1.
Dokl Biol Sci
; 423: 464-8, 2008.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19213438
2.
FEBS Lett
; 462(3): 407-10, 1999 Dec 03.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10622735
RESUMEN
For the first time small nuclear ribonucleoprotein particles (alpha-RNP) tightly bound to chromatin as well as cytoplasmic alpha-RNP are shown to possess strong and regulated endonuclease activity specific for mRNAs and hnRNAs. The enzymatic nature of this activity is confirmed, and the optimal conditions detected. This RNase activity is controlled by the action of a differentiating stimulus, dimethylsulfoxide, in human K562 cells. Small alpha-RNP involvement in the coordinated control of stability of pre-messenger RNA and messenger RNA molecules is suggested.
Asunto(s)
Endorribonucleasas/metabolismo , Ribonucleoproteínas Citoplasmáticas Pequeñas/metabolismo , Ribonucleoproteínas Nucleares Pequeñas/metabolismo , Elementos Alu , Animales , Northern Blotting , Humanos , Células K562 , Hígado/metabolismo , Masculino , Hibridación de Ácido Nucleico , ARN Nuclear Heterogéneo/metabolismo , ARN Mensajero/metabolismo , Ratas , Ratas Wistar , Ribonucleoproteínas Citoplasmáticas Pequeñas/genética , Ribonucleoproteínas Nucleares Pequeñas/genética
3.
Monogr Dev Biol
; 23: 196-208, 1992.
Artículo
en Inglés
| MEDLINE
| ID: mdl-1614435