RESUMEN
BACKGROUND: The role of apoptosis, and more specifically the Fas pathway, is still unclear in squamous cell laryngeal cancer. MATERIALS AND METHODS: By means of immunohistochemistry, the expression of three genes involved in different pathways of apoptosis (p53, Bcl-2 and Fas) was studied in a series of 45 squamous cell laryngeal cancers from Spanish patients. RESULTS: Of the studied tumors, 25 (55.6%) expressed mutant p53, 22 (48.9%) expressed Bcl-2 and 25 (55.6%) expressed Fas. p53, Bcl-2 and Fas expression were not correlated with each other. The only tested factors associated with significantly better survival of the patients were low tumor stage (p = 0.0074), the absence of metastatic regional nodes (p = 0.0009) and Fas expression (p = 0.029). Fas expression was not correlated with the expression of any other tested parameter. CONCLUSION: The determination of Fas expression in squamous cell laryngeal carcinoma by means of immunohistochemistry using the GM30/CD95 antibody could be of potential use in the clinic.
Asunto(s)
Carcinoma de Células Escamosas/metabolismo , Neoplasias Laríngeas/metabolismo , Receptor fas/biosíntesis , Adulto , Anciano , Anciano de 80 o más Años , Apoptosis/fisiología , Carcinoma de Células Escamosas/patología , Humanos , Inmunohistoquímica , Neoplasias Laríngeas/patología , Metástasis Linfática , Persona de Mediana Edad , Estadificación de Neoplasias , Pronóstico , Proteínas Proto-Oncogénicas c-bcl-2/biosíntesis , Tasa de Supervivencia , Proteína p53 Supresora de Tumor/biosíntesisRESUMEN
El carcinoma ductal in situ CDIS representa entre el 0 y el 7% de los cánceres de mama diagnosticados en varones. El carcinoma papilar intraquístico (CPI) no invasivo es una de las formas de CDIS, y por tanto una presentación extraordinariamente infrecuente de cáncer de mama. La ecografía es la técnica de imagen que mayor información aporta en el estudio de estas lesiones. El tratamiento de los casos de CDIS en varones continúa siendo un tema controvertido. Presentamos un caso de carcinoma intraquístico no invasivo de mama tratado con mastectomía parcial seguida de radioterapia y tratamiento con tamoxifeno. Sin signos de recidiva tras un año de seguimiento (AU)
Ductal carcinoma in situ (DCIS) represents between 0% and 7% of breast cancers diagnosed in men. Noninvasive intracystic papillary carcinoma is a form of DCIS and is therefore an extremely rare presentation of breast cancer. The imaging technique that provides the greatest information on these lesions is ultrasonography. Treatment of DCIS in men continues to be controversial. We present a case of noninvasive intracystic papillary carcinoma treated with partial mastectomy followed by radiotherapy and tamoxifen therapy. After 1 year of follow-up, the patient shows no signs of recurrence (AU)
Asunto(s)
Masculino , Persona de Mediana Edad , Humanos , Carcinoma Papilar/diagnóstico , Carcinoma Papilar/terapia , Carcinoma Ductal/cirugía , Tamoxifeno/uso terapéutico , Inmunohistoquímica/métodos , Biopsia con Aguja/métodos , Recurrencia Local de Neoplasia/diagnóstico , Neoplasias de la Mama Masculina/complicaciones , Neoplasias de la Mama Masculina/diagnóstico , Neoplasias de la Mama Masculina/cirugía , Carcinoma Papilar/complicaciones , Carcinoma Ductal/diagnóstico , Carcinoma Papilar , Mastectomía/métodos , Diagnóstico Diferencial , Mamografía/métodos , Tomografía Computarizada de Emisión/métodos , Neoplasias de la Mama Masculina/tratamiento farmacológico , Neoplasias de la Mama Masculina/radioterapiaRESUMEN
Ductal carcinoma in situ (DCIS) represents between 0% and 7% of breast cancers diagnosed in men. Noninvasive intracystic papillary carcinoma is a form of DCIS and is therefore an extremely rare presentation of breast cancer. The imaging technique that provides the greatest information on these lesions is ultrasonography. Treatment of DCIS in men continues to be controversial. We present a case of noninvasive intracystic papillary carcinoma treated with partial mastectomy followed by radiotherapy and tamoxifen therapy. After 1 year of follow-up, the patient shows no signs of recurrence.