Radiological assessment of response and adverse events associated with novel systemic oncological therapies.

The last decade has seen a paradigm shift in medical oncology treatment with the rise of novel systemic agents, principally molecular targeted therapy and immunotherapy. These new groups of anti-cancer treatment have revolutionised the prognostic landscape for certain patient cohorts with advanced disease, and it is hoped that through ongoing extensive clinical research, significant survival benefits may be demonstrated in the majority of tumour types. However, radiological response assessment of these new agents has become more nuanced for radiologists, as the behaviour of both responding and progressing tumour burden can be more diverse than with conventional chemotherapy. Additionally, radiologists need to be aware of adverse events associated with these treatments as some side effects carry a high morbidity/mortality and may manifest radiologically before they become clinically apparent. This review discusses radiological response assessment and adverse events associated with these novel agents, which have become fundamental aspects of systemic oncological therapy.

High throughput spectrometer for fast localized Doppler measurements.

A new custom-built duo spectrometer has been commissioned for fast localized Doppler measurements of plasma ions in the Madison Symmetric Torus. The instrument combines very high optical throughput (transmission efficiency of 6% and etendue of 0.80 mm(2) sr divided into two simultaneous measurements) with good resolution (lambda/Deltalambda=5600). The design is a double grating variant of the Czerny-Turner layout and has been carefully optimized for fast (100 kHz) measurements of the C VI line at 343.4 nm. The instrument is currently being applied for high speed charge exchange recombination spectroscopy measurements.

Spatially resolved measurements of ion heating during impulsive reconnection in the Madison Symmetric Torus.

The impurity ion temperature evolution has been measured during three types of impulsive reconnection events in the Madison Symmetric Torus reversed field pinch. During an edge reconnection event, the drop in stored magnetic energy is small and ion heating is observed to be limited to the outer half of the plasma. Conversely, during a global reconnection event the drop in stored magnetic energy is large, and significant heating is observed at all radii. For both kinds of events, the drop in magnetic energy is sufficient to explain the increase in ion thermal energy. However, not all types of reconnection lead to ion heating. During a core reconnection event, both the stored magnetic energy and impurity ion temperature remain constant. The results suggest that a drop in magnetic energy is required for ions to be heated during reconnection, and that when this occurs heating is localized near the reconnection layer.