmodium falciparum artemisinin-resistance boosted the quest for novel plasmodial "fast killers," uncovering antimalarial candidates OZ439 and E209, whose peroxide precursors are 1,2,4-trioxolane (1) and 1,2,4,5-tetraoxane (2), differing solely in the pharmacophore (trioxolane or tetraoxane). Combining X-ray crystallography and vibrational spectroscopy, along with Hirshfeld surface analysis and calculations (CE-B3LYP/6-31G(d,p)) of pairwise interaction energies of intermolecular contacts existing in the crystal structure, may deepen the understanding of relative reactivity and properties of these endoperoxides classes. In the crystal, the tetraoxane ring in 2 and the trioxolane-adamantyl fragment in 1 are disordered, with molecules 1 and 2 existing as two distinct, stable conformations. Whereas the dominant C-Hâ â â O H-bonds in 1 connect an adamantyl C-H and O1 or O2 of the trioxolane ring, in 2 they involve the carbonyl oxygen, acting as a double acceptor from phenyl ring C-H groups. C-Hâ â â O and C-Hâ â â π H-bonds define the molecular packing of 2, while C-Hâ â â H-C van der Waals interactions determine the packing of 1. The dispersive component dominates the interaction energies calculated for the most representative molecular pairs.
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Antimaláricos , Tetraoxanos , Antimaláricos/química , Antimaláricos/farmacología , Antiparasitarios , Estructura Molecular , Peróxidos/química , Tetraoxanos/química , Tetraoxanos/farmacologíaRESUMEN
Polycarbonate (PC)-ZnO films with different percentages of ZnO were prepared by a solution stirring technique and subjected to ultraviolet (UV; λ = 254 nm) irradiation. Structural parameters of the samples and the effects of UV irradiation on the surface properties of the PC and PC-ZnO nanocomposites were evaluated by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), water contact angle (WCA) measurements, and a Vickers microhardness (HV) tester. The XRD patterns of the nanocomposite films were found to show an increase in crystallinity with the increasing ZnO nanoparticles percentage. The WCA was found to be reduced from 90° to 17° after 15 h of UV irradiation, which could be ascribed to the oxidation of the surface of the samples during the irradiation and exposure of the ZnO nanoparticles, a result that is also supported by the obtained XPS data. The microhardness value of the PC-ZnO films including 30 wt.% ZnO enhanced considerably after UV radiation, which can also be attributed to the exposition of the ZnO nanoparticles after photodegradation of the PC superficial layer of the nanocomposite films.
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5-Chlorosalicylaldehyde (abbreviated as 5CSA) is an important chemical used in the synthesis of fragrances, dyes, and pharmaceuticals. In this investigation, 5CSA isolated in solid N2, at 10 K, and in its neat amorphous and crystalline phases, at 50 and 190 K, respectively, were investigated by infrared spectroscopy and DFT(B3LYP)/6-311++G(d,p) calculations. The systematic theoretical analysis of the 5CSA conformational landscape showed that the compound exhibits four different conformers, which were structurally characterized in detail. In the as-deposited low-temperature matrices of 5CSA, only the most stable conformer, the intramolecularly hydrogen-bonded form I, was found. The same was observed in the case of the investigated low-temperature amorphous and crystalline phases of 5CSA. Conformer I was successfully converted into a higher-energy conformer(II), where both aldehyde and hydroxyl groups are rotated by 180° relative to their position in the initial conformer, through narrowband ultraviolet (UV) (λ = 308 nm) in situ irradiation of the as-deposited N2 matrix of 5CSA. The infrared spectra of both matrix-isolated conformers, as well as those of the neat amorphous and crystalline phases of 5CSA, were assigned and interpreted in comparative terms, allowing us to elucidate structurally and vibrationally relevant effects of the main intra- and intermolecular interactions operating in the different studied phases. Very interestingly, the observed UV-induced I â II rotamerization was found to take place in an exclusive basis, with no other photochemical processes being observed to occur upon UV irradiation, under the experimental conditions used in the present investigation.
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Procesos Fotoquímicos , Rayos Ultravioleta , Conformación Molecular , Espectrofotometría Infrarroja , TemperaturaRESUMEN
Fumaric and maleic acids ((E)- and (Z)-HOOC-CHâCH-COOH, FA and MA) were studied experimentally by infrared spectroscopy in nitrogen matrixes and theoretically by quantum chemical calculations. The calculations, carried out at the DFT(B3LYP) and MP2 levels of theory, predicted the existence of at least 5 conformers of maleic acid and 10 conformers of fumaric acid. After the deposition of the matrixes, two conformers of maleic acid (I and II) and three conformers (I-III) of fumaric acid were observed and characterized vibrationally. Selective narrowband near-infrared (NIR) excitation of the first OH stretching overtones of the different conformers of maleic and fumaric acids initially present in the matrixes allowed the generation of higher-energy forms, never before observed experimentally. In the case of maleic acid, conformers I (a cis-trans form, where cis and trans designate the conformation of the carboxylic groups of the molecule) and II (cis-cis) were found to generate the novel conformers VI (trans-trans) and VII (cis-trans), respectively. The conversion of conformer II into the most stable conformer I was also observed. For fumaric acid, the cis-cis conformers I-III were found to give rise to the new cis-trans conformers IV-VII, respectively. The tunneling decay of the new conformers produced upon NIR excitation of the lowest-energy conformers initially trapped in the matrixes was observed, and their lifetimes in solid N2 were determined. The increased stability of all of the observed high-energy conformers of the studied acids in the N2 matrix, compared to the argon matrix, where they could not be observed experimentally, demonstrates the stabilizing effect of the interaction between the OH groups of the acids with the matrix N2 molecules, in line with previous observations for other carboxylic acids. In addition, the photochemistry of matrix-isolated maleic and fumaric acids upon broad-band UV irradiation (λ > 235 nm) was also investigated. UV-induced isomerization of both acids around the CâC double bond was observed, together with their decarboxylation to acrylic acid.