[Correlation of glycosylated hemoglobin and fructosamine in pregnant women with diabetes mellitus]. / Korelacija glikolizovanog hemoglobina i fruktozamina kod trudnica s dijabetesom melitusom.

Glycolisated hemoglobin (HBA1c), fructosamine, glucose, albumin and total proteins were estimated 40 healthy pregnant women and 90 pregnant women with diabetes mellitus. Fructosamine was estimated by NBT method with "Fructosamine test" commercially available kit on Technicom automatic analyser RA-1000. Glucose was determined on Beckmman glucose analyser. HBA1c was assayed by Bio-Rad test, while albumin and total proteins by Beckmman tests. We found best correlation between fructosamine and HBA1c at pregnant women who were on dietary therapy worst at pregnancy women on insulin therapy.

The estimation of fructosamine and HbAlc in pregnant women with diabetes mellitus.

Fructosamine, HbAlc, glucose, albumins and total proteins were estimated in 40 healthy pregnant women and 80 pregnant women with insulin dependent diabetes mellitus. Fructosamine was estimated by the NBT method with "Fructosamine test" commercially available kit on Technicom automatic analyser RA-1000. Glucose was determined on Beckman glucose analyser. HbAlc was assayed by the Bio-Rad test, while albumin and total proteins by Beckman tests. For all estimated parameters no significant differences were found between healthy pregnant women and pregnant women with insulin dependent diabetes mellitus.

[Wilson's disease and pregnancy]. / Vilsonova bolest i trudnoca.

Wilson's disease is rare autosomal-recessive disorder originated on the basis of metabolic copper over-storage. This is the case report of patient aged 28, who suffers Wilson's disease during last ten years. She has been treated by penicillamine unregularly from the beginning of her disease. She reported three spontaneous abortions in her previous history. She was treated by penicillamin and bedoxin in current pregnancy. Vaginal delivery was completed using oxytocin stimulation. Newborn was male, alive, with body weight of 2900 grams. Apgar score was 8. During puerperal period normal uterine involution was estimated, but lactation was ceased.

[Etiological factors in sterility and infertility as risk factors in future pregnancies]. / O nekim etioloskim ciniocima steriliteta i infertiliteta kao faktorima rizika u buducim trudnocama.

An analysis was made of 1420 patients with threatened spontaneous or habitual abortions and pre-term deliveries, concerning the incidence of some etiological factors of infertility that might have been risk factors in the actual pregnancy. The number of pregnant women over 35 years of age in the treated series was significantly higher than in the control group. History data on sterility in the former group showed the incidence of 4.37% and in the control group 1.10%, the difference being highly significant (P less than 0.001). In the investigated series 154 patients (10.85%) had already had previous pre-term deliveries, while in the control group pre-term deliveries amounted to 3.20%, the difference being statistically highly significant (P less than 0.001). History data on spontaneous abortions in the first group showed the incidence of 69.57% (846 patients) and in the control group 16.20% (P less than 0.001). Uterine malformations were recorded in 69 gravidae (4.86%) in the treated group and in 1.20% in the control group, the difference being statistically highly significant (P less than 0.001). In addition to etiological factors, a high incidence of the following anomalies was also revealed: uterine hypoplasia and myoma, cervical laceration, cervico-isthmical insufficiency, and perinatal deaths in the history of the treated group. The importance of antenatal care of pregnant women with previous sterility and infertility is emphasized, as well as the need for considering the prophylactic use of beta-sympathomimetics.

[Hemolytic disease of the newborn in monozygotic twins caused by anti-c alloantibodies of the rhesus system]. / Morbus haemolyticus neonatorum u jednojajnih blizanaca uzrokovan anti-c aloantitelima rhesus sistema.

The aloimunisation of the pregnant woman has been showed as hard form Morbus Haemolyticus Neonatorum (MHN) Newborn twins. Prematurely born twins - monoegged and their mother have compatible blood group of ABO system (A). CC-fenotype exchange transfusion was given to one child while the other received blood of cc-fenotype later on, the both of them were given additional transfusion of CC-fenotype of corresponding blood group ABO. Mother was given CC-fenotype blood transfusion. Certain difference was seen in the fostness of restituciones of the value of hematocrit in the fostness of value normalizations of bilirubin and in the presence of anti c antibodies in red cells and in the sera of sick twins. The comparisons of the MHN course are limited by the fact that Newborn twins have neither of the same level of imperillness during the term of birth, nor of same fisiological characteristics. Six weeks after being born and after clinical treatment, the children were found health and to domestic treatment.

[Hemolytic disease of the newborn due to anti-S-antibodies]. / Hemoliticka bolest novorodenceta uzrokovana anti-S antitelima.

In the serum of S-negative secundi para woman a specific anti-S agglutinin of the IgG type was identified. The same agglutinin was identified in the serum and on the eritrocytes of the newborn with sympthomes of a light Hemolytic disease. Exchange transfusion was not necessary. The anti-S described is an immune warm agglutinin showing the efect of dose and is discovered only by the Coombs technique.

[Correlation between the presence of cytotoxic anti-HL-A antibodies in the clinical course of hemolytic disease of the newborn infant due to anti-Rh (D) or immune anti-A/B erythrocyte antibodies]. / Korelacija izmedu prisustva citotoksicnih anti-HL-A antitela i klinickog toka hemoliticke bolesti novorodencadi uzrokovane anti-Rh-(D) ili imunim anti-A/Beritrocitnim antitelima

In a retrospective study the simultaneous influence of catotoxic HL-A antibodies on the clinical course of 60 cases of infants affected by Haemolytic disease on the Newborn due to anti Rh (D) or immune anti A/B antibodies, is shown. In all cases the treatment was by exange transfusion. In the group of infants in whose cord blood anti HL-A antibodies were found Exange transfusion had a weak efect so that it had to be repeated in 96 per cent of cases. In the group of infants in whose cord blood anti HL-S antibodies were not found, Exange transfusion was repeated only in one case, that is 2,7 per cent. In a group of Rh isommunised mothers whose children were affected by Haemolytic disease of the Newborn, antt HL-A antibodies were found in 61,7 per cent while 80,5 per cnet of the antibodies passed through the placente. In a group of ABO isoimmunised mothers cytotoxic HL-A antibodies were found in 42,3 per cent, while 45,4 per cent passed through the placente. A significant difference in the number of leucocytes, limphocytes, platelets, term of birth, level of bilirubin, amount of haemoglobin and Apgar Score was not found between the group of newborn who in their cord blood had, besides the already present isoimmunhaemagllutinines, cytotoxic HL-A antibodies and the group of infants with no cytotoxic anti HL-A antibodies, present. Cytotoxic HL-A antibodies in a way, react with the "unmasked" erythrocyte membrane, increasing haemolysis, so that the therapeutic effect of Exange transfusion was discriminated.

[Interference of erythrocyte blood groups on the mother-fetus relationship and distribution of anti-HL-A antibodies in the newborn infant]. / Interferenca eritrocitnih krvnih grupa na relaciji majka--plod i delovanja materinskih anti-HL-A antitela na novorodence

One hundred and eighty eight pairs of mother--newborn was examinated. Cytotoxic anti-HL-A antibodies were found in 21% of mothers and 16, 5% of newborns. In 70% the mother's anti-HL-A antibodies passed in the foetus circulation. Authors did not found the damage of the foetus connected with the presence of anti-HL-A antibodies. We did not observe the corellation between the compatibility of antigens ABO and Rh Blood groups of mother and foetus, and the apparence of cytotoxic anti-HL-A antibodies. In the paiss A-B and O-B cytotoxic anti HL-A antibodies were present in significant high percent.