1.
Can J Neurol Sci
; 25(3): 249-51, 1998 Aug.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9706728
RESUMEN
OBJECTIVE: Previous studies demonstrated controversial results regarding monoamine oxidase B (MAO-B) activity in platelets in the periphery in parkinsonian patients (PD). SUBJECTS AND METHODS: Therefore we determined platelet MAO-B activity in three age- and sex-matched groups of 17 untreated, so called "de novo" patients with Parkinson's disease (PD), 17 parkinsonian patients, receiving levodopa, and 17 controls by a radio enzymatic assay. RESULTS: No significant differences of MAO-B activity appeared. CONCLUSION: This result suggests that phenotypic determination of MAO-B activity in platelets may not be used as peripheral marker in PD and that levodopa treatment does not alter MAO-B activity in the periphery.
Asunto(s)
Antiparkinsonianos/uso terapéutico , Plaquetas/enzimología , Levodopa/uso terapéutico , Monoaminooxidasa/sangre , Enfermedad de Parkinson/sangre , Enfermedad de Parkinson/tratamiento farmacológico , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Fenotipo
2.
Toxicol Appl Pharmacol
; 14(3): 457-68, 1969 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-5787515
3.
Bull Environ Contam Toxicol
; 3(5): 302-8, 1968 Sep.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24185307
4.
Am J Pathol
; 50(2): 361-9, 1967 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-6016511