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1.
Clin Exp Dermatol ; 47(2): 386-388, 2022 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-34346107

RESUMEN

Under-representation of ethnic minorities in clinical research has major implications for equality of access to current treatments in the field of dermatology. To determine whether there has been equitable representation of black individuals in the clinical trials for dermatological new molecular entities (NMEs) approved by the US Food and Drug Administration (FDA) since 2015, we analysed data from the FDA Drug Trials Snapshots programme from January 2015 to the present. During this period, there was significant under-representation of black participants in clinical trials for NMEs treating acne vulgaris, plaque psoriasis, actinic keratosis and squamous cell carcinoma. These findings highlight the need to prioritize representation of ethnic minorities in clinical trials to enhance clinical practice in the field of dermatology and to improve the care and health of minorities.


Asunto(s)
Negro o Afroamericano/estadística & datos numéricos , Ensayos Clínicos como Asunto , Fármacos Dermatológicos , Aprobación de Drogas/estadística & datos numéricos , Selección de Paciente , Dermatología , Minorías Étnicas y Raciales/estadística & datos numéricos , Humanos , Enfermedades de la Piel/tratamiento farmacológico , Enfermedades de la Piel/etnología , Estados Unidos , United States Food and Drug Administration
2.
J Clin Pharm Ther ; 43(6): 910-913, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29956355

RESUMEN

WHAT IS KNOWN AND OBJECTIVE: Candida catenulata is a fungus commonly found in Australian cheeses. C. catenulata has been identified as the causative pathogen for one report of onychomycosis and one report of candidaemia. CASE DESCRIPTION: A 37-year-old male underwent surgery for an incarcerated umbilical hernia repair and bowel obstruction and presented with severe abdominal pain and ascitic fluid draining from the surgical site. C. catenulata was isolated in blood cultures. The patient was treated with antifungal therapy for approximately 6 weeks. WHAT IS NEW AND CONCLUSION: To our knowledge, this is the first case describing successful treatment of possible fungal endocarditis caused by C. catenulata.


Asunto(s)
Antifúngicos/administración & dosificación , Candidemia/tratamiento farmacológico , Endocarditis/tratamiento farmacológico , Fluconazol/administración & dosificación , Dolor Abdominal/etiología , Administración Oral , Adulto , Candida/aislamiento & purificación , Candidemia/diagnóstico , Candidemia/microbiología , Endocarditis/diagnóstico , Endocarditis/microbiología , Fluconazol/uso terapéutico , Hernia Umbilical/cirugía , Humanos , Obstrucción Intestinal/cirugía , Cirrosis Hepática/patología , Masculino , Resultado del Tratamiento
3.
J Gastroenterol Hepatol ; 12(6): S45-7, 1997 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-9195411

RESUMEN

There are some differences between the spectrum of gastroenterological diseases in Vietnam compared with those of more developed countries. These may be due to different living standards, quality of nutrition, and different infection rates of intestinal parasites and hepatotropic viruses. Gastric carcinoma and hepatocellular carcinoma (HCC) are leading malignancies, while colorectal cancer is less frequent. Bile duct stones often have Ascaris eggs in the centre, and they prevail in incidence over gall-bladder stones. The majority of digestive cancers are detected at a very late stage. The Vietnamese Association of Gastroenterology aims to contribute to the development of modern gastroenterology (GE) in Vietnam, to study and apply recent advances in imaging technology, such as fibre-optic diagnostic and therapeutical endoscopy, ultrasonography, laparoscopic surgery etc. and to do further work in molecular biology. For this purpose, besides our self-reliance, we need, and ask for, support and assistance from the Japanese Society of GE (JSGE), the Asian Pacific Association of GE (APAGE) and the Organisation Mondiale de GE (OMEGE). At the same time, we suggest a choice be made among the different technologies, bearing in mind their cost-effectiveness, and to give preference to measures for the primary prevention and early detection of the diseases. Japanese experience in the early detection of gastric cancer and HCC, and in the Percutaneous Ethanol Injection Therapy (PEIT) for treatment of HCC, are highly appreciated. We recommend also a judicious and scientific combination of traditional medicine and modern technology in the research and the struggle against digestive diseases.


Asunto(s)
Gastroenterología/tendencias , Países en Desarrollo , Enfermedades Gastrointestinales/epidemiología , Humanos , Ciencia del Laboratorio Clínico , Práctica Profesional , Sociedades Médicas , Vietnam/epidemiología
4.
J Gastroenterol Hepatol ; 12(5): S15-8, 1997 May.
Artículo en Inglés | MEDLINE | ID: mdl-9195396

RESUMEN

The most frequent hepatobiliary diseases in Vietnam are chronic hepatitis and cirrhosis, liver abscess, hepatobiliary ascaridiasis, angiocholitis, biliary lithiasis and primary liver cancer. The principal causes of chronic hepatitis and cirrhosis are HBV and HCV infections. Alcohol and chemicals (drugs, agricultural, industrial, war herbicides) also play an important role. Malaria causes hepatitis and fibrosis lesions, however no cirrhotic lesions were observed. There are two categories of liver abscess, amoebic and cholangitic, often caused by ascaridiasis. Treatment of amoebic abscesses is, at first, non-surgical for small abscesses, often combined with ultrasound guided abscess puncture. Cholangitis abscesses are more serious and often require surgical intervention. Among the gallstones, only 15% are of the gall-bladder, the majority are choledocho- and intrahepatic-lithiasis, composed largely of calcium bilirubinate and are frequently caused by Ascaris-related cholangitis and the nucleation of Ascaris eggs. Forty-seven per cent of acute cholecystitis are acalculous, showing a higher frequency than in Western countries. Primary liver cancer is one of the most frequent malignancies in Vietnam. More than 90% of liver cancers are hepatocellular carcinomas. The principal causes are HBV infection, followed by HCV infection, aflatoxin, alcohol and chemicals. Recent efforts aiming at earlier diagnosis, by selective screening in high-risk groups, have used clinical surveillance, abdominal sonography and AFP level determination. Promising results were obtained in prevention trials by reducing the high AFP level of cirrhotic patients using a vegetal drug, Gacavit, and by treatment with percutaneous ethanol injection therapy, as an alternative therapeutic measure for liver tumour resection.


Asunto(s)
Enfermedades de las Vías Biliares/etiología , Hepatopatías/etiología , Enfermedades de las Vías Biliares/epidemiología , Enfermedades de las Vías Biliares/terapia , Humanos , Hepatopatías/epidemiología , Hepatopatías/terapia , Morbilidad , Vietnam/epidemiología
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