Psychological, endocrine, and neural correlates of attentional bias in subclinical depression.

BACKGROUND: Our knowledge with respect to psychological, endocrine, and neural correlates of attentional bias in individuals with high vulnerability to developing depression - the subclinically depressed, still remains limited. DESIGN: The study used a 2 × 2 mixed design. METHODS: Attentional bias toward happy and sad faces in healthy (N = 26) and subclinically depressed individuals (N = 22) was assessed via a neuroimaging dot-probe attention task. Participants also completed trait and state psychological measures and provided saliva samples for cortisol analysis. RESULTS: The subclinical group showed attentional bias toward happy faces; past use of problem-focused coping strategies when dealing with a personally relevant stressor as well as state levels of anxiety, together, contributed to this bias. In the control group, the happy attentional bias was positively correlated with activity in the right caudate. In the subclinical group, the bias was negatively associated with the left fusiform gyrus and positively with the left inferior parietal lobule and bilateral putamen. We observed group differences in association between cortisol levels during the task and neural activity during happy attentional bias processing within the key regions involved in attention. CONCLUSIONS: The attentional bias toward happy faces may reflect an active coping attempt by the subclinical participants.

Retrieval-induced forgetting is associated with increased positivity when imagining the future.

People often think of themselves and their experiences in a more positive light than is objectively justified. Inhibitory control processes may promote this positivity bias by modulating the accessibility of negative thoughts and episodes from the past, which then limits their influence in the construction of imagined future events. We tested this hypothesis by investigating the correlation between retrieval-induced forgetting and the extent to which individuals imagine positive and negative episodic future events. First, we measured performance on a task requiring participants to imagine personal episodic events (either positive or negative), and then we correlated that measure with retrieval-induced forgetting. As predicted, individuals who exhibited higher levels of retrieval-induced forgetting imagined fewer negative episodic future events than did individuals who exhibited lower levels of retrieval-induced forgetting. This finding provides new insight into the possible role of retrieval-induced forgetting in autobiographical memory.