Women's interest in a personal breast cancer risk assessment and lifestyle advice at NHS mammography screening.

Background: Although mortality from breast cancer is declining, incidence continues to increase and is often detected at routine NHS screening. Most middle aged and older women in England attend for screening every 3 years. Assessing their personal breast cancer risk and providing preventative lifestyle advice could help to further reduce breast cancer incidence. Methods: A cross-sectional, self-complete postal survey measured attendees' interest in having a personal risk assessment, expected impact on screening attendance, knowledge of associations between lifestyle and breast cancer and preferred ways of accessing preventative lifestyle advice. Results: A total of 1803/4948 (36.4%) completed questionnaires were returned. Most participants (93.7%) expressed interest in a personal risk assessment and 95% (1713/1803) believed it would make no difference or encourage re-attendance. Two-thirds (1208/1803) associated lifestyle with breast cancer, but many were unaware of specific risks such as weight gain, obesity, alcohol consumption and physical inactivity. NHS sourced advice was expected to be more credible than other sources, and booklets, brief counselling or an interactive website were most preferred for accessing this. Conclusions: Attendees appear to welcome an intervention that would facilitate more proactive clinical and lifestyle prevention and address critical research gaps in breast cancer prevention and early detection.

Cardiovascular complications induced by cannabis smoking: a case report and review of the literature.

Cannabis is generally considered a drug of low toxicity. Although attention has focused on its neuropsychiatric effects, little has been given to cardiovascular side effects. Here we report a case of atrial tachyarrhythmias following cannabis use, and review the literature on its cardiovascular effects and complications.

Atrial flutter following a wasp sting.

Wasp stings have been associated with a wide variety of local and systemic reactions including, rarely, tachyarrhythmias. We discuss a case of atrial flutter occurring in a 64-year-old man following a single sting in the absence of anaphylaxis. The pathogenesis is discussed and the literature reviewed.

Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses.

Immunological unresponsiveness or hyporesponsiveness (tolerance) can be induced by feeding protein antigens to naive animals. Using a classical oral ovalbumin gut-induced tolerance protocol in BALB/c mice we investigated the effects of dietary n-6 and n-3 polyunsaturated fatty acids (PUFA) on high-and low-dose oral tolerance (and in non-tolerised animals, i.e. effects of antigen challenge alone) in relation to lymphoproliferative, cytokine and antibody responses. Fish oil rich in long-chain n-3 fatty acids decreased both T-helper (Th) 1- and Th2-like responses. In contrast, borage (Borago officinalis) oil rich in n-6 PUFA, of which gamma-linolenic acid is rapidly metabolised to longer-chain n-6 PUFA, increased Thl-like responses and decreased Th2-like responses, and possibly enhanced suppressor cell or Th3-like activity. These findings are in general agreement with other studies on the effects of long chain n-3 PUFA on immune system functions, and characterise important differences between long-chain n-3 and n-6 PUFA, defining more precisely and broadly the immunological regulatory mechanisms involved. They are also discussed in relation to autoimmune disease.

Protection of Macaca nemestrina from disease following pathogenic simian immunodeficiency virus (SIV) challenge: utilization of SIV nucleocapsid mutant DNA vaccines with and without an SIV protein boost.

Molecular clones were constructed that express nucleocapsid (NC) deletion mutant simian immunodeficiency viruses (SIVs) that are replication defective but capable of completing virtually all of the steps of a single viral infection cycle. These steps include production of particles that are viral RNA deficient yet contain a full complement of processed viral proteins. The mutant particles are ultrastructurally indistinguishable from wild-type virus. Similar to a live attenuated vaccine, this approach should allow immunological presentation of a full range of viral epitopes, without the safety risks of replicating virus. A total of 11 Macaca nemestrina macaques were inoculated with NC mutant SIV expressing DNA, intramuscularly (i.m.) in one study and i.m. and subcutaneously in another study. Six control animals received vector DNA lacking SIV sequences. Only modest and inconsistent humoral responses and no cellular immune responses were observed prior to challenge. Following intravenous challenge with 20 animal infectious doses of the pathogenic SIV(Mne) in a long-term study, all control animals became infected and three of four animals developed progressive SIV disease leading to death. All 11 NC mutant SIV DNA-immunized animals became infected following challenge but typically showed decreased initial peak plasma SIV RNA levels compared to those of control animals (P = 0.0007). In the long-term study, most of the immunized animals had low or undetectable postacute levels of plasma SIV RNA, and no CD4(+) T-cell depletion or clinical evidence of progressive disease, over more than 2 years of observation. Although a subset of immunized and control animals were boosted with SIV(Mne) proteins, no apparent protective benefit was observed. Immunization of macaques with DNA that codes for replication-defective but structurally complete virions appears to protect from or at least delay the onset of AIDS after infection with a pathogenic immunodeficiency virus. With further optimization, this may be a promising approach for vaccine development.

Mucosal challenge of Macaca nemestrina with simian immunodeficiency virus (SIV) following SIV nucleocapsid mutant DNA vaccination.

A simian immunodeficiency virus (SIV)(Mne) DNA clone was constructed that produces viruses containing a four amino acid deletion in the second zinc finger of the nucleocapsid (NC) domain of the Gag polyprotein. Viruses produced from this clone, although non-infectious both in vitro and in vivo, complete a majority of the steps in a single retroviral infection cycle. Eight pig-tailed macaques (Macaca nemestrina) were inoculated intramuscularly and subcutaneously three times over the course of 24 weeks with the NC mutant expressing DNA. These macaques, and four controls, were then challenged mucosally (intrarectally) with the homologous virus (SIV Mne CL E11S) and monitored for evidence of infection and clinical disease. Prior to challenge, a measurable humoral immune response was noted in four of eight immunized macaques. After challenge, all 12 macaques became infected, although four immunized animals greatly restricted their viral replication, and one immunized animal that controlled replication remains antibody negative. No disease has been evidence during the 46-week period of monitoring after challenge.

Enhancing the medical practice: consorting with the emergency department.

In 1994, the Department of Emergency Medicine at Loma Linda University Medical Center (LLUMC) set out to implement a comprehensive emergency department (ED) model: a model that headed in the opposite direction of popularized solutions of which the objective is to keep patients out of the ED. This model increases the number of services offered. It triages patients within its walls to an area cost effective for the patient's acuity and allows patients to immediately move to a higher level of care if the provider sees the need. Three years of data have determined the comprehensive ED model to be an effective, patient-focused alternative to the "demand management" methods. Low-acuity patients at LLUMC are treated in less costly areas. The high-tech-laden "MainED" is better utilized because of a 25% increase in complex patients since 1993. In addition, the comprehensive ED model appears to be a valuable resource that enhances the outpatient medical practice.

Physician autonomy in the managed care era: the physician-citizen or subject?

Until recently, medicine was one of the few areas in which an individual could practice a profession as a citizen member of the organization. However, in the recent overhauling of medical organizations in search of cost efficiency, physicians have moved from self-governing organizations with the rights of citizen participation to autocratic, centrally controlled organizations with little for physicians to do but provide high-quality manual labor. The principles of prosperity and choice espoused in The Federalist Papers are governance principles that can re-establish citizenship in medical groups.

Future of the emergency physician: subject or citizen?

Seventy-seven percent of emergency physicians (EPs) work as either employees or independent contractors (ICs). In contrast, other hospital-based physicians such as radiologists and anesthesiologists have a much higher percentage of ownership in their medical practices. The development of a high percentage of nonownership arrangements among EPs finds a useful historical comparison in the industrialization of nonhealth care workers over the past 100 years. Unless significant changes occur in emergency medicine (EM) organization and practice structures, EPs will have less self-determination over their practice compared with other specialties. This will inevitably result in less self-determination for their future. Combined with the great strides EM has achieved as a specialty, EPs' brightest future lies in being citizens of a broader, more expansive, all encompassing EM practice.

What the role of the modern ED should be.

Managed care organizations (MCOs) have recently focused on the high cost per patient visit in the Emergency Department (ED). MCOs emphasize preventing low acuity patients access to the ED, believing that billions of healthcare dollars will be saved. However, a review of emergency department studies suggests a different outcome. Combined with new ED service lines, perhaps another, rather paradoxical approach to managing healthcare costs in the ED is more patient focused and more cost-effective long-term. This approach is more comprehensive and offers more services, not less. The ED is an important community resource and entry port to healthcare. It is the only place open 24-hours per day, 7 days per week with no appointment necessary, and all lab and radiology services available. The very claim that it is "overutilized" is an indication of its success. In large volume EDs, certain patient populations may be more specifically served with pediatric emergency, industrial medicine, and fast track physicians. Special facilities for chest pain patients or observation can treat patients more quickly, keep them out of hospital beds, thus lowering costs. In smaller hospitals, the well rounded ED physician can treat patients of all acuities. In the most rural communities the ED can become the local 24-hour clinic with short-term stay beds. EDs are fixed costs to hospitals. Extracting low acuity patients from the ED will raise costs for emergency patients and leave the facility underutilized. By appropriately raising prices for emergencies and decreasing low acuity patient charges to reflect marginal expense, the ED becomes a cost friendly environment for the low acuity patient.

Serf or citizen: physician status and organizational structure.

For more than a decade, dynamic changes in the health care industry have created new organizations for physicians. The major change for physicians has not been the organization itself, but the principles by which it is governed. This fundamental shift is studied with its impact on physicians, by analogy, becoming more like serfs or more like citizens. A review of the general organizational direction and results of non-physician health care organizations is made followed by the statistical trends of physician groups. Historical comparisons of non-health care industries are made with current organizational choices of physicians and physician groups. Observations of physician decisions are made identifying the direction they send physician status along the continuum from serf to citizen. Physicians are unknowingly making decisions regarding the principles by which they will be governed in new organizations. The choices they are making give them less autonomy and less opportunity to make future choices. The seductive invitation to spend less time in administrative matters and more time practicing medicine is a siren's call that will diminish the status of physicians and the autonomy by which medicine is practiced.

The emergency department under managed care: exploring an alternative model.

An obvious emphasis by managed care organizations is to limit emergency department care to only the most emergent patients. The result? A "lean & mean" department. However, another approach would be to encourage emergency department care--it offers more comprehensive services to both the managed care organization and the patient. And this professional paper explains how it's possible.