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1.
Rev. bras. ginecol. obstet ; Rev. bras. ginecol. obstet;43(2): 126-130, Feb. 2021. tab
Artículo en Inglés | LILACS | ID: biblio-1156095

RESUMEN

Abstract Objective The present study aimed to assess the effect of Melissa Officinalis L. (a combination of lemon balm with fennel fruit extract) compared with citalopram and placebo on the quality of life of postmenopausal women with sleep disturbance. Methods The present study is a randomized, double-blind, placebo clinical trial among 60 postmenopausal women with sleep disturbance who were referred to a university hospital from 2017 to 2019. The participants were randomized to receive M. Officinalis L. (500 mg daily), citalopram (30 mg) or placebo once daily for 8 weeks. The Menopause-Specific Quality of Life (MENQOL) questionnaire was self-completed by each participant at baseline and after 8 weeks of the intervention and was compared between groups. Results The mean for all MENQOL domain scores were significantly improved in the M. Officinalis L. group compared with citalopram and placebo (p < 0.001). The mean ± standard deviation (SD) after 8 weeks in the M. Officinalis L., citalopram and placebo groups was 2.2 ± 0.84 versus 0.56 ± 0.58 versus 0.36 ± 0.55 in the vasomotor (p < 0.001), 1.02 ± 0.6 versus 0.28 ± 0.2 versus 0.17 ± 0.1 in the psychomotor-social (p < 0.001), 0.76 ± 0.4 versus 0.25 ± 0.1 versus 0.11 ± 0.1 in the physical and 2.3 ± 1.0 versus 0.35 ± 0.5 versus 0.41 ± 0.5 in the sexual domain, respectively. Conclusions The results revealed that M. Officinalis L. may be recommended for improving the quality of life of menopausal women with sleep disturbance. Trial registration The present study was registered by the name "Comparison of the efficacy of citalopram and compound of Asperugo procumbens and foeniculum vulgare in treatment of menopausal disorders" with the code IRCT2013072714174N1 in the Iranian Registry of Clinical Trials (IRCT).


Asunto(s)
Trastornos del Sueño-Vigilia/tratamiento farmacológico , Extractos Vegetales/uso terapéutico , Citalopram/uso terapéutico , Inhibidores Selectivos de la Recaptación de Serotonina/uso terapéutico , Melissa , Calidad de Vida , Trastornos del Sueño-Vigilia/psicología , Extractos Vegetales/administración & dosificación , Citalopram/administración & dosificación , Método Doble Ciego , Encuestas y Cuestionarios , Resultado del Tratamiento , Inhibidores Selectivos de la Recaptación de Serotonina/administración & dosificación , Posmenopausia , Irán , Fitoterapia , Persona de Mediana Edad
2.
Rev Bras Ginecol Obstet ; 43(2): 126-130, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33465795

RESUMEN

OBJECTIVE: The present study aimed to assess the effect of Melissa Officinalis L. (a combination of lemon balm with fennel fruit extract) compared with citalopram and placebo on the quality of life of postmenopausal women with sleep disturbance. METHODS: The present study is a randomized, double-blind, placebo clinical trial among 60 postmenopausal women with sleep disturbance who were referred to a university hospital from 2017 to 2019. The participants were randomized to receive M. Officinalis L. (500 mg daily), citalopram (30 mg) or placebo once daily for 8 weeks. The Menopause-Specific Quality of Life (MENQOL) questionnaire was self-completed by each participant at baseline and after 8 weeks of the intervention and was compared between groups. RESULTS: The mean for all MENQOL domain scores were significantly improved in the M. Officinalis L. group compared with citalopram and placebo (p < 0.001). The mean ± standard deviation (SD) after 8 weeks in the M. Officinalis L., citalopram and placebo groups was 2.2 ± 0.84 versus 0.56 ± 0.58 versus 0.36 ± 0.55 in the vasomotor (p < 0.001), 1.02 ± 0.6 versus 0.28 ± 0.2 versus 0.17 ± 0.1 in the psychomotor-social (p < 0.001), 0.76 ± 0.4 versus 0.25 ± 0.1 versus 0.11 ± 0.1 in the physical and 2.3 ± 1.0 versus 0.35 ± 0.5 versus 0.41 ± 0.5 in the sexual domain, respectively. CONCLUSIONS: The results revealed that M. Officinalis L. may be recommended for improving the quality of life of menopausal women with sleep disturbance. TRIAL REGISTRATION: The present study was registered by the name "Comparison of the efficacy of citalopram and compound of Asperugo procumbens and foeniculum vulgare in treatment of menopausal disorders" with the code IRCT2013072714174N1 in the Iranian Registry of Clinical Trials (IRCT).


Asunto(s)
Citalopram/uso terapéutico , Melissa , Extractos Vegetales/uso terapéutico , Inhibidores Selectivos de la Recaptación de Serotonina/uso terapéutico , Trastornos del Sueño-Vigilia/tratamiento farmacológico , Citalopram/administración & dosificación , Método Doble Ciego , Femenino , Humanos , Irán , Persona de Mediana Edad , Fitoterapia , Extractos Vegetales/administración & dosificación , Posmenopausia , Calidad de Vida , Inhibidores Selectivos de la Recaptación de Serotonina/administración & dosificación , Trastornos del Sueño-Vigilia/psicología , Encuestas y Cuestionarios , Resultado del Tratamiento
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