RESUMEN
We describe multiple sleep latency test (MSLT) results in 27 adult patients with idiopathic Parkinson's disease (PD). Pathological sleepiness (i.e. mean sleep latency
Asunto(s)
Ritmo Circadiano/fisiología , Trastornos de Somnolencia Excesiva/complicaciones , Enfermedad de Parkinson/complicaciones , Sueño REM/fisiología , Anciano , Nivel de Alerta/fisiología , Trastornos de Somnolencia Excesiva/diagnóstico , Electroencefalografía , Electromiografía , Electrooculografía , Femenino , Humanos , MasculinoRESUMEN
We report a 56-year-old man with Huntington's disease whose chorea substantially improved after treatment with electroconvulsive therapy (ECT). ECT should be considered for medically refractory cases of movement disorders, especially those with severe disability.
Asunto(s)
Terapia Electroconvulsiva , Enfermedad de Huntington/terapia , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The epidermal nevus syndrome (ENS) is an unusual neurocutaneous disorder consisting of the combination of an epidermal nevus and a central nervous system (CNS), ophthalmological, and/or skeletal abnormality. The study reports four new patients with ENS. Each had a confirmatory biopsy of the epidermal nevus, abnormal neurological examination findings, and documented CNS anatomical studies by imaging or autopsy. The paper also reviews the literature in English to determine neurological abnormalities found in skin-biopsy-proven cases of ENS. Hemi-atrophy, hemimegalencephaly, migrational abnormalities and vascular anomalies were found to be the most frequent intracranial abnormalities associated with ENS. Seizures and/or disabling moderate to severe developmental delays were present in a majority of patients. Seizure onset during the neonatal period or early infancy was associated with major hemispheric malformations. Neuroectodermal-derived ocular lesions were often bilateral. No consistent relation between laterality of the nevus and laterality of CNS abnormalities was found, supporting the gene mosaicism theory of pathogenesis.
Asunto(s)
Anomalías Múltiples , Sistema Nervioso Central/anomalías , Nevo Pigmentado/patología , Neoplasias Cutáneas/patología , Encéfalo/patología , Femenino , Humanos , Recién Nacido , Imagen por Resonancia Magnética , Masculino , Nevo Pigmentado/congénito , Neoplasias Cutáneas/congénitoRESUMEN
Epilepsy is a fascinating disorder reflective of ongoing brain activity which at times is disordered. There have been significant advances in the understanding of the pharmacology of antiepileptic drugs such that effective treatment is feasible. Understanding the epilepsies and the phenomena of epileptic seizures will permit one to successfully deal with the major issues around these syndromes and lead to a very rewarding outcome.