Deep-Learning Reconstruction of High-Resolution CT Improves Interobserver Agreement for the Evaluation of Pulmonary Fibrosis.

Objective: This study aimed to investigate whether deep-learning reconstruction (DLR) improves interobserver agreement in the evaluation of honeycombing for patients with interstitial lung disease (ILD) who underwent high-resolution computed tomography (CT) compared with hybrid iterative reconstruction (HIR). Methods: In this retrospective study, 35 consecutive patients suspected of ILD who underwent CT including the chest region were included. High-resolution CT images of the unilateral lung with DLR and HIR were reconstructed for the right and left lungs. A radiologist placed regions of interest on the lung and measured standard deviation of CT attenuation (i.e., quantitative image noise). In the qualitative image analyses, 5 blinded readers assessed the presence of honeycombing and reticulation, qualitative image noise, artifacts, and overall image quality using a 5-point scale (except for artifacts which was evaluated using a 3-point scale). Results: The quantitative and qualitative image noise in DLR was remarkably reduced compared to that in HIR (P < .001). Artifacts and overall DLR quality were significantly improved compared to those of HIR (P < .001 for 4 out of 5 readers). Interobserver agreement in the evaluations of honeycombing and reticulation for DLR (0.557 [0.450-0.693] and 0.525 [0.470-0.541], respectively) were higher than those for HIR (0.321 [0.211-0.520] and 0.470 [0.354-0.533], respectively). A statistically significant difference was found for honeycombing (P = .014). Conclusions: DLR improved interobserver agreement in the evaluation of honeycombing in patients with ILD on CT compared to HIR.

Deep Learning Reconstruction Plus Single-Energy Metal Artifact Reduction for Supra Hyoid Neck CT in Patients With Dental Metals.

Purpose: We investigated the effect of deep learning reconstruction (DLR) plus single-energy metal artifact reduction (SEMAR) on neck CT in patients with dental metals, comparing it with DLR and with hybrid iterative reconstruction (Hybrid IR)-SEMAR. Methods: In this retrospective study, 32 patients (25 men, 7 women; mean age: 63 ± 15 years) with dental metals underwent contrast-enhanced CT of the oral and oropharyngeal regions. Axial images were reconstructed using DLR, Hybrid IR-SEMAR, and DLR-SEMAR. In quantitative analyses, degrees of image noise and artifacts were evaluated. In one-by-one qualitative analyses, 2 radiologists evaluated metal artifacts, the depiction of structures, and noise on five-point scales. In side-by-side qualitative analyses, artifacts and overall image quality were evaluated by comparing Hybrid IR-SEMAR with DLR-SEMAR. Results: Artifacts were significantly less with DLR-SEMAR than with DLR in quantitative (P < .001) and one-by-one qualitative (P < .001) analyses, which resulted in significantly better depiction of most structures (P < .004). Artifacts in side-by-side analysis and image noise in quantitative and one-by-one qualitative analyses (P < .001) were significantly less with DLR-SEMAR than with Hybrid IR-SEMAR, resulting in significantly better overall quality of DLR-SEMAR. Conclusions: Compared with DLR and Hybrid IR-SEMAR, DLR-SEMAR provided significantly better supra hyoid neck CT images in patients with dental metals.

Effect of Deep Learning Reconstruction on Evaluating Cervical Spinal Canal Stenosis With Computed Tomography.

OBJECTIVE: Magnetic resonance imaging (MRI) is commonly used to evaluate cervical spinal canal stenosis; however, some patients are ineligible for MRI. We aimed to assess the effect of deep learning reconstruction (DLR) in evaluating cervical spinal canal stenosis using computed tomography (CT) compared with hybrid iterative reconstruction (hybrid IR). METHODS: This retrospective study included 33 patients (16 male patients; mean age, 57.7 ± 18.4 years) who underwent cervical spine CT. Images were reconstructed using DLR and hybrid IR. In the quantitative analyses, noise was recorded by placing the regions of interest on the trapezius muscle. In the qualitative analyses, 2 radiologists evaluated the depiction of structures, image noise, overall image quality, and degree of cervical canal stenosis. We additionally evaluated the agreement between MRI and CT in 15 patients for whom preoperative cervical MRI was available. RESULTS: Image noise was less with DLR than hybrid IR in the quantitative ( P ≤ 0.0395) and subjective analyses ( P ≤ 0.0023), and the depiction of most structures was improved ( P ≤ 0.0052), which resulted in better overall quality ( P ≤ 0.0118). Interobserver agreement in the assessment of spinal canal stenosis with DLR (0.7390; 95% confidence interval [CI], 0.7189-0.7592) was superior to that with hybrid IR (0.7038; 96% CI, 0.6846-0.7229). As for the agreement between MRI and CT, significant improvement was observed for 1 reader with DLR (0.7910; 96% CI, 0.7762-0.8057) than hybrid IR (0.7536; 96% CI, 0.7383-0.7688). CONCLUSIONS: Deep learning reconstruction provided better quality cervical spine CT images in the evaluation of cervical spinal stenosis than hybrid IR.

Deep-learning reconstruction for the evaluation of lumbar spinal stenosis in computed tomography.

To compare the quality and interobserver agreement in the evaluation of lumbar spinal stenosis (LSS) on computed tomography (CT) images between deep-learning reconstruction (DLR) and hybrid iterative reconstruction (hybrid IR). This retrospective study included 30 patients (age, 71.5 ± 12.5 years; 20 men) who underwent unenhanced lumbar CT. Axial and sagittal CT images were reconstructed using hybrid IR and DLR. In the quantitative analysis, a radiologist placed regions of interest within the aorta and recorded the standard deviation of the CT attenuation (i.e., quantitative image noise). In the qualitative analysis, 2 other blinded radiologists evaluated the subjective image noise, depictions of structures, overall image quality, and degree of LSS. The quantitative image noise in DLR (14.8 ± 1.9/14.2 ± 1.8 in axial/sagittal images) was significantly lower than that in hybrid IR (21.4 ± 4.4/20.6 ± 4.0) (P < .0001 for both, paired t test). Subjective image noise, depictions of structures, and overall image quality were significantly better with DLR than with hybrid IR (P < .006, Wilcoxon signed-rank test). Interobserver agreements in the evaluation of LSS (with 95% confidence interval) were 0.732 (0.712-0.751) and 0.794 (0.781-0.807) for hybrid IR and DLR, respectively. DLR provided images with improved quality and higher interobserver agreement in the evaluation of LSS in lumbar CT than hybrid IR.

Deep learning reconstruction with single-energy metal artifact reduction in pelvic computed tomography for patients with metal hip prostheses.

PURPOSE: The aim of this study was to assess the impact of the deep learning reconstruction (DLR) with single-energy metal artifact reduction (SEMAR) (DLR-S) technique in pelvic helical computed tomography (CT) images for patients with metal hip prostheses and compare it with DLR and hybrid iterative reconstruction (IR) with SEMAR (IR-S). MATERIALS AND METHODS: This retrospective study included 26 patients (mean age 68.6 ± 16.6 years, with 9 males and 17 females) with metal hip prostheses who underwent a CT examination including the pelvis. Axial pelvic CT images were reconstructed using DLR-S, DLR, and IR-S. In one-by-one qualitative analyses, two radiologists evaluated the degree of metal artifacts, noise, and pelvic structure depiction. In side-by-side qualitative analyses (DLR-S vs. IR-S), the two radiologists evaluated metal artifacts and overall quality. By placing regions of interest on the bladder and psoas muscle, the standard deviations of their CT attenuation were recorded, and the artifact index was calculated based on them. Results were compared between DLR-S vs. DLR and DLR vs. IR-S using the Wilcoxon signed-rank test. RESULTS: In one-by-one qualitative analyses, metal artifacts and structure depiction in DLR-S were significantly better than those in DLR; however, between DLR-S and IR-S, significant differences were noted only for reader 1. Image noise in DLR-S was rated as significantly reduced compared with that in IR-S by both readers. In side-by-side analyses, both readers rated that the DLR-S images are significantly better than IR-S images regarding overall image quality and metal artifacts. The median (interquartile range) of the artifact index for DLR-S was 10.1 (4.4-16.0) and was significantly better than those for DLR (23.1, 6.5-36.1) and IR-S (11.4, 7.8-17.9). CONCLUSION: DLR-S provided better pelvic CT images in patients with metal hip prostheses than IR-S and DLR.

Comparison of Deep-Learning Image Reconstruction With Hybrid Iterative Reconstruction for Evaluating Lung Nodules With High-Resolution Computed Tomography.

OBJECTIVE: This study aimed to investigate the impact of deep-learning reconstruction (DLR) on the detailed evaluation of solitary lung nodule using high-resolution computed tomography (HRCT) compared with hybrid iterative reconstruction (hybrid IR). METHODS: This retrospective study was approved by our institutional review board and included 68 consecutive patients (mean ± SD age, 70.1 ± 12.0 years; 37 men and 31 women) who underwent computed tomography between November 2021 and February 2022. High-resolution computed tomography images with a targeted field of view of the unilateral lung were reconstructed using filtered back projection, hybrid IR, and DLR, which is commercially available. Objective image noise was measured by placing the regions of interest on the skeletal muscle and recording the SD of the computed tomography attenuation. Subjective image analyses were performed by 2 blinded radiologists taking into consideration the subjective noise, artifacts, depictions of small structures and nodule rims, and the overall image quality. In subjective analyses, filtered back projection images were used as controls. Data were compared between DLR and hybrid IR using the paired t test and Wilcoxon signed-rank sum test. RESULTS: Objective image noise in DLR (32.7 ± 4.2) was significantly reduced compared with hybrid IR (35.3 ± 4.4) ( P < 0.0001). According to both readers, significant improvements in subjective image noise, artifacts, depictions of small structures and nodule rims, and overall image quality were observed in images derived from DLR compared with those from hybrid IR ( P < 0.0001 for all). CONCLUSIONS: Deep-learning reconstruction provides a better high-resolution computed tomography image with improved quality compared with hybrid IR.

A Case of Frequently Relapsing Minimal-Change Nephrotic Syndrome with Steroid-Induced Psychiatric Syndrome Treated by Low-Dose, Short-Term Steroid Therapy in Combination with Cyclosporine.

Adults with minimal-change nephrotic syndrome (MCNS) generally receive oral prednisolone (PSL) at an initial dosage of 1.0 mg/kg/day for a minimum of 4 weeks, with 80% of patients achieving clinical remission. However, relapses are frequent, necessitating repeated treatment with high-dose PSL. Long-term treatment with high-dose steroids increases the risk of steroid toxicities, such as diabetes mellitus, gastric complications, infections, osteoporosis, and steroid-induced psychiatric syndrome (SIPS), which may compromise the patient's quality of life. Strategies are therefore needed to reduce the dosage and duration of steroid therapy for frequently relapsing MCNS (FRNS). Here, we suggest a new combination therapy of low-dose and short-term steroid with cyclosporine (CsA). We encountered an adult patient who developed recurrence of FRNS with depression arising from SIPS and was treated using low-dose, short-term PSL combined with CsA. He was successfully treated with PSL at an initial dosage of 0.3 mg/kg/day (20 mg/day) for just 2 weeks combined with CsA, allowing earlier induction of complete remission. We then promptly reduced the dose of PSL to below a physiological dosage (5 mg/day) over 3 weeks without relapse after episodes of SIPS and quickly resolved psychiatric symptoms. CsA in combination with PSL can reduce the initial dosage of PSL, shorten the time to remission, and easily maintain clinical remission. This protocol appears clinically useful and potentially applicable as a future treatment strategy for FRNS troubled by SIPS.