The prevalence of gout in an urban area of Izmir, Turkey: a population-based epidemiological study.

OBJECTIVES: This study aimed to determine the prevalence of gout in a general Turkish population, according to the American College of Rheumatology (Wallace) criteria proposed for gout classification. METHODS: This study was conducted in two districts of Izmir Province in Turkey, and involved 2835 subjects of ≥ 20 years of age. In the first stage, face-to-face interviews were performed at the subjects' registered households. In the second stage, subjects who gave positive answers in the screening questionnaire were invited to the hospital for a full examination, which included a detailed medical history, medication use and blood tests. RESULTS: A total of 2887 subjects were contacted, and complete interviews were obtained for 2835 (1551 women, 1284 men). A total of 312 subjects (227 women, 85 men) reported experiencing a short period of joint pain accompanied by swelling, redness or reduced range of movement, and 247 (79%) of these patients underwent a detailed clinical examination in the hospital. Gout was diagnosed in 11 patients (8 men, 3 women). We found minimum age- and sex-adjusted prevalence rates of gout of 0.31% (95% CI: 0.16-0.61) in subjects of ≥ 20 years of age, and 0.72% (95% CI: 0.37-1.24) in subjects of ≥ 40 years of age. CONCLUSIONS: Our data suggest that the estimated prevalence of gout (0.31%) is lower than the previously published estimated prevalence of rheumatoid arthritis (0.36%) in the same study population (14 definite rheumatoid arthritis cases among the 2835 subjects).

The investigation of radionuclide distributions in soil samples collected from Bursa, Turkey.

The distributions of (226)Ra, (232)Th, (40)K and (137)Cs activity concentrations were determined using a high-purity germanium detector in uncultivated surface soil samples collected from Bursa. The range of (226)Ra, (232)Th, (40)K and (137)Cs activity concentrations varied from 10±1 to 61±3 Bq kg(-1) (mean value 25±3 Bq kg(-1)), from 12±1 to 50±2 Bq kg(-1) (mean value 26±3 Bq kg(-1)), from 257±5 to 1010±11 Bq kg(-1) (mean value 435±44 Bq kg(-1)) and from 1.01±0.07 to 48.97±0.54 Bq kg(-1) (mean value 8.52±2.59 Bq kg(-1)), respectively. In addition, the mean outdoor absorbed dose rates in air, annual effective dose equivalent, radium equivalent activity and external hazard index were found to be 45 nGy h(-1), 56 µSv y(-1), 96 Bq kg(-1) and 0.26, respectively. The gross beta activity concentrations were determined using a Tennelec LB 1000-PW detector. The range of gross beta activity concentrations varied from 46±9 to 1199±113 Bq kg(-1) with a mean value of 541±19 Bq kg(-1).

Evaluation of radon concentration in well and tap waters in Bursa, Turkey.

(222)Rn measurements in water samples collected from 27 wells and 19 taps that were supplied from the investigated wells were conducted using the AlphaGUARD PQ 2000PRO radon gas analyser at sites across several geologic formations within the city of Bursa, Turkey. The measured radon concentrations ranged from 1.46 to 53.64 Bq l(-1) for well water and from 0.91 to 12.58 Bq l(-1) for tap water. Of the 27 sites sampled, only 7 had radon levels above the safe limit of 11.1 Bq l(-1) recommended by the USEPA. In general, all determined concentrations were well below the 100 Bq l(-1) revised reference level proposed by the European Union. These values of radon concentrations in water samples are compared with those reported from other countries. Doses resulting from the consumption of these waters were calculated. The minimum and the maximum annual mean effective doses due to (222)Rn intake through water consumption were 0.02 µSv a(-1) and 1.11 µSv a(-1), respectively.

A practical method for in-situ thickness determination using energy distribution of beta particles.

This paper discusses a method to determine the thickness of an absorber using the energy distribution of beta particles. An empirical relationship was obtained between the absorber thickness and the energy distribution of beta particles transmitted through. The thickness of a polyethylene radioactive source cover was determined by exploiting this relationship, which has largely been left unexploited allowing us to determine the in-situ cover thickness of beta sources in a fast, cheap and non-destructive way.

Calculation of angular distribution of 662 keV gamma rays by Monte Carlo method in copper medium.

This paper presents results on the angular distribution of Compton scattering of 662 keV gamma photons in both forward and backward hemispheres in copper medium. The number of scattered events graph has been determined for scattered gamma photons in both the forward and backward hemispheres and theoretical saturation thicknesses have been obtained using these results. Furthermore, response function of a 51 x 51 mm NaI(Tl) detector at 60 degrees angle with incoming photons scattered from a 10mm thick copper layer has been determined using Monte Carlo method.

Prevalence of primary Sjogren's syndrome in Turkey: a population-based epidemiological study.

OBJECTIVES: The aim of this study was to determine the prevalence of primary Sjogren's syndrome (pSS) in a general Turkish population according to the latest proposed American-European Consensus Group (AECG) criteria and European-1 (EU-1) criteria. METHODS: The study was conducted in two districts of Izmir and involved 2835 subjects 20 years of age and older. In the first stage, face-to-face interviews were performed at the registered households. In the second stage, subjects reporting symptoms of both dry eye and dry mouth were invited to the hospital for a full examination, which included Schirmer-1, sialometry and serologic tests. In the third stage, a minor salivary gland biopsy was performed as required. RESULTS: A total of 2887 subjects were contacted and a complete interview was obtained for 2835 (1551 female, 1284 male) subjects. A total of 159 subjects (126 female, 33 male) confirmed oral and ocular dryness, and 86 of these patients (54.1%) underwent a detailed clinical examination in the hospital. pSS was diagnosed in 10 patients (nine females) according to the EU-1 criteria, and in six patients (six females) according to the AECG criteria. We found a minimum crude prevalence of 0.21% [95% confidence interval (CI): 0.03-0.29] in the sample population and an age-sex adjusted prevalence of 0.16% (95% CI: 0.06-0.35), according to AECG criteria. According to EU-1 criteria, these prevalence rates were found to be 0.35% (95% CI: 0.10-0.45) and 0.28% (95% CI: 0.13-0.51) respectively. CONCLUSION: The pSS prevalence rates found in the Turkish population in this study were lower than the estimated prevalence rate in a general population.

Mass absorption and mass energy transfer coefficients for 0.4-10 MeV gamma rays in elemental solids and gases.

The mass energy absorption, the mass energy transfer and mass absorption coefficients have been widely used for problems and applications involving dose calculations. Direct measurements of the coefficients are difficult, and theoretical computations are usually employed. In this paper, analytical equations are presented for determining the mass energy transfer and mass absorption coefficients for gamma rays with an incident energy range between 0.4 and 10 MeV in nitrogen, silicon, carbon, copper and sodium iodide. The mass absorption and mass energy transfer coefficients for gamma rays were calculated, and the results obtained were compared with the values reported in the literature.

Calculation of total counting efficiency of a NaI(Tl) detector by hybrid Monte-Carlo method for point and disk sources.

This paper presents results on the total gamma counting efficiency of a NaI(Tl) detector from point and disk sources. The directions of photons emitted from the source were determined by Monte-Carlo techniques and the photon path lengths in the detector were determined by analytic equations depending on photon directions. This is called the hybrid Monte-Carlo method where analytical expressions are incorporated into the Monte-Carlo simulations. A major advantage of this technique is the short computation time compared to other techniques on similar computational platforms. Another advantage is the flexibility for inputting detector-related parameters (such as source-detector distance, detector radius, source radius, detector linear attenuation coefficient) into the algorithm developed, thus making it an easy and flexible method to apply to other detector systems and configurations. The results of the total counting efficiency model put forward for point and disc sources were compared with the previous work reported in the literature.

Frequency and severity of musculoskeletal symptoms in humans during an outbreak of trichinellosis caused by Trichinella britovi.

Musculoskeletal symptoms such as myalgia are well-known features in the course of trichinellosis; however, the characteristics of musculoskeletal findings have been described in detail in only 1 study. The present study was aimed to determine the joint and muscle symptoms in subjects diagnosed with acute trichinellosis at our rheumatology unit during a Trichinella britovi outbreak that occurred in Izmir, Turkey, in 2004. In total, 98 patients (55 females, 43 males; mean age 32.3 +/- 10.9 yr) were included in the study. A detailed history and full musculoskeletal examination were obtained in each patient. A self-administered questionnaire developed for recording the musculoskeletal symptoms was completed monthly until all the symptoms were resolved. Pain at the joints, restriction of movements (in shoulders, elbows, wrists, knees, ankles, and temporomandibular joints), myalgia, and muscle weakness (neck and shoulder girdle, muscles of the upper and forearm, back, thigh, and calf muscles) were assessed in every patient. Eosinophil counts, serum levels of creatine kinase, and lactate dehydrogenase also were analyzed. The most frequent musculoskeletal symptoms were muscle pain (86 cases [87.8%]), joint pain (83 [84.7%]), subjective muscle weakness (75 [76.5%]), and restriction of joint movements (63 [64.3%]). Calves, upper arm, neck and shoulder girdle, and forearms were the most affected muscle groups. Muscle pain was reported more frequently in the upper than in the lower extremities and during activity. The most frequent painful joints were shoulders, knees, wrists, and ankles. Upper extremity joints were affected more frequently than the lower extremity joints (77.6 vs. 70.4%). Joint pain occurred more frequently at rest. Both muscle weakness and restriction of joint movements were reported in and around the most frequently affected regions. No evidence of arthritis and objective muscle weakness was noted on physical examination in any patient. Musculoskeletal symptoms in the course of T. britovi infection are frequent but with an excellent prognosis. Joint pain in people suffering from acute trichinellosis may occur more frequently than reported previously.

The prevalence of rheumatoid arthritis in an urban population of Izmir-Turkey.

OBJECTIVE: To estimate the prevalence of rheumatoid arthritis (RA) in an urban area in Izmir, Turkey. METHODS: The study was conducted in the Balcova and Narlidere districts of Izmir and a total of 2,887 people aged 20 years or older were contacted with a 98.2% acceptance rate. Nine medical doctors administered an RA questionnaire by face-to-face interview. Subjects reporting a history of swelling in at least 2 joints lasting more than 4 continuous weeks or a history of a diagnosis of rheumatoid arthritis, inflammatory joint rheumatism or joint rheumatism were considered as screening positive and they were invited to come in for an examination. RA cases were defined by the 1987 American College of Rheumatology (ACR) criteria modifiedfor use in population studies. RESULTS: A total of 301 subjects (243 women, 58 men), or 10.6% of those who received the questionnaire were screening positive. 240 (79.7%) of these agreed to undergo a clinical examination either in the clinic or at home. Among these, 14 (12 female, 2 male) patients fulfilled the ACR criteria for RA. The prevalence of RA was 0.49% (95% CI 0.27-0.83) in the total population interviewed, 0.77% (95% CI 0.40-1.35) in women and 0.15% (95%CI 0.02-0.60) in men. The age- and sex-adjusted prevalence for the general population was estimated as 0.36%. Five of the 14 RA (36%) cases had not been diagnosed previously CONCLUSION: These data are consistent with the results of other Mediterranean countries. A significant proportion of RA cases remain undiagnosed in the community.