[Prevention and correction of cognitive dysfunction after general anesthesia]. / Profilaktika i korrektsiia kognitivnykh narushenii posle obshchei anestezii.

AIM: To evaluate clinical efficacy of intraoperative use of cytoflavin in the prevention and correction of cognitive functions in surgical patients with no history of neurological and psychosomatic disorders. MATERIAL AND METHODS: The study included 60 female patients who underwent surgery on the thyroid gland. Patients were stratified into two equal groups matched for main indices. Patients of the main group received infusions of cytoflavin (20 ml in 200 ml of 5% glucose solution). Patients underwent thyroidectomy with general inhalation anesthesia using desflurane. Cognitive testing was performed one day before operation and 6, 24 and 48 h after. Waking time after stopping desflurane administration and time prior tracheal extubation were recorded. RESULTS AND CONCLUSION: The use of cytoflavin promoted the early post anesthesia adaptation and more rapid recovery of initial cognitive status of the patients.

First cage-like pentanuclear Co(ii)-silsesquioxane.

A new pentanuclear "cylinder"-like cobalt(ii) phenylsilsesquioxane [(PhSiO1.5)10(CoO)5(NaOH)] exhibits a slow relaxation of the magnetization and a high catalytic activity and stereoselectivity in the oxidation of alkanes and alcohols.

Two pathways of proton transfer reaction to (triphos)Cu(η(1)-BH4) via a dihydrogen bond [triphos = 1,1,1-tris(diphenylphosphinomethyl)ethane].

The interaction of the η(1)-tetrahydroborate copper(i) complex (triphos)Cu(η(1)-BH4) () with proton donors [CF3CH2OH (TFE), (CF3)2CHOH (HFIP), (CF3)3COH (PFTB), PhOH, p-NO2C6H4OH (PNP), p-NO2C6H4N[double bond, length as m-dash]NC6H4OH (PNAP), CF3OH] was a subject of a combined IR spectroscopic and theoretical investigation. Spectral (Δν) and thermodynamic (ΔH) parameters of dihydrogen bond (DHB) formation were determined experimentally. The terminal hydride ligand (characterized by the basicity factor Ej(BH) = 0.87 ± 0.01) is found to be a site of proton transfer which begins with nucleophilic substitution of BH4(-) by the alcohol oxygen atom on the copper center (BH pathway). The activation barrier computed for (CF3)2CHOH in CH2Cl2 - ΔG = 20.6 kcal mol(-1) - is in good agreement with the experimental value (ΔG = 20.0 kcal mol(-1)). An abnormal dependence of the reaction rate on the proton donor strength found experimentally in dichloromethane is explained computationally on the basis of the variation of the structural and energetic details of this process with the proton donor strength. In the second reaction mechanism found (CuH pathway), DHB complexes with the initial ROH coordination to the bridging hydride lead to B-Hbr bond cleavage with BH3 elimination. "Copper assistance" via the CuO interaction is not involved. This mechanism can be evoked to explain the occurrence of proton transfer in coordinating solvents.

[TREATMENT OF SEVERE INTRAPATUM ASPHYXIA.]

THE AIM: Estimate of efficiency of newborns with severe birth asphyxia treatment using systemic therapeutic hypothermia. MATERIALS AND METHODS: a retrospective open-controlled clinical research with a resolution of the Ethics;Committee performed in 33 neonates born in asphyxia and treated at the NICU All newborns due to the presence of indications, overall controlled hypothermia was conducted according to the approved protocol, using the apparatus Allon 2001". RESULTS: The neurological status at admission: Sarnat II was detected in 60.6% (20) children; Sarnat III was detected in 39.4% (13) children. The correlation ofApgar scores with the most severe hypoxic ischemic encephalopathy. Pupillary reflexes admission absent in 48.5% (16) newborns. Convulsions within first hours of lfe were observed in 57.6% (19) newborns. Convulsions within I day of life were observed in 81.8 % (27) newborns. The correlation of the amniotic infection (AI) and meconium aspiration syndrome (MAS) treatment using high-frequency mechanical ventilation (p<0,05) and prolongation of mechanical ventilation for more than 5 days (p<0,01). At the beginning of systemic hypothermia fraction of inspired oxygen (FiO2), mean airway pressure (MAP), respiratory rate (RR) were down to the 12th hour of life and reaches a minimum at the end of the third day. These trends have been observed in children with MAS. The correlation of the use of high-frequency mechanical ventilation using high doses ofcardiotonics and the transition to the infusion of epinephrine or norepinephrine (p <0.01).There were no deaths in the studying group. CONCLUSIONS: 1. Reliable predictor of the clinical outcomes severity of hypoxic-ischemic encephalopathy (HIE) by the end of the first month lf is the presence of convulsions within the first hour of lf (p<0. 03). 2. When comparing the evaluation on Apgar scale with the data of acid-base balance and severity of HIE a significant correlation between the estimation at the first minute is I point and at the fifth minute 3 point and more severe pH shift, base deficiency, hyperlactatacidosis and severe HIE. 3. MAS and AI are the most frequent accompanying diseases that complicates the severity of newborn status causing prolonged artificial ventilation and the infusion ofcardiotonics. 4. There is a decrease in all parameters of artficial lung ventilation to the twelfth hour life in early systemic hypothermia and reached minimum by the end of the third day.

[COGNITIVE ABNORMALITIES IN POSTOPERATIVE PERIOD OF THYROID SURGERY].

An evaluation of cognitive functions was presented in 90 patients undergoing thyroid surgery. An attention deterioration, shot-term memory impairment and degradation were revealed after operation. It was shown that reduction of manifestations of cognitive dysfunction and stabilization of the haemodynamics indices were allowed due to application of cytoflavin during operation and in early postoperative period.

[Prevention of cognitive dysfunction in patients operated on thyroid gland].

The cognitive functions assessment in 68 patients operated on thyroid gland is presented. It is elicited that attention decrease, short-term memory upset, depressed work-capacity develop after intervention. It is shown that cytoflavin use within the intervention and early postoperative period permit to decrease cognitive dysfunction signs.

Toward the subdiffraction focusing limit of optical superresolution.

A superresolving three-zone plate is applied to a Fresnel diffractive lens. It is shown that for radial incident polarization this combination produces a focal spot approaching superresolution allowed subdiffractive limit of 0.36lambda/NA for focusing. For media responsive to longitudinal field component only, our phase engineering scheme results in a focal spot size of 0.368lambda/NA. When used with a solid immersion lens, the scheme can generate the smallest focal spot available for passive optics.

Distributed exponential enhancement of phase sensitivity and intensity by coupled resonant cavities.

It is shown that coupled Gires-Tournois interferometers or mathematically equivalent ring resonators exhibit distributed exponential enhancement of the phase shifts of the cavities and of the intensity of the incident wave. For identical coupled elements, this leads to a resonant increase in intensity and linear phase sensitivity in any cavity of the chain by a factor of single resonator finesse to the power of the order of this cavity, n, and also leads to an increase in sensitivity to nonlinear optical phase by finesse to the power of 2n.

[Multimodal antinociceptive management of patients with ileus in surgery]. / Multimodalnaia antinotsitseptivnaia zashchita u bol'nykh s ostroi kishechnoi neprokhodimost'iu.

Acute ileus has been for years a topical problem in abdominal surgery. Successful surgical treatment with the pathology depends not only on a surgical scheme but also on the efficiency of anesthetic management. The purpose of the present case study was to investigate issues related with appropriate anesthesia for elderly and senile patients in ileus surgery. General analgesia with sodium oxibutiratis, ketamine and phentanil, when combined with epidural anesthesia with ropivaciane, provides for an adequate anesthetic management of elderly and senile patients in ileus surgery.

[Modulated kinesitherapy in rehabilitation of patients with cardiovascular diseases]. / Modulirovannaia kineziterapiia v reabilitatsii bol'nykh s zabolevaniiami serdechno-sosudistoi sistemy.

Modulated kinesitherapy (MK) is a new method based on synchronization of vegetative and motor components in walking at a pace corresponding to actual heart rate which is maintained during the procedure with cardiotrainer Marafon. MK produced the following therapeutic effects: optimization of cardiovascular functions (weakening of postload on the heart with lowering of arterial pressure; improvement of coronary blood flow, stabilization of the heart rate and cardiac pump function); marked antiarrhythmic effect, normalization of autonomic nervous system tonicity, neurohumoral and psychoemotional state. MK is indicated in ischemic heart disease, essential hypertension, cardiac arrhythmia, vegetovascular asthenia.

Polarization splitter/combiner in high index contrast Bragg reflector waveguides.

Novel designs of polarization devices based on Bragg reflector waveguides in a high index contrast silicon-on-insulator (SOI) platform have been proposed. Brewster angle condition is incorporated in the periodic structures. Numerical simulations with a 3D semivectorial beam propagation method demonstrate the device performance as TE mode polarizer with high TE to TM extinction ratio and TE/TM mode polarization splitter and combiner with high polarization splitting efficiency.

pi-shifted Sagnac interferometer for characterization of femtosecond first- and second-order polarization mode dispersion.

A novel configuration for measuring femtosecond polarization mode dispersion (PMD) with a pi-shifted Sagnac interferometer is studied. The advantages of this configuration include a response that is independent of the orientation of the device under test. This independence allows characterization of the first-and second-order PMD by measurement of the wavelength dependence of the differential group delay and of the orientation of the device's principal states of polarization. The method provides an extension of the dynamic range of the Sagnac interferometer technique to few-femtosecond PMD measurement.

Superluminal-source-induced emission.

Raman emission by an axicon-generated superluminal source is demonstrated. The anti-Stokes radiation is emitted at an angle defined by a Cerenkov-type condition. This technique of superluminal-source generation has advantages in both low pump self-phase modulation and compensation of temporal walk-off caused by group-velocity dispersion, rendering the scheme useful for efficient Raman conversion, pump-probe measurements, and harmonic and optical parametric generation with ultrashort intense pulses.

[Effects of different types of general anesthesia on metabolic activity of erythrocytes]. / Vliianie razlichnykh vidov obshchei anestezii na metabolicheskuiu aktivnost' éritrotsitov.

The effect of general anesthesia with ether, azeotropic mixture and drugs for neuroleptanalgesia on the activity of glycolytic enzymes and the content of glycolysis metabolites in erythrocytes has been studied in 212 patients with II to IV stage gastric cancer. It has been shown that ether anesthesia and anesthesia with azeotropic mixture aggravate metabolic disturbances, while neuroleptanalgesia has no negative effect on cellular metabolism. The absence of correlation between the severity of surgical intervention and the degree of disturbances in erythrocyte metabolism indicates a sufficient anesthesiological protection when drugs for neuroleptanalgesia are used.

Nonlinear refraction in CS(2) at 10.6 microm.

The nonlinear refractive index n(2) of CS(2) at 10.6 microm, the value of which is a subject of a recent controversy, is measured by an external self-focusing method. We found that n(2) = (2.1 +/- 0.7) x 10(-11) esu, similar to the accepted value of n(2) in the visible. Self-bending of spatially asymmetric CO(2) laser beam in CS(2) due to an ultrafast Kerr effect is observed, and the deduced value of n(2) is in agreement with our results.