1.
Pol J Vet Sci
; 21(2): 409-413, 2018 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30450884
RESUMEN
Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection. The aim of this study was to investigate the effect of matrine on α-hemolysin production of Staphylococcus aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by S. aureus α-hemolysin. Subinhibitory concentrations of matrine decreased the production of α-hemolysin in none dose-dependent manner and matrine exhibited a protective effect on S. aureus-induced BMECs injury. The results indicated that the structure of matrine may potentially be used as a basic structure for development of drugs aimed at curing and preventing dairy bovine mastitis.
Asunto(s)
Alcaloides , Células Epiteliales , Proteínas Hemolisinas , Quinolizinas , Infecciones Estafilocócicas , Staphylococcus aureus , Alcaloides/farmacología , Animales , Bovinos , Células Epiteliales/patología , Femenino , Mastitis Bovina , Quinolizinas/farmacología , Infecciones Estafilocócicas/veterinaria , Staphylococcus aureus/patogenicidad , Matrinas
2.
J Eur Acad Dermatol Venereol
; 24(5): 611-2, 2010 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19793152