Asunto(s)
Ensayos Clínicos como Asunto/normas , Malformaciones Arteriovenosas Intracraneales/clasificación , Malformaciones Arteriovenosas Intracraneales/diagnóstico , Terminología como Asunto , Determinación de la Presión Sanguínea/métodos , Encéfalo/irrigación sanguínea , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Cateterismo , Angiografía Cerebral , Arterias Cerebrales/patología , Hemorragia Cerebral/etiología , Hemorragia Cerebral/prevención & control , Venas Cerebrales/patología , Embolización Terapéutica , Cefalea/etiología , Humanos , Malformaciones Arteriovenosas Intracraneales/patología , Malformaciones Arteriovenosas Intracraneales/terapia , Selección de Paciente , Pronóstico , Proyectos de Investigación/normas , Factores de Riesgo , Índice de Severidad de la EnfermedadRESUMEN
OBJECTIVE: Radiosurgery has emerged as an alternative treatment modality for cranial base tumors in patients deemed not suited for primary surgical extirpation, patients with recurrent or residual tumor after open surgery, or patients who refuse surgical treatment. We review our short-term experience with radiosurgical management of cavernous sinus region tumors with the Leksell gamma knife. METHODS: From August 1994 to February 1999, 69 patients with cavernous sinus lesions were treated in 72 separate treatment sessions. The tumor type distribution was 29 pituitary adenomas, 35 meningiomas, 4 schwannomas, and 1 paraganglioma. The median follow-up was 122 weeks. Lesions were stratified according to a five-level surgical grade. The grade distribution of the tumors was as follows: Grade I, 13; Grade II, 21; Grade III, 19; Grade IV, 12; Grade V, 4. Median tumor volume was 4.7 cm3. The median radiation dose was 15 Gy to the 50% isodose line. Median maximal radiation dose was 30 Gy. RESULTS: Analysis of tumor characteristics and radiation dose to optic nerve and pontine structures revealed a significant correlation between distance and dose. Much lower correlation coefficients were found between tumor volume and dose. One lesion in this series had evidence of transient progression and later regression on follow-up radiographic studies. No other lesions in this series were demonstrated to have exhibited progression. Complications after radiosurgical treatment were uncommon. Two patients had cranial nerve deficits after treatment. One patient with a surgical Grade III pituitary adenoma had VIth cranial nerve palsy 25 months after radiosurgical treatment that spontaneously resolved 10 months later. A patient with a bilateral pituitary adenoma experienced bilateral VIth cranial nerve palsy 3 months after treatment that had not resolved at 35 months after treatment. Six patients with preoperative cranial nerve deficits experienced resolution or improvement of their deficits after treatment. One patient with a prolactin-secreting adenoma experienced normalization of endocrine function with return of menses. CONCLUSION: Radiosurgical treatment represents an important advance in the management of cavernous sinus tumors, with low risk of neurological deficit in comparison with open surgical treatment, even in patients with high surgical grades.
Asunto(s)
Seno Cavernoso/cirugía , Radiocirugia , Neoplasias Vasculares/cirugía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Enfermedades de los Nervios Craneales/etiología , Enfermedades de los Nervios Craneales/fisiopatología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias , Pronóstico , Radiometría , Radiocirugia/efectos adversos , Recuperación de la Función , Estudios Retrospectivos , Resultado del Tratamiento , Neoplasias Vasculares/complicacionesRESUMEN
OBJECTIVE: A major impetus of the "brain attack" campaign is the early recognition and treatment of acute stroke. Critical to this goal is the education of physicians during their residency training. METHODS: Resident physicians in Los Angeles who were in family practice (18%), internal medicine (51%), emergency medicine (20%), and neurology (11%) and had already completed their first year of training responded to a questionnaire on stroke and the treatment of carotid stenosis. RESULTS: Of the 266 respondents, 76% had heard of the "brain attack" campaign, 22% did not identify dysarthria as a symptom of stroke, and 21% did not identify obtundation as a presentation of stroke. Twenty-eight percent chose not to use tissue plasminogen activator for acute ischemic stroke, and 60% recognized the need to begin treatment within 3 hours. More than 90% of respondents were able to identify correct screening tests for patients with suspected carotid stenosis. However, 56% responded that they would not advocate operating on patients with asymptomatic severe stenosis (>70%) until stenosis reached a critical value (85%). Conversely, 45% would recommend operative treatment for symptomatic patients who had less than 60% stenosis. Sixty-eight percent would refer patients to vascular surgeons, 14% to neurosurgeons, and 17% to both for carotid endarterectomy. CONCLUSION: Recognition of stroke as a medical emergency is improving. However, significant progress can still be made in the recognition of stroke symptoms. Primary care and neurology residents remain skeptical about carotid endarterectomy for asymptomatic patients, whereas there is enthusiasm for treating stroke survivors. Education by members of the surgical community could promote the aggressive treatment of asymptomatic patients to prevent stroke.
Asunto(s)
Actitud del Personal de Salud , Arterias Carótidas/cirugía , Servicios Médicos de Urgencia , Endarterectomía , Internado y Residencia , Accidente Cerebrovascular/terapia , Estenosis Carotídea/diagnóstico , Estenosis Carotídea/terapia , Recolección de Datos , Fibrinolíticos/uso terapéutico , Humanos , Derivación y Consulta , Accidente Cerebrovascular/complicaciones , Accidente Cerebrovascular/diagnóstico , Activador de Tejido Plasminógeno/uso terapéuticoRESUMEN
OBJECTIVE: In recent years, stereotactic radiosurgery has been growing in popularity as a treatment modality for metastatic disease to the brain. The technique has advantages of reduced cost and low morbidity compared with open surgical treatment. Furthermore, it avoids the potential cognitive side effects of fractionated whole-brain radiotherapy. We undertook this study to determine the usefulness of adjuvant radiation therapy and to determine prognostic factors in patients treated with stereotactic radiosurgery. METHODS: We reviewed our series of patients with metastatic tumors treated using gamma knife stereotactic radiosurgery from August 1994 to February 1999. Nonparametric methods were used to compare treatment subgroups by demographic features including age, Karnofsky Performance Scale score, diagnosis, and systemic disease status. Univariate and multivariate analyses of survival and freedom from progression were performed using Kaplan-Meier and Cox proportional hazards regression techniques. RESULTS: This study included 190 patients harboring 431 lesions who were treated in 263 treatment sessions. The median follow-up after radiosurgery was 36 weeks for all patients. The median actuarial survival from the time of radiosurgery in all patients was 34 weeks. When patients were stratified according to tumor histology, those without melanoma had a median survival of 39 weeks, and those with melanoma had a median survival of 28 weeks. The cause of death could be determined in 122 (92%) of the patients known to have died during the data capture period. For patients harboring melanoma, death was attributable to systemic disease in 31 (47%), to central nervous system-related processes in 29 (44%), and to unknown causes in 6 (9%). For non-melanoma patients, death was attributable to systemic disease in 45 (68%), to central nervous system-related processes in 17 (26%), and to unknown causes in 4 (6%). Significantly improved survival (P = 0.002) was observed in patients with controlled systemic disease. No significant difference in survival could be ascertained for patients presenting with up to four lesions, although patients with a total tumor volume greater than 9 cc had shortened survival. No survival benefit could be demonstrated for whole-brain radiotherapy administered either concomitantly or after radiosurgery. CONCLUSION: Factors correlated with significantly improved survival included controlled systemic disease and non-melanoma histology. We found no significant survival benefit that could be discerned from adjuvant whole-brain radiotherapy in this patient group.
Asunto(s)
Neoplasias Encefálicas/secundario , Neoplasias Encefálicas/cirugía , Radiocirugia , Técnicas Estereotáxicas , Adulto , Anciano , Anciano de 80 o más Años , Neoplasias Encefálicas/mortalidad , Causas de Muerte , Progresión de la Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Recurrencia Local de Neoplasia/cirugía , Pronóstico , Radiocirugia/efectos adversos , Retratamiento , Estudios Retrospectivos , Análisis de SupervivenciaRESUMEN
OBJECTIVE: Radiosurgery has emerged as an important modality in the management of metastatic disease to the brain. A number of groups have published results suggesting that high local control rates can be achieved, with improvements in overall survival that rival the results of open surgical treatment. Typically, however, whole-brain radiotherapy has been used in the salvage therapy of patients who have undergone previous craniotomy or radiosurgery. We describe our experience with radiosurgical salvage in this group of patients. METHODS: From August 1994 to February 1999, 190 patients with brain metastasis were treated with gamma unit radiosurgery at our institution. A subset of 45 patients, who underwent radiosurgical salvage for new tumors in a region remote from an initially treated tumor, form the population base for this study. The usual criteria for repeat treatment were recurrence with five or fewer discrete lesions outside of the previously treated radiosurgical volume and Karnofsky Performance Scale score of at least 70. Survival and freedom from progression were measured from the time of radiosurgical treatment and were computed by the Kaplan-Meier product-limit method. Two or more curves were compared using the log-rank method. RESULTS: In this subgroup of patients, a total of 176 tumors were treated. The median time from first radiosurgical procedure to first salvage was 17.4 weeks. Median survival from the second radiosurgical intervention was 28 weeks. Of the 45 study patients, 34 patients underwent a single salvage procedure, 10 patients underwent two salvage procedures, and 1 patient had three salvage procedures. The actuarial freedom from progression for treated tumors at 52 weeks was 92.4%. Patients undergoing upfront whole-brain irradiation were less likely to require salvage therapy (P = 0.008). There were 33 deaths after salvage radiosurgery during the reporting period. Central nervous system causes accounted for 13 deaths, whereas 19 deaths resulted from systemic disease. The cause of death in one patient could not be determined. No statistically significant advantage in overall survival could be demonstrated in patients treated with whole-brain irradiation. CONCLUSION: Radiosurgical salvage represents a valuable means of treatment for central nervous system recurrence for patients who have undergone previous treatment for metastatic disease to the brain. Whole-brain irradiation may reduce the need for salvage therapy, but no advantage in overall survival could be demonstrated in this subgroup.
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Neoplasias Encefálicas/secundario , Neoplasias Encefálicas/cirugía , Radiocirugia , Terapia Recuperativa , Neoplasias Encefálicas/fisiopatología , Progresión de la Enfermedad , Humanos , Estado de Ejecución de Karnofsky , Persona de Mediana Edad , Recurrencia Local de Neoplasia/cirugía , Complicaciones Posoperatorias , Reoperación , Análisis de SupervivenciaRESUMEN
OBJECTIVE: We describe a method of protecting the distal cerebral circulation during carotid angioplasty and report results using the technique in 17 procedures. METHODS: Eleven men and five women with carotid stenoses ranging in severity from 70 to 95% underwent the procedure. The technique was used bilaterally in one patient. A compliant silicone balloon was used to occlude the distal internal carotid artery during the angioplasty phase, when the largest number of emboli are generated. After angioplasty, debris was then flushed into the external circulation while the occlusion balloon remained inflated. The subsequent passage of an exchange guidewire through the angioplasty catheter, with the occlusion balloon deflated, allowed continuous guidewire access across the area of stenosis and facilitated the subsequent placement of a stent. RESULTS: The technique was successful in 16 (94%) of 17 procedures. In the one patient in whom the occlusion balloon could not be advanced across the stenosis, the patient experienced a transient ischemic attack after subsequent angioplasty that was performed without protection. Otherwise, no complications occurred among the 15 patients undergoing successful, balloon-protected angioplasty. Inflation times for the occlusion balloon did not exceed 5 minutes in any patient. CONCLUSION: This method of cerebral protection prevents the intracranial embolization of thrombus and atherosclerotic debris, while allowing continuous guidewire access across the site of stenosis. The success of this technique and a similar method used by Theron et al. supports the use of balloon protection as a means of reducing the risk of stroke associated with carotid angioplasty.
Asunto(s)
Angioplastia , Enfermedades de las Arterias Carótidas/terapia , Cateterismo , Accidente Cerebrovascular/prevención & control , Anciano , Anciano de 80 o más Años , Enfermedades de las Arterias Carótidas/diagnóstico por imagen , Arteria Carótida Interna , Angiografía Cerebral , Femenino , Humanos , Ataque Isquémico Transitorio/etiología , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias , Resultado del TratamientoRESUMEN
OBJECTIVE AND IMPORTANCE: Despite recent advances in technology, parent vessel coil herniation occasionally complicates successful Guglielmi detachable coil embolization, particularly in wide-necked aneurysms. We report endovascular stent deployment performed in two patients specifically to treat this complication. CLINICAL PRESENTATION: Two patients underwent Guglielmi detachable coil embolization of cavernous segment aneurysms. Both developed coil herniation into the internal carotid artery. In one patient, the herniation occurred during the initial procedure; in the other, it was discovered in a delayed fashion during a follow-up examination for ocular symptoms. INTERVENTION: In both patients, endovascular stent deployment was performed to isolate the herniated portion of the coil from the internal carotid lumen. Follow-up angiography at 6 months demonstrated no aneurysm recanalization and no stenosis of the parent internal carotid artery in the stented region in either patient. CONCLUSION: The use of intraluminal stents has been reported to be a helpful technical adjunct to the conventional endovascular treatment of aneurysms and balloon angioplasty. One additional indication for the use of this technology is sequestering herniated coils from the lumen of the parent artery to reduce potential embolic or occlusive sequelae.
Asunto(s)
Embolización Terapéutica/efectos adversos , Embolización Terapéutica/instrumentación , Aneurisma Intracraneal/terapia , Stents , Angiografía de Substracción Digital , Falla de Equipo , Femenino , Humanos , Aneurisma Intracraneal/diagnóstico , Imagen por Resonancia Magnética , Persona de Mediana Edad , RetratamientoRESUMEN
We reviewed our experience with intraoperative angiography in the management of 7 cerebral aneurysms and 15 arteriovenous malformations (AVMs) in children over the past 5 years. The patients ranged from 4 months to 18 years of age with a mean age of 9 years. In 4 of the 22 cases, angiography provided information that led to changes during surgery. In 3 cases, the intraoperative angiogram revealed residual AVMs that were then completely resected. In 1 patient with an anterior circulation aneurysm, intraoperative studies revealed findings which resulted in clip repositioning. Intraoperative angiography added a mean of 43 (+/-19) min to the operative time, with a mode of 40 minutes. There was 1 complication, a groin hematoma that readily resolved. Intraoperative angiography prolongs to operative course; however, it is a useful adjunct to the management of vascular disorders in children. We now routinely use and recommend intraoperative angiography to assist with the surgical management of vascular malformations in children.
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Angiografía Cerebral/métodos , Aneurisma Intracraneal/cirugía , Malformaciones Arteriovenosas Intracraneales/cirugía , Cuidados Intraoperatorios , Adolescente , Niño , Preescolar , Humanos , Lactante , Estudios RetrospectivosRESUMEN
We review 190 consecutive patients with 434 metastatic tumors treated by gamma knife stereotactic radiosurgery, from August 1994 to February 1999. Median actuarial survival for all patients was 34 weeks. Factors correlated with significantly improved survival included controlled systemic disease and nonmelanoma histology. We found that no significant survival benefit could be discerned from adjuvant whole brain radiotherapy in this patient group. Survival was not statistically different for patients initially presenting with 1-4 metastases at initial treatment.
Asunto(s)
Neoplasias Encefálicas/secundario , Neoplasias Encefálicas/cirugía , Radiocirugia , Técnicas Estereotáxicas , Progresión de la Enfermedad , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Recurrencia Local de Neoplasia/diagnóstico , Análisis de SupervivenciaRESUMEN
OBJECTIVE: A number of anteriorly located cranial base and extracranial lesions receive their vascular supply wholly or in part from the ophthalmic artery, and embolization of the ophthalmic artery can be helpful in the management of these lesions, either as the primary treatment or as an adjunct to surgery. We present situations in which the embolization of lesions involving the ophthalmic artery was performed to effect a partial or total cure of the lesion. METHODS: Twelve patients underwent a total of 15 embolization attempts on lesions involving the ophthalmic artery. Four patients had arteriovenous malformations of the orbit, four had dural arteriovenous fistulae, two had orbital meningiomas, one had a planum sphenoidale meningioma, and one had a juvenile nasal angiofibroma. In each case, a Tracker No. 18 microcatheter (Target Therapeutics, Inc., Fremont, CA) was navigated into the ophthalmic artery using a steerable guidewire and digital road mapping. Embolic agents included polyvinyl alcohol particles ranging from 350 to 1500 microm in diameter, 2-mm platinum microcoils, and n-butyl-cyanoacrylate. In 12 of 15 cases, lidocaine and amytal provocation tests were conducted before any attempt at embolization to assess the role of the ophthalmic artery in vision. RESULTS: Embolization was successfully performed in the 14 situations in which it was attempted. Positive results of two lidocaine/amytal tests were noted. In one case, embolization was not attempted. In the other case, a larger caliber embolic agent (2-mm platinum coils) was used. A single transient decrease in visual acuity lasting 4 days was the only embolization-related complication. CONCLUSION: Proper case selection, judicious use of embolic agents, and use of provocative testing can result in safe embolization of lesions supplied by the ophthalmic artery.
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Angiofibroma/terapia , Malformaciones Arteriovenosas/terapia , Duramadre/irrigación sanguínea , Embolización Terapéutica , Neoplasias Meníngeas/terapia , Meningioma/terapia , Neoplasias Nasales/terapia , Arteria Oftálmica , Neoplasias Orbitales/terapia , Adolescente , Adulto , Anciano , Amobarbital , Angiofibroma/irrigación sanguínea , Angiofibroma/cirugía , Fístula Arteriovenosa/cirugía , Fístula Arteriovenosa/terapia , Malformaciones Arteriovenosas/cirugía , Terapia Combinada , Embolización Terapéutica/efectos adversos , Embolización Terapéutica/instrumentación , Embolización Terapéutica/métodos , Enbucrilato/uso terapéutico , Femenino , Humanos , Lactante , Lidocaína , Masculino , Neoplasias Meníngeas/irrigación sanguínea , Neoplasias Meníngeas/cirugía , Meningioma/irrigación sanguínea , Meningioma/cirugía , Persona de Mediana Edad , Neoplasias Nasales/irrigación sanguínea , Neoplasias Nasales/cirugía , Arteria Oftálmica/anatomía & histología , Neoplasias Orbitales/irrigación sanguínea , Neoplasias Orbitales/cirugía , Tamaño de la Partícula , Alcohol Polivinílico/uso terapéutico , Prótesis e Implantes , Arteria Retiniana/anatomía & histología , Resultado del Tratamiento , Trastornos de la Visión/etiología , Trastornos de la Visión/prevención & controlRESUMEN
OBJECTIVE AND IMPORTANCE: Vertebrobasilar insufficiency resulting from disease of the subclavian artery is well recognized. Usually, this occurs as the "subclavian steal" syndrome in the context of chronic subclavian stenosis and is consequently well tolerated because of collateralization. Acute disruption of the hemodynamics of the aortic arch vessels, however, can produce disastrous sequelae. CLINICAL PRESENTATION: We present three cases of iatrogenic vertebrobasilar insufficiency sustained as complications of surgery of the left subclavian artery or its distal continuation. The cases were chosen from a review of approximately 400 emergency neurosurgery consultations requested at the Los Angeles County Hospital between November 1995 and February 1996. INTERVENTION: The first patient underwent repair of a traumatic brachial artery occlusion and awoke postoperatively with bilateral cortical blindness, right hemiparesis, and multiple cranial nerve deficits that were most likely caused by acute subclavian steal. The second underwent removal of a subclavian embolus and developed bilateral cerebellar infarction leading to persistent coma, possibly from inadvertent embolization of the vertebral artery during surgery. The third underwent resection and bypass grafting of a subclavian aneurysm. Good backflow was reported when the vertebral artery was disarticulated from the subclavian artery, and this vessel was not reimplanted into the graft. The patient suffered massive cerebellar infarction leading rapidly to brain death. CONCLUSION: There are myriad ways in which the inherent redundancy of the vertebrobasilar system may be jeopardized, and when this protective mechanism fails, the results can be disastrous. Flow through the vertebral arteries may be compromised by thrombosis, embolization, dissection, inappropriate ligation, excessive head rotation, hypotension, vasospasm, or acute subclavian steal. These examples illustrate the importance of understanding the complex physiology of posterior fossa circulation as the basis of pre-, intra-, and postoperative management of patients undergoing surgery of the subclavian artery.
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Aneurisma/cirugía , Implantación de Prótesis Vascular , Arteria Braquial/cirugía , Daño Encefálico Crónico/etiología , Infarto Cerebral/etiología , Embolectomía/efectos adversos , Embolia/cirugía , Enfermedad Iatrogénica , Complicaciones Intraoperatorias/etiología , Estado Vegetativo Persistente/etiología , Complicaciones Posoperatorias/etiología , Arteria Subclavia/cirugía , Síndrome del Robo de la Subclavia/etiología , Insuficiencia Vertebrobasilar/etiología , Enfermedad Aguda , Adulto , Anciano , Arteria Axilar/cirugía , Arteria Braquial/lesiones , Arteria Braquial/fisiopatología , Daño Encefálico Crónico/fisiopatología , Isquemia Encefálica/etiología , Isquemia Encefálica/fisiopatología , Enfermedades Cardiovasculares/complicaciones , Cateterismo/efectos adversos , Catéteres de Permanencia/efectos adversos , Infarto Cerebral/fisiopatología , Circulación Cerebrovascular , Resultado Fatal , Femenino , Humanos , Enfermedad Iatrogénica/prevención & control , Complicaciones Intraoperatorias/fisiopatología , Ligadura/efectos adversos , Persona de Mediana Edad , Monitoreo Intraoperatorio , Estado Vegetativo Persistente/fisiopatología , Complicaciones Posoperatorias/fisiopatología , Postura , Estudios Retrospectivos , Síndrome del Robo de la Subclavia/fisiopatología , Arteria Vertebral/lesiones , Arteria Vertebral/cirugía , Insuficiencia Vertebrobasilar/fisiopatología , Insuficiencia Vertebrobasilar/prevención & controlRESUMEN
The authors present a patient with a large acoustic neuroma that exhibited an unusual vascular architecture. Magnetic resonance imaging demonstrated multiple flow voids in and around the mass. At surgery, intra- and extratumoral vascularity was arterialized due to luxurious shunting. Two attempts at removal produced severe engorgement and pulsatility of the surrounding brain, dramatically narrowing the operative exposure. Piecemeal resection of the tumor seemed to redistribute blood flow resulting in engorgement of the surrounding brain, analogous to perfusion breakthrough following AVM resection. Treatment strategies similar to those used for AVM resection may be indicated when encountering a hypervascular tumor.
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Cerebelo/irrigación sanguínea , Neoplasias de los Nervios Craneales/irrigación sanguínea , Neovascularización Patológica , Neuroma Acústico/irrigación sanguínea , Adulto , Malformaciones Arteriovenosas/cirugía , Presión Sanguínea , Angiografía Cerebral , Arterias Cerebrales , Venas Cerebrales , Neoplasias de los Nervios Craneales/diagnóstico , Neoplasias de los Nervios Craneales/cirugía , Nervio Facial/irrigación sanguínea , Nervio Facial/cirugía , Humanos , Imagen por Resonancia Magnética , Masculino , Neuroma Acústico/diagnóstico , Neuroma Acústico/cirugíaRESUMEN
BACKGROUND: To examine our initial experience in carotid stenting (CS) for the prevention of stroke in patients with high-grade carotid stenoses. METHODS: The authors performed 26 CS procedures in 25 carotid vessels in 22 patients over a 15-month period. All carotid stenoses treated, except one, were 70% or greater. Of all CS procedures, 84% were performed for obstructing atherosclerotic plaques. CS was performed in one patient each for carotid dissection and pseudoaneurysms caused by a gunshot wound, post-radiation stenosis, post-carotid endarterectomy (CEA) restenosis, and a flow-obstructing post-CEA intimal flap. Of all patients, 68.2% were symptomatic, with a history of stroke or transient ischemic attacks ipsilateral to the treated carotid artery. In addition, 36.4% of our patients were either hospitalized or required skilled nursing care before CS because of severe neurologic deficits. Using the Sundt CEA-risk classification system, 59.1% of our patients were classified as Grade III and 40.9% were Grade IV pre-CS. All but one patient had either a compelling medical or anatomic reason for endovascular treatment of their carotid disease. We used both Wallstents and Palmaz stents, and all procedures were performed via the transfemoral route. Three procedures were performed in conjunction with detachable platinum coil embolization for multiple carotid pseudoaneurysms, a residual carotid "stump" after previous ICA thrombosis, and an ipsilateral MCA saccular aneurysm. RESULTS: We had a 96.2% procedural technical success rate. There was one death in our series 3 weeks post-CS attributable to myocardial infarction. Despite a high 30-day combined death, stroke, and ipsilateral blindness rate of 27.3% (6/22 patients), only two ipsilateral strokes directly related to CS occurred (7.7% per procedures performed) from which one patient recovered fully within 5 days. The average follow-up post-CS was 5.9 months (range, 3 weeks-15 months). Of successfully treated vessels, 58.3% have undergone 6-month follow-up vascular imaging, which has revealed a 14.3% rate of occlusion or restenosis greater than 50%. At or beyond 1 month post-CS, 19 of 21 surviving patients (90.5%) were ambulatory, fluent of speech, and independent, and none has thus far suffered a delayed stroke or TIA. CONCLUSION: CS seems to be a reasonable alternative to medical management for the treatment of carotid disease in patients deemed to be poor candidates for standard carotid surgery. Longer term follow-up is necessary to assess the durability of carotid revascularization using CS.
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Arteriopatías Oclusivas/cirugía , Arterias Carótidas/cirugía , Trastornos Cerebrovasculares/cirugía , Stents , Adulto , Anciano , Anciano de 80 o más Años , Arteriopatías Oclusivas/diagnóstico , Angiografía Cerebral/métodos , Trastornos Cerebrovasculares/diagnóstico , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Medición de RiesgoAsunto(s)
Aneurisma Intracraneal/cirugía , Neurocirugia/tendencias , Procedimientos Neuroquirúrgicos/métodos , Procedimientos Quirúrgicos Vasculares/métodos , Humanos , Liderazgo , Microcirugia/métodos , Neurocirugia/educación , Neurocirugia/organización & administración , Procedimientos Neuroquirúrgicos/tendencias , Rol del Médico , Sociedades Médicas , Estados Unidos , Procedimientos Quirúrgicos Vasculares/tendenciasRESUMEN
OBJECTIVE AND IMPORTANCE: We describe an unusual case of an 8-year-old male patient presenting with a traumatic basilar artery aneurysm associated with a basilar-cavernous fistula. CLINICAL PRESENTATION: The fistula occurred as the result of an accident involving a vehicle and a pedestrian. The patient originally presented in a coma and with a dense left hemiparesis. INTERVENTION: The traumatic basilar aneurysm and basilar-cavernous fistula were successfully occluded by endovascular coil embolization in two sessions. By 6 months after injury, the patient had made an excellent neurological recovery, requiring only a left leg brace for walking. CONCLUSION: Endovascular coil embolization provided an effective treatment option in the case of this complex and unusual arteriovenous fistula. We discuss the radiological and clinical features of related traumatic neurovascular lesions.
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Fístula Arteriovenosa/etiología , Fístula Arteriovenosa/terapia , Arteria Basilar/lesiones , Seno Cavernoso/lesiones , Traumatismos Craneocerebrales/complicaciones , Embolización Terapéutica/métodos , Heridas Penetrantes/complicaciones , Angiografía Cerebral , Niño , Embolización Terapéutica/instrumentación , Humanos , Masculino , Tomografía Computarizada por Rayos XRESUMEN
Endarterectomy is the treatment of choice for patients with symptomatic stenosis of the internal carotid artery. Recently, debate has arisen over the potential benefits of endovascular techniques. Although retrospective analyses of angioplasty and stenting procedures suggest comparable clinical efficacy to endarterectomy, prospective evaluation is pending. The authors review the status of the debate and discuss those issues on both sides that are particularly contentious and clinically relevant.
RESUMEN
A 53-year-old woman spontaneously incurred a right trigeminal artery-cavernous sinus fistula, manifested by an intracranial bruit and right sixth nerve palsy. This lesion was successfully managed by coil embolization via the transvenous and transarterial routes.
Asunto(s)
Fístula Arteriovenosa/terapia , Arteria Carótida Interna/anomalías , Seno Cavernoso , Embolización Terapéutica , Fístula Arteriovenosa/diagnóstico por imagen , Arteria Basilar/anomalías , Arteria Basilar/diagnóstico por imagen , Arteria Carótida Interna/diagnóstico por imagen , Seno Cavernoso/diagnóstico por imagen , Angiografía Cerebral , Femenino , Humanos , Persona de Mediana EdadRESUMEN
The risk of focal infarction secondary to the induced reversible arrest of local arterial flow during microsurgical dissection of middle cerebral artery (MCA) aneurysms was evaluated further to define the optimal approach to temporary arterial occlusion. To compare the effectiveness of potential brain-protection anesthetics, a group of patients treated with the intravenous agents propofol, etomidate, and pentobarbital, administered individually or in combination, was compared to a group treated with the inhalational agent isoflurane. Forty-nine consecutive MCA aneurysm surgeries involving the temporary clipping of the parent vessel were retrospectively reviewed. Thirty-eight patients received intravenous brain-protection (IVBP) anesthesia. Groups of patients with and without infarctions, and receiving and not receiving IVBP anesthesia, were compared based on the duration and nature of temporary arterial occlusion. Postoperative radiographic evidence of new infarction was used as the threshold for failure of occlusion tolerance. The overall infarction rate was 22.4% (11 of 49 patients), including 15.8% (six of 38 patients) in the IVBP group versus 45.5% (five of 11 patients) in the group that did not receive brain protection (NBP). In the NBP group, the mean duration of temporary occlusion was 3.9 +/- 2.2 minutes for patients without infarction versus 12.2 +/- 4.3 minutes for patients with focal infarction (p < 0.01). In contrast, the mean duration was 13.6 +/- 10.6 minutes for patients without infarction and 18.5 +/- 9.9 minutes for patients with infarction in the IVBP group. All patients (four of four) in the NBP group who underwent occlusion lasting 10 minutes or longer suffered an infarction versus five of 23 patients in the IVBP group (p < 0.0001). Patients with multiple aneurysms were found to be at increased risk of developing focal infarction, whereas those treated with intermittent temporary clip application were at decreased risk. It is concluded that patients in whom focal iatrogenic ischemia is induced during MCA aneurysm clip ligation have a significant advantage compared with those receiving isoflurane when they are given pentobarbital as the primary neuroprotective agent or when they receive propofol or etomidate titrated to achieve electroencephalographic burst suppression, particularly if more than 10 minutes of occlusion time is required. It is also concluded that 10 minutes is a general guideline for safe, temporary occlusion of the MCA. The use of intermittent temporary arterial occlusion and its use in patients with multiple aneurysms need further evaluation before specific recommendations can be made.
Asunto(s)
Arterias Cerebrales/cirugía , Infarto Cerebral/prevención & control , Aneurisma Intracraneal/cirugía , Fármacos Neuroprotectores/uso terapéutico , Anestesia Intravenosa , Anestésicos por Inhalación/administración & dosificación , Anestésicos Intravenosos/administración & dosificación , Aneurisma Roto/cirugía , Isquemia Encefálica/diagnóstico por imagen , Isquemia Encefálica/etiología , Isquemia Encefálica/prevención & control , Infarto Cerebral/diagnóstico por imagen , Infarto Cerebral/etiología , Circulación Cerebrovascular , Constricción , Electroencefalografía/efectos de los fármacos , Etomidato/administración & dosificación , Femenino , Humanos , Enfermedad Iatrogénica , Ataque Isquémico Transitorio/diagnóstico por imagen , Ataque Isquémico Transitorio/etiología , Ataque Isquémico Transitorio/prevención & control , Isoflurano/administración & dosificación , Masculino , Microcirugia , Persona de Mediana Edad , Pentobarbital/administración & dosificación , Propofol/administración & dosificación , Radiografía , Estudios Retrospectivos , Factores de Riesgo , Hemorragia Subaracnoidea/cirugía , Factores de TiempoRESUMEN
A reversible middle cerebral artery occlusion was performed in rats to determine whether nicardipine, a dihydropyridine voltage-sensitive Ca++ channel (VSCC) antagonist, exerts neuroprotective effects when administered 10 minutes following an ischemic insult, and if it does, whether this is due to its vasodilatory action and effect on cerebral blood flow (CBF) or to direct blockade of Ca++ entry into ischemic brain cells. An increase in the intracellular calcium, [Ca++]i, plays a major role in neuronal injury during cerebral ischemia. Although a large amount of Ca++ enters neurons through the VSCC during ischemia, inconsistent neuroprotective effects have been reported with the antagonists of the VSCC. An intraperitoneal injection of nicardipine (1.2 mg/kg) was administered to rats 10 minutes after the onset of ischemia, and 8, 16, and 24 hours after occlusion. Cortical CBF was determined by laser-Doppler flowmetry. Neurological and neuropathological examinations were performed after 72 hours. Neuron-specific enolase, a specific marker for the incidence of neuronal injury, was measured in plasma. The CBF and other physiological parameters were not affected by nicardipine during occlusion or reperfusion. However, nicardipine treatment significantly improved motor neurological outcome by 29%, and the infarction and edema volume in the pallium as well as the edema volume in the striatum were significantly reduced by 27%, 37%, and 52%, respectively. Nicardipine also reduced the neuron-specific enolase plasma levels by 50%, 42%, and 59% at 24, 48, and 72 hours after the occlusion, respectively. It is concluded that nicardipine may attenuate focal ischemic brain injury by exerting direct neuroprotective and antiedematous effects that do not depend on CBF.
Asunto(s)
Infarto Cerebral/prevención & control , Ataque Isquémico Transitorio/enzimología , Nicardipino/farmacología , Fosfopiruvato Hidratasa/sangre , Daño por Reperfusión/prevención & control , Vasodilatadores/farmacología , Animales , Infarto Cerebral/enzimología , Infarto Cerebral/etiología , Infarto Cerebral/fisiopatología , Circulación Cerebrovascular/efectos de los fármacos , Modelos Animales de Enfermedad , Ataque Isquémico Transitorio/fisiopatología , Masculino , Actividad Motora/efectos de los fármacos , Nicardipino/uso terapéutico , Ratas , Ratas Sprague-Dawley , Daño por Reperfusión/enzimología , Daño por Reperfusión/etiología , Daño por Reperfusión/fisiopatología , Factores de Tiempo , Vasodilatadores/uso terapéuticoRESUMEN
Aneurysms arising from the posterior circulation, especially when they are large and complex, continue to present a technical challenge. The development of cranial base strategies and principles has added to surgical management options. The authors used one of four cranial base approaches for the treatment of 30 patients with large and/or complex aneurysms arising from the vertebrobasilar circulation. These approaches included the extradural temporopolar, combined petrosal, retrolabyrinthine-transsigmoid, and the extreme-lateral inferior transtubercular exposure. The indications, technique, and results of each approach in this series are discussed, and a management paradigm is suggested for such aneurysms.