RESUMEN
RationaleThe impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. ObjectivesTo assess outcomes following COVID-19 in patients with ILD versus those without in a contemporaneous age, sex and comorbidity matched population. MethodsAn international multicentre audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. Measurements and Main ResultsData from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and comorbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of <80% had an increased risk of death versus patients with FVC [≥]80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 1.98, 1.13-3.46). ConclusionsPatients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD.
RESUMEN
A hanseníase é uma doença crônica, infectocontagiosa, causada pelo bacilo de Hansen (Mycobacterium leprae), que acomete peles e nervos periféricos, com alto poder incapacitante e forte estigma social, provocando um sofrimento aos seus portadores, para além de seus sintomas físicos. Tendo os indicadores sociais um papel determinante nesse processo, objetivou-se traçar o perfil socioeconômico dos pacientes atendidos pelo Centro de Referência em Reabilitação da Hanseníase da Zona da Mata Mineira. Para tanto, foram analisados 99 prontuários e suas respectivas fichas de abordagem social, dos usuários atendidos de janeiro de 2004 a junho de 2011. Os resultados apontam o predomínio de pacientes do sexo masculino (54,5%), advindos de áreas urbanas (84,8%), com baixa escolaridade (54,5%) e renda familiar igual ou inferior a dois salários mínimos (60,6%), em faixa etária que compreende a população economicamente ativa, residindo em casa própria (69,7%), com infraestrutura adequada (73,7%), porém convivendo com uma média de quatro ou mais pessoas neste mesmo espaço (24,2%). Tais resultados demonstram que os protocolos de intervenções clínicas devem integrar-se às medidas de melhoria das condições de vida da população para uma efetiva política de controle da doença, uma vez que sua ocorrência está diretamente relacionada às desigualdades sociais existentes.
Leprosy is a chronic disease, infectious contagious, caused by bacillus Mycobacterium leprae, that affects skins and peripheral nerves, with a high power disabling and strong social stigma, promoting suffering to patients beyond their physical symptoms. As the social indicators a key role in this process, it was aimed to trace the socioeconomic profile of the patients attended at the Reference Center for Rehabilitation of Leprosy of the Southeast of Minas Gerais State. For that, 99 patients records and their respective social approach files, from patients attended between January 2004 and June 2011, were analyzed. The results indicate most of men (54.5%), from urban areas (84.8%) with low education level (54.5%) and a familiar income equal to or less than two minimum wages (60,6%), in economically active age group, living in own home (69.7%) with a suitable infrastructure (73.7%) but living with an average of four or more people in the same house (24.2%). These results show that measures to improve people's living conditions should be integrated into clinical protocol interventions, for an effective disease control policy, since its occurrence is directly related to the existing social differences.
