RESUMEN
Guinea pigs were inoculated intracerebrally with cerebrospinal fluid (CSF) and/or brain tissue suspensions from 8 patients with Creutzfeldt-Jakob disease (CJD) and with CSF from 2 patients with Alzheimer's disease. After a very long incubation period (over 360-420 days) a serially transmissible experimental disease appeared in the guinea pigs inoculated with CSF from 5 of the CJD patients, with either CSF or brain suspension from one CJD patient and with brain suspensions from the remaining 2 CJD patients. The disease was characterized by tremor, ataxia, convulsions and morphopathological lesions, such as spongiform change, glial hyperplasia and vacuolation of the neurons. Inoculations of CSF from the two Alzheimer's disease cases gave negative results.
Asunto(s)
Enfermedad de Alzheimer/transmisión , Síndrome de Creutzfeldt-Jakob/transmisión , Modelos Animales de Enfermedad , Cobayas/microbiología , Enfermedad de Alzheimer/patología , Animales , Encéfalo/patología , Líquido Cefalorraquídeo/citología , Síndrome de Creutzfeldt-Jakob/patología , Factores de TiempoRESUMEN
Prospective and retrospective statistical studies were performed in 1,000 cases of congenital malformations. The incidences and severity of the different types of malformations were correlated with the risk and protection factors having acted on the pregnant woman. The correlation coefficients were higher in the case of specific risk factors, among which special attention was paid to maternal virus infections. The possibility is discussed of developing a programme for the individual protection of high-risk cases, implying the compensation of the exposure to risk factors by the application of adequate protection factors, according to the calculated scores.
Asunto(s)
Anomalías Congénitas/epidemiología , Complicaciones Infecciosas del Embarazo/epidemiología , Virosis/epidemiología , Anomalías Congénitas/etiología , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Embarazo , Estudios Prospectivos , Estudios Retrospectivos , Riesgo , RumaníaRESUMEN
Data are presented on morphological and biochemical cell transformation in vitro induced by HSV. The results of some investigations on the oncogenic potential of different HSV strains, performed in the "Stefan S. Nicolau" Institute of Virology, are also reviewed. Several hypotheses concerning the mechanism of HSV-induced cell transformation in vitro are discussed.
Asunto(s)
Transformación Celular Viral , Virus Oncogénicos , Simplexvirus , Animales , Células Cultivadas , Cricetinae , Embrión de Mamíferos , Técnicas In Vitro , Ratas , Cultivo de VirusRESUMEN
The results obtained in the "Stefan S. Nicolau" Institute of Virology by the study of herpes simplex virus (HSV) are reviewed. The investigations were mainly focused on HSV biology, genetic markers, experimental HSV infection, correlation between HSV and some diseases, action of some chemical and biological preparations on HSV, in vitro and in vivo HSV oncogenicity, HSV-induced surface antigens, a.o.
