[Incidence of anaplastic tumor in structure of other histologic forms of the thyroid gland cancer].

The degrees of invasiveness, proliferative activity, morphofunctional activity of nuclei in the thyroidal gland tumors were studied, while analyzing material, obtained in 1343 patients, suffering thyroidal gland cancer (THGC) and operated on in 2000-2013 yrs. Morphological point quantity of malignancy (as a criterion of the tumor progression grade) and mitotic activity in cellular population were determined in various kinds of THGC. Undifferentiated (anaplastic carcinoma) type of THGC is the most malignant one. There were determined a spindle-like, giant-cell and squamous-cell forms of undifferentiated THGC. The presence of sites of differentiated cancer in 33% of histological preparations witnesses the interrelationship with the earlier existed pathological process.

[Morphologic features of immune interrelationships in the feto-placental system in development of a large fetus and in retardation of intrauterine fetal development]. / Morfologicheskie osobennosti immunnykh vzaimootnoshenii v sisteme platsenta-plod pri krupnoplodii i zaderzhke vnutriutrobnogo razvitiia ploda.

Indirect criteria of the value of the immune placenta barrier in case of a large foetus are distinguished: relatively small volume of the fibrinoid substance, moderate synthesis by the syncytial epithelium of glucosaminoproteoglycans (GAPG), slight lymphoplasma cell infiltrates with a marked suppressor influence, the lack of antigens HLA = Dr on the trophoblast and formation of the adequate interrelation ship between the immune dependent placental structure and the thymus of the large foetus this allowing to retain the foetus up to 38-40 weeks or even more. In case of delay in the intrauterine foetus development there is a sharp increase of the fibrinoid substance, focal enhancement of GAPG production by the syncytial cells, decrease of the suppressor activity and the appearance in some cases in the trophoblast of antigens to HLA=Dr this being probably the manifestation of a premature exhaustion of compensatory-adaptive reactions in the placenta.