1.
Mamm Genome
; 8(4): 284, 1997 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9096113
2.
Mamm Genome
; 7(10): 767-9, 1996 Oct.
Artículo
en Inglés
| MEDLINE
| ID: mdl-8854865
3.
Mol Gen Genet
; 248(2): 229-35, 1995 Jul 28.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7651346
RESUMEN
The activity of the yeast activator HAP1 in vivo requires heme. A heme responsive domain of HAP1 was identified previously. It is adjacent to the DNA-binding domain and appears to block DNA binding in the absence of heme. Here we describe a novel genetic selection which yielded mutants of HAP1 that are independent of heme when assayed for activation. These mutants define a second region of HAP1, close to the activation domain, which also controls its response to heme.