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1.
Cont Lens Anterior Eye ; 45(5): 101510, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-34507898

RESUMEN

PURPOSE: Astigmatism is a highly prevalent refractive error and while studies typically focus to describe the axis symmetry between eyes, little is known about the refractive symmetry. Therefore, this study determined the astigmatic power symmetry between eyes in a large clinic population. METHODS: A clinical chart review was conducted at three optometric practices in the United States, the United Kingdom and Canada and subjective refraction data from 88,891 patients 14-70 years of age who presented with at least -0.25DC refractive astigmatism in at least one eye were included in the analysis. Data were obtained at these practices between January 2014 and March 2017. The overall distribution (%) and magnitude (DC) of astigmatism was determined and refractive differences between eyes were identified. RESULTS: The mean age of the patients was 42.1 ± 15.9 years and included 51,685 (58%) female and 37,206 (42%) male patients. In this data pool of 177,782 eyes, 10.9% required zero astigmatic correction, while 56.2% had astigmatism of -0.25 to -0.75DC. In total 23.9% of patients presented with astigmatism of at least -0.75DC in only one eye, while the other eye had 0 to -0.50DC. Overall, the difference in astigmatism between eyes was less than -0.75DC for 82.1% of astigmatic patients. For patients who presented with astigmatism of -1.00DC in the right eye, 80.8% of them had an astigmatic prescription of -1.00 ± 0.50DC in the left eye. For an astigmatic prescription of -4.00DC in the right eye, only 40.6% of patients exhibited astigmatism of -4.00DC ± 0.50DC in the left eye. CONCLUSIONS: The majority of patients exhibited a difference in astigmatism between eyes of less than -0.75DC, however the refractive cylinder power symmetry was significantly lower in patients with higher refractive astigmatism.


Asunto(s)
Astigmatismo , Errores de Refracción , Adulto , Astigmatismo/diagnóstico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prescripciones , Refracción Ocular , Errores de Refracción/diagnóstico , Pruebas de Visión
2.
Transl Vis Sci Technol ; 10(2): 34, 2021 02 05.
Artículo en Inglés | MEDLINE | ID: mdl-34003919

RESUMEN

Purpose: To highlight the potential benefits for long-term use of silicone hydrogels daily disposable (DD) contact lenses, particularly with patients who are noncompliant, sleeping or napping while wearing their lenses, or those who have higher oxygen demands and wear this modality for decades. Methods: Published data for corneal swelling with lenses and no lens wear were used to develop a nonlinear least squares model. The edema load experienced with a range of oxygen transmissibilities (Dk/t) and wear compliance (sleep and napping) was determined. A mixed-effects linear regression model was used to compare the edema load for high and average corneal swellers. Results: The edema load generated demonstrates that a high Dk/t silicone hydrogel lens results in edema levels close to that with no lens wear. In comparison, hydrogels with a Dk/t of 27 (× 10-9 [cm mL{O2}][s mL mm Hg]), worn on a daily wear schedule will result in 1.5 times more edema and up to two times more if the patient is noncompliant over each decade of wear. High swellers after four decades of wear will have an edema load 10 to 17 times greater than average swellers depending on Dk/t and their degree of noncompliance with the daily wear modality. Conclusions: Prescribing silicone hydrogel DD lenses, particularly with higher DK/t, may help to maintain the long-term ocular health of patients, when they wear their lenses fulltime for many decades. Translational Relevance: Illustrates the importance of Dk/t for any CL wear modality where patients nap or sleep in lenses or have high oxygen needs.


Asunto(s)
Lentes de Contacto de Uso Prolongado , Lentes de Contacto , Edema Corneal , Córnea , Edema Corneal/etiología , Humanos , Siliconas
3.
Cont Lens Anterior Eye ; : 101436, 2021 Apr 07.
Artículo en Inglés | MEDLINE | ID: mdl-33839020
4.
Cont Lens Anterior Eye ; 42(2): 132-135, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-30413375

RESUMEN

Lack of or inadequate hand washing is a risk factor in the development of contact lens related microbial keratitis and corneal inflammatory events. In the public health domain there is compelling evidence that proper hand washing with soap can save lives. The purpose of this review is to draw attention to some of the public health literature in support of hand washing and how education can influence patients' hand hygiene behavior. Contact lens wearers are also guilty of poor hand washing behavior but there is scant evidence that education of hand washing procedures of lens wearers alters patient non-compliance. It is well known that pathogenic microbial contamination of contact lenses, lens cases, care solutions and anterior ocular components have been found with contact lens wear. However while the originating source may be hands or water, it is most likely both of these. Besides proper hand washing this paper will include mitigating strategies for avoiding microbial contamination.


Asunto(s)
Lentes de Contacto , Infecciones Bacterianas del Ojo/microbiología , Higiene de las Manos , Queratitis/microbiología , Contaminación de Equipos , Humanos , Inflamación/microbiología , Cooperación del Paciente , Factores de Riesgo
5.
Clin Ophthalmol ; 12: 2369-2375, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30538419

RESUMEN

The assessment of corneal staining is a commonly conducted procedure in both clinical practice and as part of various research studies. Different grading scales are employed by many clinicians and researchers to undertake this procedure for corneal staining comparisons between eyes, products and over time. This paper describes the development and use of a grading scale for corneal staining undertaken at an academic research site. The scale involves assessment of three factors across five corneal zones: type, area and depth. Staining type and area are graded on a 0-100 scale, and depth is graded on a 0-4 scale. These factors can be combined to create a three- or two-factor staining grade, or the factors may be reported individually. An additional benefit of this scale is that the staining scores may be reported by zone as "zone staining scores" or the scores of zones may be combined to provide an overall corneal "global staining score".

6.
Invest Ophthalmol Vis Sci ; 59(6): 2576-2585, 2018 05 01.
Artículo en Inglés | MEDLINE | ID: mdl-29847665

RESUMEN

Purpose: To model between subject variability of corneal swelling (CS) and deswelling after overnight wear of silicone hydrogel (SiHy) contact lenses. Methods: A total of 29 neophyte subjects wore 12 SiHy lenses with central transmissibility range of 31 to 211 Dk/t units on separate nights, in random order, and on one eye only. The contralateral eye served as the control. Central corneal thickness was measured using digital optical pachymetry before lens insertion, immediately after lens removal on waking, then 20, 40 minutes, 1, 2, and 3 hours later. Mixed modelling was conducted for simultaneous analysis of group and between-subject effects of CS and deswelling. Results: The best model for overnight CS versus Dk/t was linear with a random intercept showing constant between-subject differences in CS for different Dk/t values. The best fit for corneal deswelling versus time was a curvilinear random intercept and random slope model. About 90% of the total between-subject deswelling variance in either lens or control eyes was due to the intercept variability with much less (∼10%) being due to the variability of the individual deswelling rate (slope). Subject age, sex, and ametropia were not predictors of individual corneal swelling in the swelling versus Dk/t analysis. Age, however, was a significant (inverse) predictor of the rate of corneal deswelling, only in lens-wearing eyes. Conclusions: A large proportion of variability in corneal swelling is because of subject-specific differences in corneal response to hypoxia. This shows that "low swellers" and "high swellers" actually do exist.


Asunto(s)
Lentes de Contacto Hidrofílicos/efectos adversos , Córnea/fisiopatología , Edema Corneal/etiología , Edema Corneal/fisiopatología , Modelos Biológicos , Siliconas , Adolescente , Adulto , Lentes de Contacto de Uso Prolongado/efectos adversos , Método Doble Ciego , Femenino , Humanos , Hidrogeles , Masculino , Persona de Mediana Edad , Adulto Joven
7.
Eye (Lond) ; 32(6): 1042-1047, 2018 06.
Artículo en Inglés | MEDLINE | ID: mdl-29391573

RESUMEN

PURPOSE: A pilot study to determine the prevalence of myopia, proportion of uncorrected myopia and pertinent environmental factors among children in a suburban region in Canada. METHODS: Refraction with cycloplegia and ocular biometry were measured in children of two age groups. Myopia was considered at a spherical equivalent refraction (SER) ≤-0.50 D in at least one eye. Parents completed a questionnaire that captured the child's daily activities. RESULTS: A total of 166 children completed the study (83 aged 6-8 and 83 aged 11-13). Myopia prevalence was 17.5% among the overall group, 6.0% among ages 6-8 and 28.9% among ages 11-13. Mean subjective SER in myopic children was -1.10 D (95% confidence interval (CI), -0.34 to -1.86 D) at ages 6-8 and -2.44 D (95% CI, -1.71 to -3.18 D) at ages 11-13. In this study, 34.5% of the myopic children were uncorrected, which represented 6.0% of the entire group of children. Mean axial length (AL) increased by 1.03 mm from ages 6-8 (mean 22.62 mm; 95% CI, 22.45 to 22.79 mm) to ages 11-13 (mean 23.65 mm; 95% CI, 23.45 to 23.84 mm; p < 0.01). The correlation coefficient between AL and SER was -0.618 (p < 0.01). Binary logistic regression between outdoor time and the prevalence of myopia showed that one additional hour of outdoor time per week lowered the odds of a child having myopia by 14.3% (p = 0.007). CONCLUSION: Myopia prevalence increased from 6% at ages 6-8 to 29% at ages 11-13. Thirty-five per cent of the myopes in this study were uncorrected. More time outdoors may be beneficial to protect against myopia onset.


Asunto(s)
Miopía/epidemiología , Adolescente , Longitud Axial del Ojo , Canadá/epidemiología , Niño , Estudios Transversales , Femenino , Humanos , Modelos Logísticos , Masculino , Proyectos Piloto , Prevalencia
8.
Ophthalmic Physiol Opt ; 36(6): 643-648, 2016 11.
Artículo en Inglés | MEDLINE | ID: mdl-27790772

RESUMEN

PURPOSE: Contact lens discomfort continues to be reported as the primary reason for soft lens discontinuation, regardless of new modalities and materials. The purpose of this analysis of comfort related data from a series of clinical studies was to review whether there was a difference between symptomatic and asymptomatic habitual lens wearers' comfort responses over the course of the day. METHODS: Data from five independent non-dispensing clinical studies were pooled and analysed. Participants in these studies were assigned to one of two groups depending on whether they were classified as symptomatic or asymptomatic contact lens wearers according to a modified Subjective Evaluation of Symptoms of Dryness (SESOD) questionnaire. Masked participants were randomised to wear either a hydrogel or a silicone hydrogel contact lens and their ocular comfort was rated using a visual analogue scale on insertion and 2-hourly during an 8-hour period of a single lens wearing day. RESULTS: Data from 103 participants were used, 58 in the symptomatic group and 45 in the asymptomatic group as determined by the SESOD questionnaire. There was no effect of lens material on comfort (p = 0.43). However, there was a significant interaction between symptoms and time. The difference in mean comfort between the symptomatic and asymptomatic group was significant at each time point (p < 0.05). However, comfort did not vary significantly over the day for the asymptomatic group (p = 0.87), whereas, there was a significant decline in mean comfort ratings for the symptomatic group from 84.6 ± 13.2 (S.D.) at insertion to 73.0 ± 18.5 at 8 hours (p < 0.001). CONCLUSIONS: In our study, changes in contact lens comfort over a day were independent of lens material but not symptoms. Symptomatic lens wearers reported a progressive decrease in comfort, whereas asymptomatic wearers did not. Therefore, asymptomatic wearers should not be used when measuring contact lens comfort in clinical studies. The exclusion of asymptomatic lens wearers would likely increase the sensitivity of comfort ratings as a measure in contact lens research.


Asunto(s)
Lentes de Contacto Hidrofílicos/psicología , Hábitos , Satisfacción del Paciente , Errores de Refracción/terapia , Encuestas y Cuestionarios , Femenino , Estudios de Seguimiento , Humanos , Masculino , Factores de Tiempo , Visión Ocular
9.
Optom Vis Sci ; 93(8): 828-35, 2016 08.
Artículo en Inglés | MEDLINE | ID: mdl-27232895

RESUMEN

PURPOSE: To explore the effect of masking on subjective responses when wearing daily disposable (DD) contact lenses. METHODS: In an adaptation phase, habitual wearers of Manufacturer-A (MFA) (n = 43) and Manufacturer-B (MFB) (n = 53) wore MFA-brand 1 or MFB-brand 1 DDs, respectively, for 30 days, open-label. Subjects were then randomly assigned to one of two experiments. Each experiment included two, 3-day crossover phases. An enhanced version of MFA and MFB lenses (MFA-brand 2 and MFB-brand 2) were worn contralaterally to evaluate potential differences in masking result between manufacturers. Experiment 1: subjects were fully masked to lens and packaging (FM) then unmasked (UM). Experiment 2: subjects were FM then partially masked using an over-label (PM). Comfort ratings (0-100) were recorded for each lens daily and preference between lenses was recorded on day 3 for each crossover phase. The mean difference between 0-100 ratings or preference when FM or PM versus UM for the same lens was considered a measurement of the effect associated with masking. The purpose of the study was withheld from subjects to minimize bias. RESULTS: The effect associated with masking for habitual wearers of MFA and MFB lenses was less than 1 out of 100 (0 ± 2.5) in both experiments. Fifty-eight subjects (60%) expressed no preference when FM. This decreased to 29 (30%) when UM or PM (proportion test, p < 0.001). Approximately half the subjects had a change in lens preference when they were UM or PM, primarily in favor of their habitual lens manufacturer. CONCLUSIONS: Masking did not have a measurable impact on 0-100 ratings with the DD lenses used in this study but did have an impact on lens preference. Subjects were more likely to express a preference when they handled the lenses and were exposed to the lens packaging and, in some cases, able to read the lens brand and lens manufacturer.


Asunto(s)
Lentes de Contacto Hidrofílicos/estadística & datos numéricos , Anonimización de la Información , Equipos Desechables , Comodidad del Paciente , Satisfacción del Paciente , Adaptación Ocular , Adolescente , Adulto , Lentes de Contacto , Estudios Cruzados , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prioridad del Paciente , Adulto Joven
12.
J. optom. (Internet) ; 8(1): 19-26, ene.-mar. 2015. tab, graf
Artículo en Inglés | IBECS | ID: ibc-137663

RESUMEN

Purpose: To compare central corneal swelling after eight hours of sleep in eyes wearing four different silicone hydrogel lenses with three different powers. Methods: Twenty-nine neophyte subjects wore lotrafilcon A (Dk, 140), balafilcon A (Dk, 91), galyfilcon A (Dk, 60) and senofilcon A (Dk, 103) lenses in powers −3.00, −10.00 and +6.00 D on separate nights, in random order, and on one eye only. The contra-lateral eye (no lens) served as the control. Central corneal thickness was measured using a digital optical pachometer before lens insertion and immediately after lens removal on waking. Results: For the +6.00 D and −10.00 D, lotrafilcon A induced the least swelling and galyfilcon A the most. The +6.00 D power, averaged across lens materials, induced significantly greater central swelling than the −10.00 and −3.00 D (Re-ANOVA, p < 0.001), (7.7 ± 2.9% vs. 6.8 ± 2.8% and 6.5 ± 2.5% respectively) but there was no difference between −10.00 and −3.00 D. Averaged for power, lotrafilcon A induced the least (6.2 ± 2.8%) and galyfilcon A the most (7.6 ± 3.0%) swelling at the center (Re-ANOVA, p < 0.001). Central corneal swelling with +6.00 D was significantly greater than −10.00 D lens power despite similar levels of average lens transmissibility of these two lens powers. Conclusions: The differences in corneal swelling of the lens wearing eyes are consistent with the differences in oxygen transmission of the silicone hydrogel lenses. In silicone hydrogel lenses central corneal swelling is mainly driven by central lens oxygen transmissibility (AU)


Objetivo: Comparar el edema central de la córnea tras ocho horas de sueño, en ojos con cuatro lentes diferentes de hidrogel de silicona de tres potencias diferentes. Métodos: Veintinueve pacientes no usuarios de lentes de contacto llevaron lentes de lotrafilcon A (Dk, 140), balafilcon A (Dk, 91), galyfilcon A (Dk, 60) y senofilcon A (Dk, 103) con potencias de −3,00, −10,00 y +6.00 D durante noches diferentes, en orden aleatorio, y en un solo ojo. El ojo contra-lateral (sin lente) se utilizó como control. El espesor central de la córnea se midió utilizando un paquímetro óptico digital antes de la inserción e inmediatamente tras la retirada de la lente al despertar. Resultados: Para +6,00 D y −10,00 D, lotrafilcon A produjo el menor edema, comparado con galyfilcon A. La potencia +6,00 D, promediada en los materiales de las lentes, produjo un edema central considerablemente mayor que las potencias −10,00 y −3,00 D (Re-ANOVA, p < 0,001), (7,7 ± 2,9% frente a 6,8 ± 2,8% y 6,5 ± 2,5% respectivamente), pero no existió diferencia entre −10,00 y −3,00 D. Promediando las potencias para cada lente, lotrafilcon A produjo el menor edema en el centro (6,2 ± 2,8%) y galyfilcon A la mayor (7,6 ± 3,0%) (Re-ANOVA, p < 0,001). El edema corneal central con +6,00 D fue considerablemente superior que la de la potencia de lente −10,00 D, a pesar de los niveles similares de transmisibilidad media de la lente de estas dos potencias. Conclusiones: Las diferencias en cuanto a edema de la córnea de los ojos portadores de lentes son consistentes con las diferencias en cuanto a transmisión del oxígeno de las lentes de hidrogel de silicona. En las lentes de hidrogel de silicona, el edema corneal central es principalmente debido a la transmisibilidad del oxígeno central de la lente (AU)


Asunto(s)
Humanos , Lentes de Contacto Hidrofílicos/efectos adversos , Edema Corneal/etiología , Transferencia de Oxígeno/análisis , Paquimetría Corneal/métodos , Topografía de la Córnea
13.
J Optom ; 8(1): 19-26, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25649637

RESUMEN

PURPOSE: To compare central corneal swelling after eight hours of sleep in eyes wearing four different silicone hydrogel lenses with three different powers. METHODS: Twenty-nine neophyte subjects wore lotrafilcon A (Dk, 140), balafilcon A (Dk, 91), galyfilcon A (Dk, 60) and senofilcon A (Dk, 103) lenses in powers -3.00, -10.00 and +6.00 D on separate nights, in random order, and on one eye only. The contra-lateral eye (no lens) served as the control. Central corneal thickness was measured using a digital optical pachometer before lens insertion and immediately after lens removal on waking. RESULTS: For the +6.00 D and -10.00 D, lotrafilcon A induced the least swelling and galyfilcon A the most. The +6.00 D power, averaged across lens materials, induced significantly greater central swelling than the -10.00 and -3.00 D (Re-ANOVA, p<0.001), (7.7±2.9% vs. 6.8±2.8% and 6.5±2.5% respectively) but there was no difference between -10.00 and -3.00 D. Averaged for power, lotrafilcon A induced the least (6.2±2.8%) and galyfilcon A the most (7.6±3.0%) swelling at the center (Re-ANOVA, p<0.001). Central corneal swelling with +6.00 D was significantly greater than -10.00 D lens power despite similar levels of average lens transmissibility of these two lens powers. CONCLUSIONS: The differences in corneal swelling of the lens wearing eyes are consistent with the differences in oxygen transmission of the silicone hydrogel lenses. In silicone hydrogel lenses central corneal swelling is mainly driven by central lens oxygen transmissibility.


Asunto(s)
Lentes de Contacto de Uso Prolongado/efectos adversos , Lentes de Contacto Hidrofílicos/efectos adversos , Edema Corneal/etiología , Hidrogeles , Elastómeros de Silicona , Adolescente , Adulto , Análisis de Varianza , Edema Corneal/patología , Femenino , Humanos , Hidrogeles/efectos adversos , Masculino , Persona de Mediana Edad , Elastómeros de Silicona/efectos adversos , Adulto Joven
14.
Optom Vis Sci ; 92(3): 301-11, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-25628269

RESUMEN

PURPOSE: To determine the clinical performance of DAILIES TOTAL1 (DT1), Clariti 1Day (C1D), and 1-DAY ACUVUE TruEye (AVTE) silicone hydrogel daily disposable contact lenses (SiHy DDCLs). METHODS: Eligible participants, subdivided into asymptomatic and symptomatic groups, wore each SiHy DDCLs for three consecutive days. Each participant attended three visits (on day 1 at 0 hours; on days 1 and 3 after 8 hours of wear) per lens type. The order of lens wear was randomized, with at least 1 day washout between lenses. Lens-related performance was evaluated by assessing lens surface deposits, wettability, pre-lens noninvasive tear breakup time, lens movement, and centration; ocular response assessments included conjunctival redness, corneal staining, and conjunctival staining and indentation. RESULTS: Fifty-one asymptomatic and 53 symptomatic participants completed the study. For all visits, the mean noninvasive tear breakup time was about 1 second longer with DT1 than with C1D and AVTE (p < 0.01). Overall, the wettability of all three lenses was good; however, DT1 was graded marginally better than the other lenses (both p < 0.01). On day 3, eyes wearing AVTE had significantly more dehydration-induced corneal staining compared with DT1 (AVTE, 24%; DT1, 11%; p < 0.01). After 8 hours, conjunctival staining was different between lenses (greatest with C1D and least with DT1; all p < 0.01). Conjunctival indentation was more prevalent with the C1D lenses (n = 70) compared with DT1 (n = 1; p < 0.01) and AVTE (n = 11; p < 0.01). There were no differences between asymptomatic and symptomatic lens wearers for any of the clinical parameters (all p > 0.05). CONCLUSIONS: Each of the three SiHy DDCLs performed well. Noninvasive tear breakup time was longest and wettability was greater with DT1. C1D had the most conjunctival staining conjunctival indentation. There was no difference between asymptomatic and symptomatic wearers with regard to ocular response and contact lens-related parameters. These results suggest that SiHy DDCLs may be an excellent contact lens modality for the symptomatic patient.


Asunto(s)
Lentes de Contacto Hidrofílicos , Hidrogel de Polietilenoglicol-Dimetacrilato , Satisfacción del Paciente , Elastómeros de Silicona , Adolescente , Adulto , Estudios Cruzados , Equipos Desechables , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Ajuste de Prótesis , Método Simple Ciego , Lágrimas/química , Agudeza Visual/fisiología , Humectabilidad , Adulto Joven
15.
Optom Vis Sci ; 92(2): 175-82, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25525891

RESUMEN

PURPOSE: To compare subjective and objective visual performance of the Air Optix Aqua Multifocal lens to monovision in a group of subjects requiring a medium level of reading-addition power. METHODS: Fifty participants with reading additions between 1.25 and 2.00 diopters (inclusive) were randomized into a prospective, crossover clinical trial. They wore monovision and multifocals for 2 weeks in a randomized order. High- and low-contrast logMAR (logarithm of the minimum angle of resolution) acuity and stereopsis were measured at the beginning and end of each period. During each phase, participants performed specific tasks followed by subjective rating surveys and also completed satisfaction rating surveys on days 3, 7, and 12; all were transferred in real time using BlackBerry smartphones. A general rating survey was completed at the dispensing and 2-week visits. RESULTS: Forty-nine participants completed the study (mean age, 52 years). Distance and near high- and low-contrast acuities were significantly better (p < 0.05) with monovision at all visits. High-contrast intermediate acuity was only better (p < 0.05) with multifocals after 2 weeks. Stereopsis was equivalent after 2 weeks, but better (p < 0.05) with multifocals at dispensing. Subjective ratings were generally equivalent between modalities although there was a trend for multifocals to be rated higher for focus changing and driving, whereas monovision tended to be rated higher for near tasks. For both corrections, the satisfaction survey showed no significant change between days 3, 7, and 12, and the general survey showed that comfort was maintained but subjective vision ratings decreased significantly over the 2 weeks. Twenty-five participants (51%) preferred multifocals, 18 (37%) preferred monovision, and the remaining 6 (12%) declared both unacceptable. CONCLUSIONS: In this cohort, distance and near acuities were better with monovision, whereas the subjective ratings tended to favor the Air Optix Aqua Multifocal, with the exception of near performance. Preference was statistically similar between both corrections, with a trend toward preferring the multifocal.


Asunto(s)
Lentes de Contacto Hidrofílicos , Percepción de Profundidad/fisiología , Hiperopía/terapia , Miopía/terapia , Presbiopía/terapia , Visión Binocular/fisiología , Agudeza Visual/fisiología , Adulto , Anciano , Estudios Cruzados , Diseño de Equipo , Femenino , Humanos , Hiperopía/fisiopatología , Masculino , Persona de Mediana Edad , Miopía/fisiopatología , Satisfacción del Paciente , Presbiopía/fisiopatología , Estudios Prospectivos , Encuestas y Cuestionarios
16.
Curr Eye Res ; 39(3): 245-56, 2014 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-24143910

RESUMEN

PURPOSE: A pilot study was conducted to evaluate human corneal epithelial cell shedding in response to wearing a silicone hydrogel contact lens/solution combination inducing corneal staining. The nature of ex vivo collected cells staining with fluorescein was also examined. METHODS: A contralateral eye study was conducted in which up to eight participants were unilaterally exposed to a multipurpose contact lens solution/silicone hydrogel lens combination previously shown to induce corneal staining (renu® fresh™ and balafilcon A; test eye), with the other eye using a combination of balafilcon A soaked in a hydrogen peroxide care system (Clear Care®; control eye). Lenses were worn for 2, 4 or 6 hours. Corneal staining was graded after lens removal. The Ocular Surface Cell Collection Apparatus was used to collect cells from the cornea and the contact lens. RESULTS: In the test eye, maximum solution-induced corneal staining (SICS) was observed after 2 hours of lens wear (reducing significantly by 4 hours; p < 0.001). There were significantly more cells collected from the test eye after 4 hours of lens wear when compared to the control eye and the collection from the test eye after 2 hours (for both; n = 5; p < 0.001). The total cell yield at 4 hours was 813 ± 333 and 455 ± 218 for the test and control eyes, respectively (N = 5, triplicate, p = 0.003). A number of cells were observed to have taken up the fluorescein dye from the initial fluorescein instillation. Confocal microscopy of fluorescein-stained cells revealed that fluorescein was present throughout the cell cytoplasm and was retained in the cells for many hours after recovery from the corneal surface. CONCLUSION: This pilot study indicates that increased epithelial cell shedding was associated with a lens-solution combination which induces SICS. Our data provides insight into the transient nature of the SICS reaction and the nature of fluorescein staining observed in SICS.


Asunto(s)
Soluciones para Lentes de Contacto/efectos adversos , Lentes de Contacto Hidrofílicos/efectos adversos , Epitelio Corneal/efectos de los fármacos , Epitelio Corneal/patología , Geles de Silicona/efectos adversos , Adulto , Antiinfecciosos Locales/administración & dosificación , Antiinfecciosos Locales/efectos adversos , Soluciones para Lentes de Contacto/administración & dosificación , Método Doble Ciego , Fluoresceína , Colorantes Fluorescentes , Humanos , Hidrogel de Polietilenoglicol-Dimetacrilato/efectos adversos , Peróxido de Hidrógeno/administración & dosificación , Peróxido de Hidrógeno/efectos adversos , Persona de Mediana Edad , Proyectos Piloto , Estudios Prospectivos , Adulto Joven
18.
Optom Vis Sci ; 90(9): 945-53, 2013 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23892493

RESUMEN

PURPOSE: To evaluate subjective ocular comfort across the day with three silicone hydrogel daily disposables (SHDDs) in a group of adapted lens wearers. METHODS: Masked subjects (asymptomatic or symptomatic of end-of-day (EOD) dryness with habitual lenses) wore three SHDDs: DAILIES TOTAL1 (DT1), Clariti 1day (C1D), or 1-DAY ACUVUE TRUEYE (AVTE), each for 3 days. On day 2, wearing time (WT) and comfort ratings after insertion, at 4, 8, and 12 hours, and at EOD were recorded. Because not all subjects wore lenses for 12 hours, comfort was analyzed across the day (up to 8 hours, 8 to 12 hours), and a new variable ("cumulative comfort" [CC]) was calculated for EOD. RESULTS: One hundred four subjects completed the study (51 asymptomatic, 53 symptomatic). The two groups had different WTs (mean WT, 14.0 and 12.7 hours, respectively; p < 0.001). Ocular comfort was rated higher in the asymptomatic group throughout the day (p < 0.001). One hundred four subjects wore all three SHDDs for at least 8 hours, whereas 74 (45 asymptomatic, 29 symptomatic) subjects wore them for 12 hours or longer. Comfort ratings were higher with DT1 (least square means [LSM] = 91.0) than with C1D (LSM = 86.5; p < 0.001) and AVTE (LSM = 87.7; p = 0.011) for the first 8 hours and lower with C1D compared with DT1 (p = 0.012) from 8 to 12 hours. Mean EOD (± SD) comfort with the C1D lens was 72 ± 21, lower than both DT1 (mean, 79 ± 17; p = 0.001) and AVTE (mean, 78 ± 21; p = 0.010). Mean CC was higher in the asymptomatic group (mean, 1261 ± 59) compared with that in the symptomatic group (mean, 1009 ± 58; p < 0.001) and higher for DT1 (mean, 1184 ± 258) than C1D (mean, 1094 ± 318; p = 0.002) and AVTE (mean, 1122 ± 297; p = 0.046). CONCLUSIONS: All three SHDDs had average WTs of 12 hours or longer for 1 day. Comfort during the first 12 hours was highest with DT1 (similar to AVTE between 8 and 12 hours) and lowest with C1D. End-of-day comfort was lowest with C1D, and CC was highest for DT1. Cumulative comfort may be a valuable new metric to assess ocular comfort during the day.


Asunto(s)
Lentes de Contacto Hidrofílicos , Hidrogel de Polietilenoglicol-Dimetacrilato , Satisfacción del Paciente , Elastómeros de Silicona , Adolescente , Adulto , Córnea/fisiología , Estudios Cruzados , Equipos Desechables , Síndromes de Ojo Seco/fisiopatología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Errores de Refracción/terapia , Método Simple Ciego , Visión Ocular/fisiología , Adulto Joven
20.
Ophthalmic Epidemiol ; 20(3): 123-30, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-23713914

RESUMEN

PURPOSE: The prevalence of visual impairment due to uncorrected refractive error has not been previously studied in Canada. A population-based study was conducted in Brantford, Ontario. METHODS: The target population included all people 40 years of age and older. Study participants were selected using a randomized sampling strategy based on postal codes. Presenting distance and near visual acuities were measured with habitual spectacle correction, if any, in place. Best corrected visual acuities were determined for all participants who had a presenting distance visual acuity of less than 20/25. RESULTS: Population weighted prevalence of distance visual impairment (visual acuity <20/40 in the better eye) was 2.7% (n = 768, 95% confidence interval (CI) 1.8-4.0%) with 71.8% correctable by refraction. Population weighted prevalence of near visual impairment (visual acuity <20/40 with both eyes) was 2.2% (95% CI 1.4-3.6) with 69.1% correctable by refraction. Multivariable adjusted analysis showed that the odds of having distance visual impairment was independently associated with increased age (odds ratio, OR, 3.56, 95% CI 1.22-10.35; ≥65 years compared to those 39-64 years), and time since last eye examination (OR 4.93, 95% CI 1.19-20.32; ≥5 years compared to ≤2 years). The same factors appear to be associated with increased prevalence of near visual impairment but were not statistically significant. CONCLUSIONS: The majority of visual impairment found in Brantford was due to uncorrected refractive error. Factors that increased the prevalence of visual impairment were the same for distance and near visual acuity measurements.


Asunto(s)
Errores de Refracción/epidemiología , Población Urbana/estadística & datos numéricos , Trastornos de la Visión/epidemiología , Personas con Daño Visual/estadística & datos numéricos , Adulto , Distribución por Edad , Anciano , Anciano de 80 o más Años , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Oportunidad Relativa , Ontario/epidemiología , Prevalencia , Errores de Refracción/terapia , Factores de Riesgo , Distribución por Sexo , Agudeza Visual/fisiología
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