RETROSPECTIVE EPIDEMIOLOGIC RESEARCH ON PREVALENCE OF INFECTIONS IN SURGICALLY TREATED ONCOLOGIC PATIENTS.

UNLABELLED: The aim of this work was the retrospective study of the frequency of infections in surgically treated oncologic patients. MATERIAL AND METHODS: Our research included 753 oncologic patients treated at the Second Surgical Clinic of the Regional Institute of Oncology, Iasi, between January 2013 and December 2014, with the selection of cases which had infectious complications. RESULTS: The lot of patients was structured in 7 age groups and the most frequent oncologic patients had ages between 60-79 years. The most frequent malignancies were large bowel, breast, rectal, esophageal cancers, malignant hemopathies, gastric and liver malignant tumors. In our lot of 753 oncologic patients we depicted 113 (15.01%) infections. CONCLUSIONS: Our study proved that the anatomic location of the cancer, the hospitalization duration and the number of the hospitalizations has an important role in appearance of the infectious complications. The gastrointestinal malignant tumors were the most frequent malignancies associated with postoperative infections. The patients with gastrointestinal cancers from urban area, with ages between 50 and 79 years had the highest risk of infectious complications. For main causative organism was proved a high sensitivity for colistin. Clinical, paraclinical and epidemiological exams did not emphasize any decisive factors; we took into account the risks of infection during multiple pre-, intra- and postoperative procedures; all these have been associated with increased receptivity of immunosuppressed oncologic patients.

Clinical epidemiological study on the incidence of Escherichia coli infections in the cancer patients admitted to Surgery Department II of the Iasi Regional Oncology Institute in 2013.

UNLABELLED: The aim of study was to identify pathogens involved in hospital-acquired or community-acquired infections in patients suffering from various types of cancers. MATERIAL AND METHODS: A clinical epidemiological study included a group of 355 cancer patients admitted and operated at the Surgery Department II of the Iasi Regional Oncology Institute in 2013 was performed using data from hospital statistical service and the surgery and laboratory records, then processed by epidemi ological and statistical methods. RESULTS: In cancer patients the pathogen most commonly involved in infections was E. coli, followed by Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis, Enterobacter cloacae and Acinetobacter. Analysis of bacterial resistance to antibiotics of the pathogen most commonly involved revealed that of the 29 E. coli strains 22 were tested for resistance/sensitivity to ampicillin; of these, 19 strains showed resistance, and only 3 were sensitive; 14 E. coli strains of were resistant to cephalosporins and 8 sensitive; all strains tested were sensitive to carbapenems, imipenem or meropenem and polypeptides (colistin); the 10 tested strains showed resistance to monobactams (aztreonam). CONCLUSIONS: E. coli was incriminated in most urinary tract infections, the other pathogens being identified sporadically. Surgical wound infections were caused mostly by E. coli and Staphylococcus aureus, followed by Pseudomonas aeruginosa. In our study we encountered increased resistance of E. coli to penicillins, cephalosporins, monobactams (aztreonam), fluoro-quinolones and tetracyclines.