[Regulatory properties of the rat heart adenylate cyclase in the course of toxic-infective shock caused by Yersinia pestis]. / Reguliatornye svoistva adenilattsiklazy serdtsa krys v dinamike chumnogo toksiko-infektsionnogo shoka.

Influence of intravenously administered to rats murine toxin of Y. pestis in the dose of I mg/ml (LD100) on the regulatory properties of heart plasma membranes adenylate cyclase (AC) has been studied during the intoxication. It has been shown that basal, fluoride,- and 5-guanylyl imidodiphosphate-stimulated AC activity remained unchanged during the intoxication. Stimulation of AC by isoproterenol, glucagon and histamine did not change during the first two hours and significantly decreased after 5 hours of intoxication. Affinity of AC for the investigated hormones did not change through the experiments.

[Potential-dependent Ca2+ channels and contractile function of the heart in toxic-infectious shock caused plague]. / Potentsialzavisimye Ca2+-kanaly i sokratitel'naia funktsiia serdtsa v dinamike chumnogo toksiko-infektsionnogo shoka.

Influence of intravenous administration to rats of murine toxin of Y. pestis (1 mg/ml, LD100) on the number of potential-operated Ca(2+)-channels, alpha- and beta-adrenergic and M1-cholinergic receptors of plasma membranes and heart contractility function has been studied in rats. The number of Ca(2+)-channels in plasma membranes and contractility of heart decreased by 50% in 1 hour after the i.v. administration of toxin and further decreased up to the lethal end. During the agonal stage of the shock desensitization of beta-adrenergic receptors has been discovered, while alpha-adrenergic and M1-cholinergic receptors remained unchanged throughout the experiments.