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OBJECTIVES: The Global Activity Limitation Indicator (GALI) is an instrument that measures long-term overall disability. The objective of this study was to evaluate GALI's predictive value on mortality while examining variations according to sex, age, and educational level. STUDY DESIGN: Longitudinal study. METHODS: This longitudinal study was based on 42,991 individuals aged ≥15 years who participated in the 2011-2012 National Health Survey and the 2014 European Health Survey in Spain. These records were linked to mortality data up to December 2021. GALI assessed self-reported functional limitation in the past 6 months and classified individuals into three categories: severely limited, limited but not severely, and not limited. Incidence rate ratios (IRR) were calculated using Poisson regression models, adjusting for sociodemographic, lifestyle, and health status variables. RESULTS: Compared to individuals with no limitations, those with non-severe limitations had an IRR for mortality of 1.27 (95% CI: 1.16-1.38), and 2.04 (95% CI: 1.81-2.31) in those with severe limitations. Women with severe limitations exhibited a higher IRR (2.32; 95% CI: 1.98-2.71) compared to men (1.73; 95% CI: 1.45-2.08) (P for interaction = 0.005). Individuals <65 years with severe limitations showed a greater association (2.22; 95% CI: 1.58-3.10) than those ≥65 (1.49; 95% CI: 1.32-1.69) (P for interaction <0.001). Among individuals with lower educational attainment, the IRR was 2.08 (95% CI: 1.83-2.37), and 1.87 (95% CI: 1.37-2.56) for the higher education group (P for interaction = 0.017). CONCLUSIONS: GALI is a robust predictor of all-cause mortality in the general population and subgroups. The association is stronger in women, individuals <65 years, and those with lower educational levels.
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Personas con Discapacidad , Indicadores de Salud , Masculino , Humanos , Femenino , Estudios Longitudinales , Estado de Salud , Encuestas EpidemiológicasRESUMEN
Introducción y objetivos: Estimar la mortalidad atribuida (MA) al consumo de tabaco en las comunidades autónomas (CCAA) de España en población de edad ≥ 35 años en 2017. Métodos: Se estimó la MA empleando un método dependiente de prevalencias basado en el cálculo de fracciones atribuidas poblacionales. La mortalidad observada procede del Instituto Nacional de Estadística; las prevalencias de consumo por sexo y edad, de la Encuesta Nacional de Salud de 2011 y 2017 y la Encuesta europea de 2014, y los riesgos relativos, del seguimiento de 5 cohortes norteamericanas. Se presentan estimaciones de MA y fracciones atribuidas poblacionales para cada comunidad autónoma por causa de muerte, sexo y edad y tasas de MA específicas y ajustadas. Resultados: El tabaco causó 53.825 muertes en España en la población de 35 o más años (el 12,9% de la mortalidad total). La carga de MA sobre la mortalidad observada varía del 10,8% en La Rioja al 15,3% en Canarias. Tras ajustar las tasas de MA por edad, las diferencias entre CCAA se mantienen, y las tasas más altas en los varones se observan en Extremadura y en las mujeres, en Canarias. Las tasas ajustadas de los varones se correlacionan negativamente con las de las mujeres. El porcentaje que suponen las enfermedades cardiovasculares sobre la MA total de cada comunidad autónoma oscila entre el 21,8% de Castilla-La Mancha y el 30,3% de Andalucía. Conclusiones: La carga de MA al consumo de tabaco varía entre las CCAA. Realizar un análisis detallado por regiones aporta información relevante para la implantación de políticas sanitarias dirigidas a frenar el impacto del tabaquismo (AU)
Introduction and objectives: To estimate smoking-attributable mortality (SAM) in the regions of Spain among people aged ≥ 35 years in 2017. Methods: SAM was estimated using a prevalence dependent method based calculating the population attributable fraction. Observed mortality was derived from the National Statistics Institute. The prevalence of smoking by age and sex was based on the Spanish National Health Survey for 2011 and 2017 and the European Survey for 2014. Relative risks were reported from the follow-up of 5 North American cohorts. SAM and population attributable fraction were estimated for each region by age group, sex, and causes of death. Cause-specific and adjusted SAM rates were estimated. Results: Smoking caused 53 825 deaths in the population aged ≥ 35 years (12.9% of all-cause mortality). SAM ranged from 10.8% of observed mortality in La Rioja to 15.3% in the Canary Islands. The differences remained after rates were adjusted by age. The highest adjusted SAM rates were observed in Extremadura in men and in the Canary Islands in women. Adjusted SAM rates in men were inversely correlated with those in women. The percentage of total SAM represented by cardiovascular diseases in each region ranged from 21.8% in Castile-La Mancha to 30.3% in Andalusia. Conclusions: The distribution of SAM differed among regions. Conducting a detailed region-by-region analysis provides relevant information for health policies aiming to curb the impact of smoking (AU)
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Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Tabaquismo/mortalidad , Enfermedades Cardiovasculares/mortalidad , España/epidemiología , Encuestas Epidemiológicas , PrevalenciaRESUMEN
BACKGROUND AND OBJECTIVE: Changes in infant morbidity require adaptations to preserve their proper development and academic performance. The objective of this study was to know the perceived needs of teachers, pediatricians and pediatric nurses regarding the training of schools to deal with emergences related to chronic pathology and accidents. METHOD: Cross-sectional study using an ad hoc validated questionnaire on digital support (Google Forms) that included sociodemographic variables and a structured survey that collected information on chronic pathology, health care and safety in case of emergency in the school. RESULTS: Data from 266 questionnaires (134 teachers, 132 pediatricians and pediatric nurses) were analyzed. 73.9% of the teachers stated that they have had students with chronic pathology during the last year and 45.5% confirmed the existence of protocols for their assistance, although 68.7% did not receive specific training for their care. 25% of pediatricians and nurses stated that the parents of children with chronic disease always notify the schools and 17.4% stated that they knew about the existence of specific protocols. 35.6% collaborated in training related to specific pathology or emergencies in schools, with a greater predominance of primary health care (P<.001). 50.7% of the pediatricians and 79.7% of the nurses stated as a medium-high priority the need to have a school nurse in the centers. CONCLUSIONS: The health care of students with chronic diseases in schools can be improved for teachers, pediatricians and pediatric nurses, considering the figure of school nurse as the main improvement measure.
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Padres , Instituciones Académicas , Niño , Enfermedad Crónica , Estudios Transversales , Atención a la Salud , Humanos , Lactante , Encuestas y CuestionariosRESUMEN
Objetivo Describir, mediante pruebas funcionales y biomecánicas, cómo la intervención personalizada de fisioterapia acuática puede contribuir a mejorar la marcha y funcionalidad en un paciente con accidente cerebrovascular crónico. Descripción del caso Mujer de 63 años que experimentó un accidente cerebrovascular en 2006. Presentaba hemiplejía del miembro superior izquierdo y hemiparesia del miembro inferior izquierdo, que limitaban su marcha y funcionalidad. Se evaluaron la fuerza muscular isométrica, la percepción del esfuerzo para actividades de la vida diaria, la marcha mediante pruebas funcionales y el centro de presiones, utilizando una plataforma de fuerzas. Intervención Dos sesiones de terapia acuática a la semana, durante 8 semanas, basadas en la terapia acuática específica Halliwick ®, el método de los anillos de Bad Ragaz ® y en entrenamiento de marcha con peso y dobles tareas. Resultados La percepción del esfuerzo al caminar disminuyó 30mm, la prueba Timed Up and Go disminuyó 5,88 segundos, la fuerza muscular aumentó más de 4kg en todos los músculos, excepto flexores de cadera y extensores de rodilla, y el desplazamiento del centro de presiones disminuyó en todos los planos y tareas evaluadas. Conclusión Este estudio respalda la idea de que la terapia acuática puede contribuir a mejorar aspectos biomecánicos que ayudan a explicar las mejoras clínicas en pacientes con accidente cerebrovascular (AU)
Objective To describe, through functional and biomechanical tests, how a personalized aquatic physiotherapy intervention can contribute to improving gait and functionality in a patient with chronic stroke. Description of the case Woman with 63-year-old who suffered a stroke in 2006. She presents hemiplegia of the left upper limb and hemiparesis of the left lower limb, which limit her gait and functionality. Isometric muscle strength, perception of effort for activities of daily living, gait through functional tests, and center of pressure displacement were evaluated using a force platform. Intervention Two aquatic therapy sessions per week, for 8 weeks, based on Specific Aquatic Therapy-Halliwick ®, Bad Ragaz ® Ring Method and dual task weight gait training. Results Perception of effort when walking decreased 30mm, Timed-Up-and-Go decreased by 5.88seconds, muscle strength increased more than 4kg in all muscles, except hip flexors and knee extensors, and center of pressure displacement decreased in all the plans and tasks evaluated. Conclusion This study supports the idea that aquatic therapy can contribute to improving biomechanical aspects that can have an impact on clinical improvements in stroke patients (AU)
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Humanos , Femenino , Persona de Mediana Edad , Rehabilitación de Accidente Cerebrovascular/métodos , Terapia por Ejercicio/métodos , Natación , Marcha , Resultado del TratamientoRESUMEN
BACKGROUND AND OBJECTIVES: Despite the biological plausibility of the association between heavy metal exposure and mental health disorders, epidemiological evidence remains scarce. The objective was to estimate the association between heavy metals and metalloids in soil and the prevalence of mental disorders in the adult population of Spain. METHODS: Individual data came from the Spanish National Health Survey 2011-2012, 18,073 individuals residing in 1772 census sections. Mental health was measured with the 12-item General Health Questionnaire. The concentration estimates of heavy metal and metalloid levels in topsoil (upper soil horizon) came from the Geochemical Atlas of Spain based on 13,317 soil samples. Levels of lead (Pb), arsenic (As), cadmium (Cd) and manganese (Mn) were estimated in each census section by "ordinary Kriging". Odds ratios (OR) were calculated by multilevel logistic regression models. RESULTS: Compared with the lowest Pb concentration levels quartile, the OR for the second quartile was 1.29 (95%CI: 1.11-1.50), increasing progressively to 1.37 (95%CI: 1.17-1.60) and 1.51 (95%CI: 1.27-1.79) in the third and fourth quartiles, respectively. For As, the association was observed in the third and fourth quartiles: 1.21 (95%CI: 1.04-1.41) and 1.42 (95% CI: 1.21-1.65), respectively. Cd was associated also following a gradient from the second quartile: 1.34 (95%CI: 1.15-1.57) through the fourth: 1.84 (95%CI: 1.56-2.15). In contrast, Mn only showed a positive association at the second quartile. Additionally, individuals consuming vegetablesâ¯>â¯once a day the OR for the fourth quartile of Pb concentration, vs. the first, increased to 2.93 (95%CI: 1.97-4.36); similarly for As: 3.00 (95%CI: 2.08-4.31), and for Cd: 3.49 (95%CI: 2.33-5.22). CONCLUSIONS: Living in areas with a higher concentration of heavy metals and metalloids in soil was associated with an increased probability of having a mental disorder. These relationships were strengthened in individuals reporting consuming vegetablesâ¯>â¯once a day.
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Exposición a Riesgos Ambientales/estadística & datos numéricos , Trastornos Mentales/epidemiología , Salud Mental/estadística & datos numéricos , Metales Pesados , Contaminantes del Suelo , Adulto , Cadmio , Monitoreo del Ambiente , Humanos , Metaloides , España/epidemiologíaRESUMEN
No disponible
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Humanos , Niño , Enfermedades del Sistema Endocrino , Hipotiroidismo/diagnóstico , Atención Primaria de Salud , Endocrinología/métodos , Transexualidad , Disforia de Género , Diversidad de Género , Sociedades Médicas/normasRESUMEN
Falls are a major health problem in older adults, but their relationship with alcohol consumption in this population remains unclear. In a cohort with 2170 older adults followed up for 3.3 years, both moderate drinking and the Mediterranean drinking pattern were associated with a lower risk of falls and injurious falls. INTRODUCTION: This study aims to examine the association between certain patterns of alcohol consumption, including the Mediterranean drinking pattern (MDP), and the risk of falls in older adults. METHODS: A prospective cohort with 2170 community-dwelling individuals aged ≥60 years was recruited in Spain in 2008-2010 and followed up through 2012. At baseline, participants reported alcohol consumption and, at the end of follow-up, their falls during the previous year. The MDP was defined as moderate alcohol consumption (threshold between moderate and heavy intake was 40 g/day for men and 24 g/day for women) with preference for wine and drinking only with meals. Analyses were conducted with negative binomial or logistic regression, as appropriate, and adjusted for the main confounders. RESULTS: Compared with never drinkers, the number of falls was lower in moderate drinkers (incidence rate ratio (95% confidence interval), 0.79 (0.63-0.99)) and drinkers with MDP (0.73 (0.56-0.96)). Also, moderate drinkers and those with MDP showed a lower risk of ≥2 falls (odds ratio (95% confidence interval), 0.58 (0.38-0.88) and 0.56 (0.34-0.93), respectively) and of falls requiring medical care (0.67 (0.46-0.96) and 0.61 (0.39-0.96), respectively). CONCLUSION: Both moderate drinking and the MDP were associated with a lower risk of falls and injurious falls in older adults. However, sound advice on alcohol consumption should balance risks and benefits.
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Accidentes por Caídas/estadística & datos numéricos , Consumo de Bebidas Alcohólicas/epidemiología , Factores de Edad , Anciano , Estudios de Cohortes , Factores de Confusión Epidemiológicos , Femenino , Estudios de Seguimiento , Humanos , Estilo de Vida , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Factores de Riesgo , Factores Sexuales , España/epidemiología , Templanza/estadística & datos numéricosRESUMEN
The relation between age and mortality after hip fracture was analyzed in elderly patients. 5.5% of the 31,884 patients died. Compared to those 65-74 years old, the multivariate OR for mortality for those 75-84 and ≥85 were 2.11 (95% CI: 1.61-2.77) and 4.10 (95% CI: 3.14-5.35). PURPOSE: To analyze the impact of Elixhauser comorbidities on the relation between age and mortality after hip fracture in elderly patients. METHODS: Cross-sectional study of the population ≥65 years old hospitalized in Spain in 2013 with a diagnosis of fall-related hip fracture in the Basic Minimum Set Data (BMSD). The impact of Elixhauser comorbidities on the association between mortality and age groups (65-74, 75-84, ≥85) was analyzed by logistic regression models with progressive adjustment for demographic variables and comorbidities introduced individually. RESULTS: We identified 31,884 patients, 5.5% of which died during hospitalization. Compared with those 65-74 years old, the multivariate OR of mortality for those 75-84 and ≥85 years old decreased from 2.23 (95% CI: 1.71-2.90) and 4.57 (95% CI: 3.54-5.90) to 2.11 (95% CI: 1.61-2.77) and 4.10 (95% CI: 3.14-5.35), respectively after adjustment for comorbidities. The OR of mortality for men was 1.77 (95% CI: 1.58-1.98) compared to women. The comorbidities with higher OR for mortality were congestive heart failure (OR: 3.88; 95% CI: 3.42-4.41), metastasis (OR: 3.44; 95% CI: 2.27-5.20), fluid and electrolyte disorders (OR: 2.95; 95% CI: 2.47-3.52), coagulation deficiencies (OR: 2.87; 95% CI: 2.08-3.96), and liver disease (OR: 2.40; 95% CI: 1.82-3.17). CONCLUSIONS: The association between age and mortality after hip fracture remains after adjusting for numerous comorbidities. However, some potentially controllable disorders are associated with an increased risk for mortality, thus, improving their management could benefit survival.
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Accidentes por Caídas/mortalidad , Fracturas de Cadera/mortalidad , Fracturas Osteoporóticas/mortalidad , Factores de Edad , Anciano , Anciano de 80 o más Años , Comorbilidad , Estudios Transversales , Femenino , Fracturas de Cadera/etiología , Mortalidad Hospitalaria , Hospitalización/estadística & datos numéricos , Humanos , Masculino , Fracturas Osteoporóticas/etiología , Factores de Riesgo , España/epidemiologíaRESUMEN
Objetivo: Evaluar la eficacia de un preparado lácteo suplementado con fibra en niños con estreñimiento funcional. Material y métodos: Ensayo clínico, aleatorizado, doble ciego, controlado con placebo. Se incluyeron 19 niños de entre 4 y 12 años con criterios de Roma III para estreñimiento funcional. El grupo de intervención recibió durante 4 semanas 200 ml al día de leche con fibra, mientras los controles recibieron una ración similar de leche sin suplementar. Resultados: Tras 4 semanas no se encontraron diferencias estadísticamente significativas entre grupos respecto a la realización de al menos 3 deposiciones a la semana (88,9% en tratados frente a 100% en controles, p = 0,474), número de deposiciones semanales, consistencia de deposiciones o presencia de conductas de retención, dolor con la defecación e incontinencia fecal, o la salud autopercibida. En ambos se observó tendencia al aumento en el número de deposiciones; en el grupo de tratamiento de 3,6 ± 1,9 a 5,8 ± 2,0 deposiciones/semana (p = 0,059) y en el grupo placebo de 3,3 ± 1,3 a 5,8 ± 1,3 deposiciones/semana (p = 0,001). También disminuyó la presencia de dolor con la defecación en el grupo de tratamiento del 77,8% al 11,1% (p = 0,031) y en placebo del 80,0% al 20,0% (p = 0,031). Conclusiones: No se ha podido confirmar la eficacia de un preparado lácteo con fibra para el estreñimiento funcional infantil. Son necesarios estudios bien diseñados y de mayor tamaño muestral para determinar el papel de los suplementos de fibra en los niños con estreñimiento
Objective: To assess the effectiveness of a fibre-fortified milk in children with chronic functional constipation. Patients and methods: Randomised, double-blind, placebo-controlled clinical trial involving 19 children, 4 to 12-year-old, who were diagnosis with functional constipation according to Rome III Criteria. Intervention group received 200 ml of fibre-fortified milk daily for 4 weeks, while the other group received a similar portion of nonfortified milk. Results: At the end of the intervention there were no statistically significant differences between groups with respect to having at least three bowel movements a week (88.9% in intervention group vs. 100% in control group, p = 0.474), frequency of bowel movements, stool consistency, presence of painful defecation, retentive posturing, or fecal incontinence, or self-reported perceived health. Both groups tended to increase bowel movements. Fibre group increased from 3.6 ± 1.9 to 5.8 ± 2.0 bowel movements/week (p = 0.059), while control group increased from 3.3 ± 1.3 to 5.8 ± 1.3 bowel movements/week (p = 0.001). Presence of painful defecation decreased both in fibre group, 77.8% to 11.1% (p = 0.031), and in control group, 80.0% to 20,0% (p = 0.031). Conclusions: Effectiveness of a fibre-fortified milk was not confirmed in children with chronic functional constipation. High quality clinical trials are required to know the efficacy of fibre supplements in children with functional constipation
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Humanos , Masculino , Femenino , Preescolar , Niño , Adolescente , Productos Lácteos , Estreñimiento/dietoterapia , Fibras de la Dieta , Inulina/uso terapéutico , Método Doble Ciego , Placebos/uso terapéutico , Protocolos Clínicos , Conducta Alimentaria/fisiologíaRESUMEN
INTRODUCCIÓN: Las intervenciones sobre la obesidad infantil son una prioridad para la salud pública. El objetivo de este estudio fue evaluar la efectividad de un programa de intervención contra la obesidad en un colegio de Educación Primaria. MATERIAL Y MÉTODOS: Estudio de intervención controlado no aleatorizado en alumnos de primero a quinto cursos de Educación Primaria en 2 colegios públicos de Avilés (España). La intervención se desarrolló durante 2 cursos escolares, incluyendo talleres sobre alimentación saludable, charlas educativas, material informativo escrito y promoción de la actividad física. La variable de resultado principal fue la puntuación z del índice de masa corporal (IMC). Como variables de resultado secundarias se consideraron: prevalencia de obesidad y sobrepeso, perímetro abdominal, hábitos de dieta y actividad física. RESULTADOS: Fueron incluidos en el estudio 382 (177 niñas, 205 niños) de 526 alumnos de ambos colegios. En 340 individuos se obtuvieron datos antropométricos completos. A diferencia del grupo control, los pertenecientes al grupo de intervención disminuyeron la puntuación z del IMC desde 1,14 a 1,02 (p = 0,017), mejoraron el índice KIDMED de adhesión a la dieta mediterránea de 7,33 a 7,71 puntos (p = 0,045) y aumentaron la proporción de estudiantes con una dieta óptima del 42,6% al 52,3% (p = 0,021). No se encontraron diferencias estadísticamente significativas en la prevalencia de obesidad y sobrepeso, ni en el perímetro abdominal, entre los grupos de intervención y control. CONCLUSIONES: Este programa escolar consiguió pequeñas mejoras en el IMC y la calidad de la dieta
INTRODUCTION: Intervention for childhood obesity is a public health priority. The purpose of this study was to evaluatethe effectiveness of an elementary school-based intervention against obesity in children. MATERIAL AND METHODS: Non-randomised controlled trial was conducted on children from first to fifth grade from two public schools of Avilés (Spain). The intervention lasted for 2 school years comprising healthy diet workshops, educational chats, educational meetings, informative written material, and promotion of physical activities. Primary outcome measure was body mass index z-score. Secondary outcomes included: obesity and overweight prevalence, waist circumference, dietary habits, and physical activity. RESULTS: A total of 382 (177 girls, 205 boys) out of 526 pupils of both schools were included in the study. Complete anthropometric data were obtained in 340 of the 382 individuals. Compared to children in control group, those in intervention group decreased body mass index z-score from 1.14 to 1.02 (P=.017), and improved KIDMED score from 7.33 to 7.71 points (P=.045). The percentage of students who carried on an optimal diet increased from 42.6% to 52.3% (P=.021). There were no statistical differences in the prevalence of obesity and overweight, or in waist circumference between the intervention and control groups. CONCLUSIONS: This school-based program resulted in modest beneficial changes in body mass index and diet quality
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Adolescente , Niño , Humanos , Promoción de la Salud/organización & administración , Obesidad/prevención & control , Sobrepeso/prevención & control , Programas Gente Sana/organización & administración , Servicios de Salud Escolar/organización & administración , Evaluación de Resultados de Acciones Preventivas , Actividad Motora , Conducta Alimentaria , Estudios de Casos y Controles , Distribución por Edad y SexoRESUMEN
La cooperación internacional al desarrollo en salud infantil despierta un especial interés en el ámbito pediátrico. En los últimos decenios se han ido revelando nuevas evidencias en torno al análisis de los factores vinculados a la morbimortalidad en las primeras etapas de la vida en los países menos adelantados. Este mayor conocimiento del origen de los problemas de salud y las posibles respuestas en forma de intervenciones con impacto determina la necesidad de su divulgación entre los profesionales de Pediatría interesados. Se hacen necesarios mayores esfuerzos para profundizar en materias relacionadas con salud global infantil y favorecer el que los pediatras conozcan y participen en estos procesos. Este artículo pretende ofrecer un acercamiento pediátrico social hacia los elementos relacionados con cooperación internacional y salud infantil
The international development cooperation in child health arouses special interest in paediatric settings. In the last 10 10 years or so, new evidence has been presented on factors associated with morbidity and mortality in the first years of life in the least developed countries. This greater knowledge on the causes of health problems and possible responses in the form of interventions with impact, leads to the need to disseminate this information among concerned professional pediatricians. Serious efforts are needed to get a deeper insight into matters related to global child health and encourage pediatricians to be aware and participate in these processes. This article aims to provide a social pediatric approach towards international cooperation and child health-related matters
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Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Salud Infantil , Cooperación Internacional , Salud Global , Trastornos de la Nutrición del Lactante/epidemiología , Mortalidad InfantilRESUMEN
The international development cooperation in child health arouses special interest in paediatric settings. In the last 10 10 years or so, new evidence has been presented on factors associated with morbidity and mortality in the first years of life in the least developed countries. This greater knowledge on the causes of health problems and possible responses in the form of interventions with impact, leads to the need to disseminate this information among concerned professional pediatricians. Serious efforts are needed to get a deeper insight into matters related to global child health and encourage pediatricians to be aware and participate in these processes. This article aims to provide a social pediatric approach towards international cooperation and child health-related matters.
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Salud Infantil , Cooperación Internacional , Pediatría , Adolescente , Niño , Preescolar , Salud Global , Humanos , Lactante , Recién NacidoRESUMEN
We aimed to single out multiple sclerosis (MS) cases with poor outcome after natalizumab withdrawal and to identify predictive variables. We ascertained 47 withdrawals, and compared their pre- and post-natalizumab periods. We objectively defined significant clinical worsening after natalizumab withdrawal as a 2-step increase in Expanded Disability Status Scale (EDSS). We performed regression models. As a group, post-natalizumab annualized relapse rate (ARR) was lower in the post-natalizumab period, and there were no differences in the mean number of gadolinium (Gd)-enhancing lesions between pre- and post-natalizumab magnetic resonance imaging (MRI). Corticosteroid treatment did not change the outcomes. Eight patients (19%) presented significant clinical worsening after natalizumab withdrawal, which was predicted by a higher baseline EDSS and a 1-step EDSS increase while on natalizumab.
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Progresión de la Enfermedad , Factores Inmunológicos/uso terapéutico , Esclerosis Múltiple/tratamiento farmacológico , Esclerosis Múltiple/fisiopatología , Natalizumab/uso terapéutico , Corticoesteroides/uso terapéutico , Adulto , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Esclerosis Múltiple/patología , RecurrenciaRESUMEN
INTRODUCTION: Intervention for childhood obesity is a public health priority. The purpose of this study was to evaluate the effectiveness of an elementary school-based intervention against obesity in children. MATERIAL AND METHODS: Non-randomised controlled trial was conducted on children from first to fifth grade from two public schools of Avilés (Spain). The intervention lasted for 2 school years comprising healthy diet workshops, educational chats, educational meetings, informative written material, and promotion of physical activities. Primary outcome measure was body mass index z-score. Secondary outcomes included: obesity and overweight prevalence, waist circumference, dietary habits, and physical activity. RESULTS: A total of 382 (177 girls, 205 boys) out of 526 pupils of both schools were included in the study. Complete anthropometric data were obtained in 340 of the 382 individuals. Compared to children in control group, those in intervention group decreased body mass index z-score from 1.14 to 1.02 (P=.017), and improved KIDMED score from 7.33 to 7.71 points (P=.045). The percentage of students who carried on an optimal diet increased from 42.6% to 52.3% (P=.021). There were no statistical differences in the prevalence of obesity and overweight, or in waist circumference between the intervention and control groups. CONCLUSIONS: This school-based program resulted in modest beneficial changes in body mass index and diet quality.
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Ejercicio Físico , Conducta Alimentaria , Obesidad Infantil/prevención & control , Servicios de Salud Escolar , Índice de Masa Corporal , Niño , Preescolar , Femenino , Humanos , Masculino , PrevalenciaRESUMEN
No disponible
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Humanos , Masculino , Adulto , Glicol de Etileno/envenenamiento , Intoxicación/diagnóstico , Agente Extintor , Cetosis/prevención & control , Insuficiencia Renal/prevención & controlRESUMEN
La creciente capacidad de la medicina para producir más iatrogenia que nunca y el riesgo de insostenibilidad de los sistemas sanitarios han generado en los países desarrollados un nuevo concepto de prevención: la prevención cuaternaria, cuyo objetivo es contener la medicalización. La prevención cuaternaria es imprescindible en el fenómeno llamado disease mongering, que podría traducirse por mercantilización de las enfermedades. Potenciar este tipo de prevención y frenar las consecuencias del disease mongering requiere desarrollar todo el potencial institucional de la prevención y toda la voluntad personal de la contención; implica separarnos de la tutela innecesaria de la industria, ser críticos con nuestro trabajo, no ser maleficentes, respetar el principio de justicia sabiéndonos gestores de los limitados recursos públicos, y sentirnos responsables del coste social de oportunidad de las decisiones médicas En este trabajo analizamos desde este punto de vista los cribados en los recién nacidos, los avances en el área de la neonatología y la atención primaria de salud
The growing capacity of medicine to generate more iatrogenic events than ever, and the risk of unsustainability of health systems have led to new prevention concept: quaternary prevention aimed at restraining medicalization. Quaternary prevention is essential in the phenomenon called disease mongering, which could be translated as commercialization of disease. Encouraging this sort of prevention and halting the consequences of disease mongering requires the development of all the institutional potential for prevention, as well as all the personal willingness for restraint; it involves separating us from the unnecessary auspices of industry, being critical of our work, not being maleficent, respecting the principle of justice as managers of the limited public resources and making ourselves feel responsible for the social cost resulting from medical decisions. From this point of view, this work analyses neonatal screening, developments in the area of neonatology and primary health care
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Humanos , Medicalización/ética , Comercialización de los Servicios de Salud/ética , Bioética/tendencias , Mercantilización , Tamizaje Neonatal/ética , Atención Primaria de Salud/éticaRESUMEN
INTRODUCCIÓN: La prevalencia de anquiloglosia ha sido estimada alrededor del 4% de los recién nacidos vivos. Se desconoce la situación a nivel nacional. MATERIAL Y MÉTODOS: Estudio multicéntrico, observacional, prospectivo en el que participaron 6 hospitales asturianos. Durante 3 meses se exploró a todos los recién nacidos los días domingo, martes y jueves. Para el diagnóstico de anquiloglosia se utilizaron los criterios de Coryllos y Hazelbaker. RESULTADOS: Se exploró a 667 recién nacidos. La prevalencia de anquiloglosia fue del 12,11% (IC 95%: 9,58-14,64). El 62% eran varones. Uno de cada 4 niños con anquiloglosia tenía antecedentes familiares de frenillo lingual corto. Según la clasificación de Coryllos el tipo II fue el más frecuente (54%). CONCLUSIONES: La prevalencia de anquiloglosia en Asturias fue 2 o 3 veces superior a la esperada. Es necesario unificar los criterios diagnósticos, así como realizar estudios para conocer su asociación con dificultades en la lactancia u otros problemas posteriores
INTRODUCTION: The prevalence of ankyloglossia has been estimated at around 4% of live births. Its prevalence at national level is unknown. MATERIAL AND METHODS: Multicenter, prospective observational study. Six hospitals in Asturias took part. All newborns were examined on Sundays, Tuesdays and Thursdays for 3 months. Coryllos and Hazelbaker criteria were used to diagnose ankyloglossia. RESULTS: The prevalence in the 667 newborns examined was 12.11% (95% CI: 9.58 to 14.64), of whom 62% were male. One in 4 children with ankyloglossia had a family history. According to Coryllos' classification, type II was the most common (54%). CONCLUSIONS: The prevalence of ankyloglossia in Asturias was 2 to t3 times higher than expected. The diagnostic criteria for ankyloglossia needs to be unified, and further studies are required to determine the association with breastfeeding difficulties and other health problems
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Humanos , Masculino , Femenino , Recién Nacido , Frenillo Labial/anomalías , Frenillo Lingual/anomalías , Lactancia Materna/estadística & datos numéricos , Estudios Prospectivos , Tamizaje NeonatalRESUMEN
BACKGROUND AND AIM: Over the last 50 years, people in Spain have increasingly been eating their main meal away from home and are shifting from the typical Mediterranean diet (MD). In addition, wine consumption has decreased whereas beer intake has risen. Consequently, it is uncertain if the Mediterranean drinking pattern (MDP; moderate alcohol intake mainly from wine and during meals) is a habitual feature of the MD today. METHODS AND RESULTS: Cross-sectional study conducted from 2008 to 2010 among 8894 individuals representative of the Spanish population aged 18-64 years. Consumption of alcoholic beverages and food was collected with a validated diet history. Accordance with the MD was defined as a score ≥8 on the Mediterranean Diet Adherence Screener (MEDAS) or ≥5 in the Trichopoulou index (after excluding alcohol intake from both indices). Among individuals with MEDAS-based MD accordance, only 17.1% had a MDP. After adjustment for potential confounders, this drinking pattern showed a weak association with higher MD accordance (odds ratio (OR) 1.32; 95% confidence interval (CI) 1.12-1.57). Only 14.7% of those with Trichopoulou-based MD accordance had a MDP; this pattern showed an even weaker association with higher MD accordance (OR 1.17; 95% CI 1.01-1.36). Similar results were obtained when this drinking pattern was redefined to include persons who drank wine with or outside of meals, as well as those who were primarily beer drinkers. CONCLUSIONS: The MDP is not a habitual feature of the MD in the early XXI century in Spain.
Asunto(s)
Consumo de Bebidas Alcohólicas/tendencias , Dieta Mediterránea , Conducta Alimentaria , Adolescente , Adulto , Cerveza , Índice de Masa Corporal , Estudios Transversales , Ingestión de Energía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Actividad Motora , Cooperación del Paciente , Factores Socioeconómicos , España , Vino , Adulto JovenRESUMEN
The growing capacity of medicine to generate more iatrogenic events than ever, and the risk of unsustainability of health systems have led to new prevention concept: quaternary prevention aimed at restraining medicalization. Quaternary prevention is essential in the phenomenon called disease mongering, which could be translated as commercialization of disease. Encouraging this sort of prevention and halting the consequences of disease mongering requires the development of all the institutional potential for prevention, as well as all the personal willingness for restraint; it involves separating us from the unnecessary auspices of industry, being critical of our work, not being maleficent, respecting the principle of justice as managers of the limited public resources and making ourselves feel responsible for the social cost resulting from medical decisions. From this point of view, this work analyses neonatal screening, developments in the area of neonatology and primary health care.