RESUMEN
INTRODUCTION: Cyclosporine Neoral is a major immunosuppressive agent widely used in organ transplant populations. Its pharmacokinetics are influenced by various factors. The aim of this study was to investigate the effects of orange or tangerine juice on the pharmacokinetic pattern of cyclosporine Neoral among renal transplanted patients. MATERIALS AND METHODS: Ten renal transplant recipients on cyclosporine Neoral-based immunosuppressive therapy were included in this crossover controlled study. Patients were given their individualized morning dose of cyclosporine with either 250 mL water or 250 mL orange or tangerine juice; 12-hour cyclosporine pharmacokinetic investigations were performed. The three investigation days were separated by at least 7 days. RESULTS: The intake of orange juice did not have any significant influence on the area under the curve in the interval from 0 to 12 hours (AUC 0-12; 95% confidence interval [CI]: -769 to 734, P=.77), or the maximum whole blood concentration (Cmax; 95% CI: 264 to 74; P=.32). Similarly, after coadministration of cyclosporine Neoral with tangerine juice, no significant changes were observed in AUC 0-12 (95% CI: -453 to 1166; P=.28) or Cmax (95% CI: -239 to 179; P=.37). CONCLUSION: Coadministration of orange (var Tampson) or tangerine (var Unshiu) juice with cyclosporine compared with water did not influence exposure to cyclosporine in renal transplant recipients.
Asunto(s)
Bebidas , Citrus , Ciclosporina/farmacocinética , Trasplante de Riñón/inmunología , Área Bajo la Curva , Estudios Cruzados , Ciclosporina/sangre , Ciclosporina/uso terapéutico , Humanos , Inmunosupresores/farmacocinética , Inmunosupresores/uso terapéuticoRESUMEN
We determined the prevalence of Chlamydia trachomatis infection and risk factors for infection among 550 sexually active women < 45 years attending gynaecology clinics in Babol, Islamic Republic of Iran. The women were interviewed about sociodemographic and behavioural variables associated with the infection and underwent pelvic examination and blood tests. The prevalence of C. trachomatis was 11.6%. There was a significant association between C. trachomatis infection and income, husband's education and woman's age (< 25 years), and also drug addiction of husband, non-use of condoms and not having heard of sexually transmitted infections. The only clinical signs significantly associated with infection were cervical friability and mucopurulent cervicitis.
Asunto(s)
Infecciones por Chlamydia/epidemiología , Infecciones por Chlamydia/etiología , Chlamydia trachomatis , Mujeres , Adulto , Distribución por Edad , Actitud Frente a la Salud , Infecciones por Chlamydia/diagnóstico , Infecciones por Chlamydia/psicología , Centros Comunitarios de Salud/estadística & datos numéricos , Condones/estadística & datos numéricos , Femenino , Conocimientos, Actitudes y Práctica en Salud , Humanos , Renta , Irán/epidemiología , Persona de Mediana Edad , Vigilancia de la Población , Prevalencia , Factores de Riesgo , Conducta Sexual/psicología , Conducta Sexual/estadística & datos numéricos , Esposos/educación , Esposos/psicología , Esposos/estadística & datos numéricos , Trastornos Relacionados con Sustancias/complicaciones , Encuestas y Cuestionarios , Salud Urbana/estadística & datos numéricos , Cervicitis Uterina/microbiología , Mujeres/educación , Mujeres/psicologíaRESUMEN
We determined the prevalence of Chlamydia trachomatis infection and risk factors for infection among 550 sexually active women < 45 years attending gynaecology clinics in Babol, Islamic Republic of Iran. The women were interviewed about sociodemographic and behavioural variables associated with the infection and underwent pelvic examination and blood tests. The prevalence of C. trachomatis was 11.6%. There was a significant association between C. trachomatis infection and income, husband's education and woman's age [< 25 years], and also drug addiction of husband, non-use of condoms and not having heard of sexually transmitted infections. The only clinical signs significantly associated with infection were cervical friability and mucopurulent cervicitis.