RESUMEN
20 patients of schistosomal hepatic fibrosis and splenomegaly (SHF) with and without haematemesis were examined. Typing for HLA-A, B and C antigens in these patients were compared with those of a group of 100 Egyptian controls. The study showed the presence of an association between HLA-A1 and B5 antigens in SHF cases. However, there was no significant association between HLA antigens and SHF cases with haematemesis.
Asunto(s)
Antígenos HLA , Antígenos HLA-B , Hematemesis/etiología , Esquistosomiasis mansoni/inmunología , Adolescente , Adulto , Antígeno HLA-A1 , Hematemesis/inmunología , Hepatomegalia/etiología , Hepatomegalia/inmunología , Humanos , Persona de Mediana Edad , Esquistosomiasis mansoni/complicaciones , Esplenomegalia/etiología , Esplenomegalia/inmunologíaRESUMEN
Thirty-two female mice infected with Schistosoma mansoni and 16 non-infected control mice were studied. They were killed by cervical dislocation, dissected and their ovaries examined histopathologically and histochemically. Ovaries of infected mice showed definite structural damage. No ova, worms or specific granulomata were detected. The study points to a possible immunological mechanism producing such changes simulating those occurring in schistosomal nephropathy. Detection of immune complexes in such organs is recommended.