Asunto(s)
Antígenos de Neoplasias/administración & dosificación , Inmunoterapia/métodos , Melanoma/secundario , Proteínas de Neoplasias/administración & dosificación , Neoplasias Cutáneas/secundario , Vacunas/administración & dosificación , Humanos , Melanoma/terapia , Antígenos Específicos del Melanoma , Neoplasias Cutáneas/terapiaAsunto(s)
Melanoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Adulto , Factores de Edad , Anciano , Austria , Femenino , Estudios de Seguimiento , Humanos , Masculino , Melanoma/epidemiología , Melanoma/patología , Persona de Mediana Edad , Metástasis de la Neoplasia , Pronóstico , Factores Sexuales , Neoplasias Cutáneas/epidemiología , Neoplasias Cutáneas/patologíaAsunto(s)
Serodiagnóstico de la Sífilis/métodos , Adulto , Femenino , Humanos , Inmunoglobulina A/análisis , Inmunoglobulina D/análisis , Inmunoglobulina E/análisis , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Inyecciones Intramusculares , Masculino , Persona de Mediana Edad , Penicilinas/administración & dosificaciónAsunto(s)
Inmunoglobulina E/análisis , Adolescente , Adulto , Niño , Eccema/diagnóstico , Humanos , Hipersensibilidad/diagnóstico , Neurodermatitis/diagnóstico , Prueba de Radioalergoadsorción , Prueba de Radioinmunoadsorción , Investigación , Hipersensibilidad Respiratoria/diagnóstico , Formación de Roseta , Pruebas CutáneasAsunto(s)
Proteínas Sanguíneas/análisis , Inmunoglobulina E/análisis , Neoplasias/inmunología , Adulto , Anciano , alfa-Globulinas/análisis , beta-Globulinas/análisis , Femenino , Humanos , Inmunoglobulinas/análisis , Masculino , Persona de Mediana Edad , Albúmina Sérica/análisis , alfa-Macroglobulinas/análisis , gammaglobulinas/análisisRESUMEN
Influence of autologous serum on cellular immunological reactivity to melanomalignoma (MM)-associated antigens was examined on 20 patients have MM at different clinical stages, using the Leucocyte-Migration-Inhibition-Test (MIT). These 20 patients were referring to this till now not investigated. When heterologous serum (horse serum) was supplemented, an inhibition of cell-migration could be established in 15/20 cases, whereas a cell-migration inhibition in 14/20 cases was absent if autologous serum was added to culture medium. No correlation could be found between our test results and the clinical stage of the disease. Our results suggests urgently that blocking factors are present in serum of MM-patients. There is reason to believe that this factors will be active in lymphocyte level.
Asunto(s)
Inhibición de Migración Celular , Melanoma/inmunología , Neoplasias Cutáneas/inmunología , Adulto , Anciano , Animales , Antígenos de Neoplasias , Femenino , Caballos , Humanos , Sueros Inmunes/farmacología , Linfocitos/efectos de los fármacos , Factores Inhibidores de la Migración de Macrófagos/farmacología , Masculino , Persona de Mediana EdadRESUMEN
In 1966 a new immunoglobulin was found in persons with allergies and in non-typical myeloma proteins. Normally this immunoglobulin E is present only in nanogramms and rests with predilection on the membrane of mast-cells. There is a reaginic-anaphylactic reaction after re-exposure of antigens to the antigen-antibody reaction followed by denudation of mediators of the anaphylactic reaction. With the Radio-Immuno-Sorbent-Test (RIST) the IgE can be quantitatively determined. Elevated IgE-blood levels are typically found in atopic eczema. With the Radio-Allergo-Sorbent-Test (Rast) the allergen specific IgE can be defined. A conformity with appropriate patchtests can be achieved in 60-80% of the cases. In this review advantoses and problem of RIST- and RAST-diagnoses are described. RAST represents a valuable aid in diagnosis of allergies beeing not burdensome and risky, as it is easy to perform and bears no risk to the patients. At the present time, however, patch tests are necessary in the diagnosis of allergies.
Asunto(s)
Hipersensibilidad/diagnóstico , Inmunoglobulina E , Prueba de Radioalergoadsorción/métodos , Radioinmunoensayo/métodos , Adolescente , Adulto , Factores de Edad , Anciano , Reacciones Antígeno-Anticuerpo , Asma/sangre , Niño , Preescolar , Humanos , Hipersensibilidad/sangre , Inmunoglobulina E/análisis , Lactante , Persona de Mediana Edad , Neurodermatitis/sangre , Polen , Reaginas , Rinitis Alérgica Estacional/sangre , Pruebas CutáneasRESUMEN
Cellular immunological reactivity was examined in 20 patients having melanomalignoma at different clinical stages, using Leukocyte-Migration-Inhibition-Test. As antigens three homologous melanoma-extracts were used, produced by our own method. Independent from the clinical stages cell-migration inhibition could be established in 15 out of the 20 patients. In this way, these tumor extracts have been shown to contain melanoma-associated antigens. Regardless of the clinical stage of the disease, the melanomalignomas patient produces cellular immunity against those tumor-antigens. It is note-worthy that the actual course of the disease seems not to be influenced by immun-mechanisms.
Asunto(s)
Inmunidad Celular , Melanoma/inmunología , Neoplasias Cutáneas/inmunología , Adulto , Anciano , Antígenos de Neoplasias/análisis , Inhibición de Migración Celular , Femenino , Humanos , Leucocitos/inmunología , Masculino , Persona de Mediana Edad , Nevo Pigmentado/inmunología , Síndrome , Vitíligo/inmunologíaRESUMEN
Lymphocytes of peripheral blood of patients with systemic lupus erythematosus, scleroderma and dermatomyositis were investigated, and relatively, with regard to T- or B-cell characteristics. T-lymphocytes of most patients with SLE were decreased both absolutely. B-lymphocytes mostly showed only a relative increase. Successful immunosuppressive treatment usually accompanied by normalization of T-cell number and with decrease of B-cells. This differentiation of lymphocytes is an additional aid in the determination of activity of SLE and a useful index of immunosuppressive-cytostatic treatment.
Asunto(s)
Linfocitos B/inmunología , Enfermedades del Colágeno/inmunología , Linfocitos T/inmunología , Anticuerpos Antinucleares/análisis , Proteínas del Sistema Complemento/análisis , ADN/inmunología , Dermatomiositis/inmunología , Humanos , Reacción de Inmunoadherencia , Inmunosupresores/uso terapéutico , Recuento de Leucocitos , Lupus Eritematoso Discoide/inmunología , Lupus Eritematoso Sistémico/tratamiento farmacológico , Lupus Eritematoso Sistémico/inmunología , Receptores de Antígenos de Linfocitos B/análisis , Esclerodermia Localizada/inmunología , Esclerodermia Sistémica/inmunologíaRESUMEN
This report deals with the case of a 50 year-old woman with long-standing scleroderma of the acral-asphyxial type with a relatively slight tendency to progression. Chronic lymphadenosis has been an additional feature of this case over the past few years. The following findings appear of particular interest: autoimmune phenomena in the form of antinuclear antibodies, a virtually monoclonal proliferation of B-lymphocytes and a relative T-lymphocyte deficiency. It is suggested that both conditions may be pathogenetically connected with an immunologically defined insufficiency of the lymphocytic system. Hence, in view of this observation, it may not be correct to consider scleroderma a "paraneoplastic phenomenon".