RESUMEN
During 1979 4 patients were observed who developed short episodes of fever as high as 104 degrees F after oral intake of 25--100 mg nomifensine (Alival). In all four cases a clear fever spike was produced by reexposure to the drug. The reaction time was 4--6 hours. this drug-induced fever appeared initially 2--4 weeks after the commencement of Alival therapy. No other cause for the fever was identifiable. In one patient an allergic alveolitis was suspected to be a further reaction. In another patient a concomitant granulomatous hepatitis was possibly also due to this drug. It is probable that the febrile reactions have an allergic mechanism. Allergologic investigations have not yet been completed.
Asunto(s)
Fiebre/inducido químicamente , Isoquinolinas/efectos adversos , Nomifensina/efectos adversos , Anciano , Hipersensibilidad a las Drogas/inmunología , Humanos , Activación de Linfocitos , Masculino , Persona de Mediana EdadRESUMEN
Serial white blood cell counts were studied in 20 healthy full-term babies and 252 newborn babies of different birthweights (61 of them without and 191 with perinatal risks). Nonsegmented (band form) and segmented neutrophils participate in roughly equal quantities in the physiological postnatal neutrophil reaction, which begins 1 hour after birth (8100/mm3 +/- 2600), reaches the peak after 9 hours (15 500/mm3 +/- 4000), and drops to the initial level within 42 hours. During the first 3 days the shift to the left with the relative and absolute increase of the band forms is more significant for a perinatal infection than the rise of total neutrophil count, which can remain within the normal range. However, these changes are not specific for infectious diseases. In the period the white blood count has only a diagnostic value in relation with the age of the newborn in hours and with short term follow-ups. Newborns of low birth weight (under 2500 g) show lower absolute counts and less significant changes than newborns of normal birth weight.